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Items: 1 to 20 of 88

1.

The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini.

Hoffmeister H, Gallagher AR, Rascle A, Witzgall R.

Biochem J. 2011 Jan 15;433(2):285-94. doi: 10.1042/BJ20101141.

PMID:
21044049
2.

Polycystin-2--an intracellular or plasma membrane channel?

Witzgall R.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):342-7. Review.

PMID:
15747112
3.

Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells.

Scheffers MS, Le H, van der Bent P, Leonhard W, Prins F, Spruit L, Breuning MH, de Heer E, Peters DJ.

Hum Mol Genet. 2002 Jan 1;11(1):59-67.

PMID:
11772999
4.

Polycystins: polymodal receptor/ion-channel cellular sensors.

Delmas P.

Pflugers Arch. 2005 Oct;451(1):264-76. Epub 2005 May 12. Review.

PMID:
15889307
6.

Identification and characterization of polycystin-2, the PKD2 gene product.

Cai Y, Maeda Y, Cedzich A, Torres VE, Wu G, Hayashi T, Mochizuki T, Park JH, Witzgall R, Somlo S.

J Biol Chem. 1999 Oct 1;274(40):28557-65.

7.

Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).

Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ.

Eur J Hum Genet. 1999 Dec;7(8):860-72.

8.

Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene.

Foggensteiner L, Bevan AP, Thomas R, Coleman N, Boulter C, Bradley J, Ibraghimov-Beskrovnaya O, Klinger K, Sandford R.

J Am Soc Nephrol. 2000 May;11(5):814-27.

9.

Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2.

Molland KL, Narayanan A, Burgner JW, Yernool DA.

Biochem J. 2010 Jul 1;429(1):171-83. doi: 10.1042/BJ20091843.

PMID:
20408813
10.

Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.

Nomura H, Turco AE, Pei Y, Kalaydjieva L, Schiavello T, Weremowicz S, Ji W, Morton CC, Meisler M, Reeders ST, Zhou J.

J Biol Chem. 1998 Oct 2;273(40):25967-73.

11.

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling.

Li Y, Wright JM, Qian F, Germino GG, Guggino WB.

J Biol Chem. 2005 Dec 16;280(50):41298-306. Epub 2005 Oct 13.

12.

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.

Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG.

Nature. 2000 Dec 21-28;408(6815):990-4.

PMID:
11140688
13.

Autosomal dominant polycystic kidney disease: clues to pathogenesis.

Harris PC.

Hum Mol Genet. 1999;8(10):1861-6. Review.

PMID:
10469838
14.

The N-terminal extracellular domain is required for polycystin-1-dependent channel activity.

Babich V, Zeng WZ, Yeh BI, Ibraghimov-Beskrovnaya O, Cai Y, Somlo S, Huang CL.

J Biol Chem. 2004 Jun 11;279(24):25582-9. Epub 2004 Apr 1.

15.

Emerging issues of connexin channels: biophysics fills the gap.

Harris AL.

Q Rev Biophys. 2001 Aug;34(3):325-472. Review. Erratum in: Q Rev Biophys 2002 Feb;35(1):109.

PMID:
11838236
16.

A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.

Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.

J Biol Chem. 2009 Dec 4;284(49):34400-12. doi: 10.1074/jbc.M109.015149. Epub 2009 Oct 7.

17.

TRP channels and kidney disease: lessons from polycystic kidney disease.

Qamar S, Vadivelu M, Sandford R.

Biochem Soc Trans. 2007 Feb;35(Pt 1):124-8. Review.

PMID:
17233617
18.

Polycystin expression is temporally and spatially regulated during renal development.

Van Adelsberg J, Chamberlain S, D'Agati V.

Am J Physiol. 1997 May;272(5 Pt 2):F602-9.

PMID:
9176370
19.

Molecular basis of autosomal-dominant polycystic kidney disease.

Gallagher AR, Hidaka S, Gretz N, Witzgall R.

Cell Mol Life Sci. 2002 Apr;59(4):682-93. Review.

PMID:
12022474
20.

A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum.

Gao H, Sellin LK, Pütz M, Nickel C, Imgrund M, Gerke P, Nitschke R, Walz G, Kramer-Zucker AG.

Exp Cell Res. 2009 Apr 15;315(7):1157-70. doi: 10.1016/j.yexcr.2009.01.027. Epub 2009 Feb 10.

PMID:
19331813

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