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Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

Fujita K, Horikawa I, Mondal AM, Jenkins LM, Appella E, Vojtesek B, Bourdon JC, Lane DP, Harris CC.

Nat Cell Biol. 2010 Dec;12(12):1205-12. doi: 10.1038/ncb2123. Epub 2010 Nov 7.


p53 governs telomere regulation feedback too, via TRF2.

Horikawa I, Fujita K, Harris CC.

Aging (Albany NY). 2011 Jan;3(1):26-32.


A switch-like dynamic mechanism for the initiation of replicative senescence.

Zhang QH, Tian XJ, Liu F, Wang W.

FEBS Lett. 2014 Nov 28;588(23):4369-74. doi: 10.1016/j.febslet.2014.09.043. Epub 2014 Oct 12.


Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

Denchi EL, de Lange T.

Nature. 2007 Aug 30;448(7157):1068-71. Epub 2007 Aug 8.


Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA.

Stagno D'Alcontres M, Mendez-Bermudez A, Foxon JL, Royle NJ, Salomoni P.

J Cell Biol. 2007 Dec 3;179(5):855-67.


A two-step mechanism for TRF2-mediated chromosome-end protection.

Okamoto K, Bartocci C, Ouzounov I, Diedrich JK, Yates JR 3rd, Denchi EL.

Nature. 2013 Feb 28;494(7438):502-5. doi: 10.1038/nature11873. Epub 2013 Feb 6.


Essential role for the TRF2 telomere protein in adult skin homeostasis.

Martínez P, Ferrara-Romeo I, Flores JM, Blasco MA.

Aging Cell. 2014 Aug;13(4):656-68. doi: 10.1111/acel.12221. Epub 2014 Apr 14.


DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.

Celli GB, de Lange T.

Nat Cell Biol. 2005 Jul;7(7):712-8. Epub 2005 Jun 19.


DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres.

Khadka P, Lee JH, Baek SH, Oh SY, Chung IK.

Biochem J. 2014 Oct 1;463(1):19-30. doi: 10.1042/BJ20131395.


TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.

Ye J, Lenain C, Bauwens S, Rizzo A, Saint-Léger A, Poulet A, Benarroch D, Magdinier F, Morere J, Amiard S, Verhoeyen E, Britton S, Calsou P, Salles B, Bizard A, Nadal M, Salvati E, Sabatier L, Wu Y, Biroccio A, Londoño-Vallejo A, Giraud-Panis MJ, Gilson E.

Cell. 2010 Jul 23;142(2):230-42. doi: 10.1016/j.cell.2010.05.032.


Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response.

Jullien L, Mestre M, Roux P, Gire V.

Nucleic Acids Res. 2013 Jan;41(2):900-11. doi: 10.1093/nar/gks1121. Epub 2012 Nov 27.


Different telomere damage signaling pathways in human and mouse cells.

Smogorzewska A, de Lange T.

EMBO J. 2002 Aug 15;21(16):4338-48.


TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.

Zhang P, Furukawa K, Opresko PL, Xu X, Bohr VA, Mattson MP.

J Neurochem. 2006 Apr;97(2):567-81. Epub 2006 Mar 15.


The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.

Buscemi G, Zannini L, Fontanella E, Lecis D, Lisanti S, Delia D.

Curr Biol. 2009 May 26;19(10):874-9. doi: 10.1016/j.cub.2009.03.064. Epub 2009 Apr 16.


MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.

Caslini C, Connelly JA, Serna A, Broccoli D, Hess JL.

Mol Cell Biol. 2009 Aug;29(16):4519-26. doi: 10.1128/MCB.00195-09. Epub 2009 Jun 15.


Differential senescence capacities in meibomian gland carcinoma and basal cell carcinoma.

Zhang L, Huang X, Zhu X, Ge S, Gilson E, Jia R, Ye J, Fan X.

Int J Cancer. 2016 Mar 15;138(6):1442-52. doi: 10.1002/ijc.29882. Epub 2015 Oct 23.


Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.

van Overbeek M, de Lange T.

Curr Biol. 2006 Jul 11;16(13):1295-302. Epub 2006 May 25.


Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.

Luo Z, Feng X, Wang H, Xu W, Zhao Y, Ma W, Jiang S, Liu D, Huang J, Songyang Z.

Aging Cell. 2015 Jun;14(3):391-9. doi: 10.1111/acel.12304. Epub 2015 Mar 6.


p300-mediated acetylation of TRF2 is required for maintaining functional telomeres.

Her YR, Chung IK.

Nucleic Acids Res. 2013 Feb 1;41(4):2267-83. doi: 10.1093/nar/gks1354. Epub 2013 Jan 9.


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