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Items: 1 to 20 of 202

1.

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.

Su H, Li J, Menon S, Liu J, Kumarapeli AR, Wei N, Wang X.

Circ Res. 2011 Jan 7;108(1):40-50. doi: 10.1161/CIRCRESAHA.110.230607. Epub 2010 Nov 4.

2.

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.

Su H, Li J, Osinska H, Li F, Robbins J, Liu J, Wei N, Wang X.

Circ Heart Fail. 2013 Sep 1;6(5):1049-57. doi: 10.1161/CIRCHEARTFAILURE.113.000338. Epub 2013 Jul 19.

3.

COP9 signalosome regulates autophagosome maturation.

Su H, Li F, Ranek MJ, Wei N, Wang X.

Circulation. 2011 Nov 8;124(19):2117-28. doi: 10.1161/CIRCULATIONAHA.111.048934. Epub 2011 Oct 10.

4.

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.

Su H, Li J, Zhang H, Ma W, Wei N, Liu J, Wang X.

Circ Res. 2015 Nov 6;117(11):956-66. doi: 10.1161/CIRCRESAHA.115.306783. Epub 2015 Sep 17.

5.

Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.

Lei D, Li F, Su H, Liu J, Wei N, Wang X.

PLoS One. 2013 Jul 1;8(7):e67793. doi: 10.1371/journal.pone.0067793. Print 2013.

6.

The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis.

Hetfeld BK, Peth A, Sun XM, Henklein P, Cohen GM, Dubiel W.

Apoptosis. 2008 Feb;13(2):187-95.

PMID:
18060501
7.

Roles of COP9 signalosome in cancer.

Lee MH, Zhao R, Phan L, Yeung SC.

Cell Cycle. 2011 Sep 15;10(18):3057-66. Epub 2011 Sep 15. Review.

8.

The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart.

Liu J, Su H, Wang X.

Autophagy. 2016;12(3):601-2. doi: 10.1080/15548627.2015.1136773.

9.

The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.

Su H, Huang W, Wang X.

Int J Biochem Cell Biol. 2009 Mar;41(3):615-24. doi: 10.1016/j.biocel.2008.07.008. Epub 2008 Jul 25.

10.

The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.

Huang X, Langelotz C, Hetfeld-Pechoc BK, Schwenk W, Dubiel W.

J Mol Biol. 2009 Aug 28;391(4):691-702. doi: 10.1016/j.jmb.2009.06.066. Epub 2009 Jul 1.

PMID:
19576224
11.

Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes.

Rockel B, Schmaler T, Huang X, Dubiel W.

Biochem Biophys Res Commun. 2014 Jul 25;450(2):991-7. doi: 10.1016/j.bbrc.2014.06.093. Epub 2014 Jun 25.

PMID:
24973710
12.

Control of Deneddylation by the COP9 Signalosome.

Schmaler T, Dubiel W.

Subcell Biochem. 2010;54:57-68. doi: 10.1007/978-1-4419-6676-6_5.

PMID:
21222273
13.

The COP9 signalosome: an alternative lid for the 26S proteasome?

Li L, Deng XW.

Trends Cell Biol. 2003 Oct;13(10):507-9. Review.

PMID:
14507477
14.

Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers.

Gummlich L, Rabien A, Jung K, Dubiel W.

Int J Biochem Cell Biol. 2013 Jul;45(7):1327-37. doi: 10.1016/j.biocel.2013.03.023. Epub 2013 Apr 10. Review.

PMID:
23583660
15.

The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs.

Neuss H, Huang X, Hetfeld BK, Deva R, Henklein P, Nigam S, Mall JW, Schwenk W, Dubiel W.

J Mol Med (Berl). 2007 Sep;85(9):961-70. Epub 2007 Apr 11.

PMID:
17429597
16.

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload.

Ranek MJ, Zheng H, Huang W, Kumarapeli AR, Li J, Liu J, Wang X.

J Mol Cell Cardiol. 2015 Aug;85:273-81. doi: 10.1016/j.yjmcc.2015.06.014. Epub 2015 Jun 25.

17.

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.

Lei D, Li F, Su H, Tian Z, Ye B, Wei N, Wang X.

Cell Death Differ. 2011 Feb;18(2):259-70. doi: 10.1038/cdd.2010.98. Epub 2010 Aug 6.

18.

DELLA proteins restrain germination and elongation growth in Arabidopsis thaliana COP9 signalosome mutants.

Dohmann EM, Nill C, Schwechheimer C.

Eur J Cell Biol. 2010 Feb-Mar;89(2-3):163-8. doi: 10.1016/j.ejcb.2009.12.001. Epub 2010 Jan 18.

PMID:
20083325
19.

Protection of cullin-RING E3 ligases by CSN-UBP12.

Wu JT, Chan YR, Chien CT.

Trends Cell Biol. 2006 Jul;16(7):362-9. Epub 2006 Jun 9. Review.

PMID:
16762551
20.

X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling.

He F, Lu D, Jiang B, Wang Y, Liu Q, Liu Q, Shao C, Li X, Gong Y.

Biochim Biophys Acta. 2013 May;1832(5):595-605. doi: 10.1016/j.bbadis.2013.01.015. Epub 2013 Jan 26.

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