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Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest.

Mikami I, Zhang F, Hirata T, Okamoto J, Koizumi K, Shimizu K, Jablons D, He B.

Oncol Rep. 2010 Dec;24(6):1677-81.


G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.

Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH.

Am J Physiol Cell Physiol. 2004 Aug;287(2):C281-91. Epub 2004 Mar 17.


Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma.

Mukohara T, Civiello G, Johnson BE, Janne PA.

Oncology. 2005;68(4-6):500-10. Epub 2005 Jul 13.


Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo.

Miyoshi S, Hamada H, Hamaguchi N, Kato A, Katayama H, Irifune K, Ito R, Miyazaki T, Okura T, Higaki J.

Int J Oncol. 2012 Aug;41(2):449-56. doi: 10.3892/ijo.2012.1462. Epub 2012 May 8.


BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells.

Banerji L, Glassford J, Lea NC, Thomas NS, Klaus GG, Lam EW.

Oncogene. 2001 Nov 1;20(50):7352-67.


Suppression of pro-metastasis phenotypes expression in malignant pleural mesothelioma by the PI3K inhibitor LY294002 or the MEK inhibitor UO126.

Cole GW Jr, Alleva AM, Zuo JT, Sehgal SS, Yeow WS, Schrump DS, Nguyen DM.

Anticancer Res. 2006 Mar-Apr;26(2A):809-21.


Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.

Koomoa DL, Yco LP, Borsics T, Wallick CJ, Bachmann AS.

Cancer Res. 2008 Dec 1;68(23):9825-31. doi: 10.1158/0008-5472.CAN-08-1865.


Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H.

Leuk Res. 2007 May;31(5):673-82. Epub 2006 Sep 27.


Human mesothelioma cells exhibit tumor cell-specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase.

Ramos-Nino ME, Vianale G, Sabo-Attwood T, Mutti L, Porta C, Heintz N, Mossman BT.

Mol Cancer Ther. 2005 May;4(5):835-42.


[Telomerase activity,PI3K/AKT signaling pathway and cellular biological behavior in HeLa cell line].

Yu XX, Shi YA, Zhang LH, Wang YS, Wu S.

Zhonghua Bing Li Xue Za Zhi. 2008 May;37(5):323-7. Chinese.


Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.

Uddin S, Hussain AR, Al-Hussein KA, Manogaran PS, Wickrema A, Gutierrez MI, Bhatia KG.

Clin Cancer Res. 2005 Apr 15;11(8):3102-8.


Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells.

Pitt SC, Chen H, Kunnimalaiyaan M.

J Am Coll Surg. 2009 Jul;209(1):82-8. doi: 10.1016/j.jamcollsurg.2009.03.006. Epub 2009 May 1.


Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002.

Kunnimalaiyaan M, Ndiaye M, Chen H.

Surgery. 2006 Dec;140(6):1009-14; discussion 1014-5. Epub 2006 Nov 1.


The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy.

Sourbier C, Lindner V, Lang H, Agouni A, Schordan E, Danilin S, Rothhut S, Jacqmin D, Helwig JJ, Massfelder T.

Cancer Res. 2006 May 15;66(10):5130-42.


LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity.

Gong C, Liao H, Wang J, Lin Y, Qi J, Qin L, Tian LQ, Guo FJ.

Asian Pac J Cancer Prev. 2012;13(7):3103-7.


Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription.

Han L, Yang Y, Yue X, Huang K, Liu X, Pu P, Jiang H, Yan W, Jiang T, Kang C.

Brain Res. 2010 Dec 17;1366:9-17. doi: 10.1016/j.brainres.2010.09.097. Epub 2010 Oct 1.


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