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Select item 210558481.

Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.

Marrazzo A, Fiorito J, Zappalà L, Prezzavento O, Ronsisvalle S, Pasquinucci L, Scoto GM, Bernardini R, Ronsisvalle G.

Eur J Med Chem. 2011 Jan;46(1):433-8. doi: 10.1016/j.ejmech.2010.10.012. Epub 2010 Oct 15.

PMID:: 21055848

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Select item 169512392.

Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer.

Kulp SK, Chen CS, Wang DS, Chen CY, Chen CS.

Clin Cancer Res. 2006 Sep 1;12(17):5199-206.

PMID:: 16951239

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Select item 260689143.

MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells.

Di Giacomo V, Di Valerio V, Rapino M, Bosco D, Cacciatore I, Ciulla M, Marrazzo A, Fiorito J, Di Stefano A, Cataldi A.

Cell Mol Biol (Noisy-le-grand). 2015 Jun 8;61(3):17-23.

PMID:: 26068914

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Select item 174198034.

Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells.

Cobos EJ, del Pozo E, Baeyens JM.

J Neurochem. 2007 Aug;102(3):812-25. Epub 2007 Apr 10.

PMID:: 17419803

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Select item 288693985.

Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents.

Dichiara M, Amata E, Rescifina A, Prezzavento O, Floresta G, Parenti C, Pittalà V, Marrazzo A.

Future Med Chem. 2017 Oct;9(15):1749-1764. doi: 10.4155/fmc-2017-0064. Epub 2017 Sep 4. Review.

PMID:: 28869398

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Select item 254613066.

Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.

Sozio P, Fiorito J, Di Giacomo V, Di Stefano A, Marinelli L, Cacciatore I, Cataldi A, Pacella S, Turkez H, Parenti C, Rescifina A, Marrazzo A.

Eur J Med Chem. 2015 Jan 27;90:1-9. doi: 10.1016/j.ejmech.2014.11.012. Epub 2014 Nov 6.

PMID:: 25461306

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Select item 79028707.

Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.

Jaen JC, Caprathe BW, Pugsley TA, Wise LD, Akunne H.

J Med Chem. 1993 Nov 26;36(24):3929-36.

PMID:: 7902870

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Select item 76719998.

Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture.

Brent PJ, Pang GT.

Eur J Pharmacol. 1995 May 15;278(2):151-60.

PMID:: 7671999

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Select item 205688949.

Binding of AR to SMRT/N-CoR complex and its co-operation with PSA promoter in prostate cancer cells treated with natural histone deacetylase inhibitor NaB.

Trtkova K, Paskova L, Matijescukova N, Strnad M, Kolar Z.

Neoplasma. 2010;57(5):406-14.

PMID:: 20568894

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Select item 781297310.

Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.

Vilner BJ, John CS, Bowen WD.

Cancer Res. 1995 Jan 15;55(2):408-13.

PMID:: 7812973

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Select item 1899705711.

Cytotoxicity of sigma-receptor ligands is associated with major changes of cellular metabolism and complete occupancy of the sigma-2 subpopulation.

Rybczynska AA, Dierckx RA, Ishiwata K, Elsinga PH, van Waarde A.

J Nucl Med. 2008 Dec;49(12):2049-56. doi: 10.2967/jnumed.108.053876. Epub 2008 Nov 7.

PMID:: 18997057

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Select item 1049351112.

Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors.

John CS, Vilner BJ, Geyer BC, Moody T, Bowen WD.

Cancer Res. 1999 Sep 15;59(18):4578-83.

PMID:: 10493511

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Select item 1465493713.

Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells.

Thelen P, Schweyer S, Hemmerlein B, Wuttke W, Seseke F, Ringert RH.

Int J Oncol. 2004 Jan;24(1):25-31.

PMID:: 14654937

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Select item 1056296614.

[Functional characterization of a sigma receptor and its gene expression by haloperidol].

Nakata Y, Inoue A, Sugita S.

Nihon Yakurigaku Zasshi. 1999 Jul;114(1):61-8. Review. Japanese.

PMID:: 10562966

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Select item 813007815.

Signalling via rat dopamine D2-receptors expressed in mouse fibroblasts is not influenced by compounds binding to the sigma sites of these cells.

Sommermeyer H, Dompert WU, Glaser T.

Cell Signal. 1993 Nov;5(6):747-52. Erratum in: Cell Signal 1994 Feb;6(2):245.

PMID:: 8130078

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Select item 1538978716.

Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells.

Frønsdal K, Saatcioglu F.

Prostate. 2005 Feb 15;62(3):299-306.

PMID:: 15389787

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Select item 1932610117.

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Entrena JM, Cobos EJ, Nieto FR, Cendán CM, Baeyens JM, Del Pozo E.

Psychopharmacology (Berl). 2009 Jul;205(1):21-33. doi: 10.1007/s00213-009-1513-8. Epub 2009 Mar 27.

PMID:: 19326101

Free PMC Article

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Select item 1276740018.

Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands.

Ishiwata K, Kawamura K, Kobayashi T, Matsuno K.

Nucl Med Biol. 2003 May;30(4):429-34.

PMID:: 12767400

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Select item 2106965719.

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity.

Abate C, Niso M, Contino M, Colabufo NA, Ferorelli S, Perrone R, Berardi F.

ChemMedChem. 2011 Jan 3;6(1):73-80. doi: 10.1002/cmdc.201000371.

PMID:: 21069657

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Select item 1525645820.

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.

Spruce BA, Campbell LA, McTavish N, Cooper MA, Appleyard MV, O'Neill M, Howie J, Samson J, Watt S, Murray K, McLean D, Leslie NR, Safrany ST, Ferguson MJ, Peters JA, Prescott AR, Box G, Hayes A, Nutley B, Raynaud F, Downes CP, Lambert JJ, Thompson AM, Eccles S.

Cancer Res. 2004 Jul 15;64(14):4875-86.

PMID:: 15256458

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