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Items: 1 to 20 of 101


Voltage profile along the permeation pathway of an open channel.

Contreras JE, Chen J, Lau AY, Jogini V, Roux B, Holmgren M.

Biophys J. 2010 Nov 3;99(9):2863-9. doi: 10.1016/j.bpj.2010.08.053.


A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.

Napolitano LM, Bisha I, De March M, Marchesi A, Arcangeletti M, Demitri N, Mazzolini M, Rodriguez A, Magistrato A, Onesti S, Laio A, Torre V.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3619-28. doi: 10.1073/pnas.1503334112. Epub 2015 Jun 22.


Gating at the selectivity filter in cyclic nucleotide-gated channels.

Contreras JE, Srikumar D, Holmgren M.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3310-4. doi: 10.1073/pnas.0709809105. Epub 2008 Feb 20.


Mutations reveal voltage gating of CNGA1 channels in saturating cGMP.

Martínez-François JR, Xu Y, Lu Z.

J Gen Physiol. 2009 Aug;134(2):151-64. doi: 10.1085/jgp.200910240.


Structural basis of ion permeation gating in Slo2.1 K+ channels.

Garg P, Gardner A, Garg V, Sanguinetti MC.

J Gen Physiol. 2013 Nov;142(5):523-42. doi: 10.1085/jgp.201311064.


A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions.

Marchesi A, Mazzolini M, Torre V.

J Physiol. 2012 Oct 15;590(20):5075-90. doi: 10.1113/jphysiol.2012.238352. Epub 2012 Aug 6.


Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila.

Wang CT, Zhang HG, Rocheleau TA, ffrench-Constant RH, Jackson MB.

Biophys J. 1999 Aug;77(2):691-700.


Effect of sensor domain mutations on the properties of voltage-gated ion channels: molecular dynamics studies of the potassium channel Kv1.2.

Delemotte L, Treptow W, Klein ML, Tarek M.

Biophys J. 2010 Nov 3;99(9):L72-4. doi: 10.1016/j.bpj.2010.08.069. Erratum in: Biophys J. 2011 Jan 5;100(1):269. Biophys J. 2010 Dec 1;99(11):3859.


S3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels.

Gonzalez C, Morera FJ, Rosenmann E, Alvarez O, Latorre R.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5020-5. Epub 2005 Mar 17.


Charge at the 46th residue of connexin 50 is crucial for the gap-junctional unitary conductance and transjunctional voltage-dependent gating.

Tong X, Aoyama H, Tsukihara T, Bai D.

J Physiol. 2014 Dec 1;592(23):5187-202. doi: 10.1113/jphysiol.2014.280636. Epub 2014 Sep 25.


Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy.

Maity S, Mazzolini M, Arcangeletti M, Valbuena A, Fabris P, Lazzarino M, Torre V.

Nat Commun. 2015 May 12;6:7093. doi: 10.1038/ncomms8093. Erratum in: Nat Commun. 2017 Sep 29;8:16162.


Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity.

Sheng S, McNulty KA, Harvey JM, Kleyman TR.

J Biol Chem. 2001 Nov 23;276(47):44091-8. Epub 2001 Sep 19.


Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.

Vemana S, Pandey S, Larsson HP.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C557-65. doi: 10.1152/ajpcell.00154.2008. Epub 2008 Jun 25.


Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.

McNulty MM, Edgerton GB, Shah RD, Hanck DA, Fozzard HA, Lipkind GM.

J Physiol. 2007 Jun 1;581(Pt 2):741-55. Epub 2007 Mar 15.


K+ channel selectivity depends on kinetic as well as thermodynamic factors.

Grabe M, Bichet D, Qian X, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14361-6. Epub 2006 Sep 18.


Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.

Yang J, Yu M, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1568-72.

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