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Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms.

Salinthone S, Schillace RV, Tsang C, Regan JW, Bourdette DN, Carr DW.

J Nutr Biochem. 2011 Jul;22(7):681-90. doi: 10.1016/j.jnutbio.2010.05.008. Epub 2010 Oct 30.


Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells.

Salinthone S, Schillace RV, Marracci GH, Bourdette DN, Carr DW.

J Neuroimmunol. 2008 Aug 13;199(1-2):46-55. doi: 10.1016/j.jneuroim.2008.05.003. Epub 2008 Jun 17.


Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling.

Salinthone S, Yadav V, Schillace RV, Bourdette DN, Carr DW.

PLoS One. 2010 Sep 28;5(9). pii: e13058. doi: 10.1371/journal.pone.0013058.


Prostaglandin E2 Stimulates EP2, Adenylate Cyclase, Phospholipase C, and Intracellular Calcium Release to Mediate Cyclic Adenosine Monophosphate Production in Dental Pulp Cells.

Chang MC, Lin SI, Lin LD, Chan CP, Lee MS, Wang TM, Jeng PY, Yeung SY, Jeng JH.

J Endod. 2016 Apr;42(4):584-8. doi: 10.1016/j.joen.2015.12.011. Epub 2016 Feb 20.


α-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function.

Salinthone S, Kerns AR, Tsang V, Carr DW.

Mol Immunol. 2013 Mar;53(3):173-8. doi: 10.1016/j.molimm.2012.08.005. Epub 2012 Sep 1.


Dimethyl fumarate activates the prostaglandin EP2 receptor and stimulates cAMP signaling in human peripheral blood mononuclear cells.

Fiedler SE, Kerns AR, Tsang C, Tsang V, Bourdette D, Salinthone S.

Biochem Biophys Res Commun. 2016 Jun 17;475(1):19-24. doi: 10.1016/j.bbrc.2016.05.021. Epub 2016 May 5.


Lipoic acid stimulates cAMP production in T lymphocytes and NK cells.

Schillace RV, Pisenti N, Pattamanuch N, Galligan S, Marracci GH, Bourdette DN, Carr DW.

Biochem Biophys Res Commun. 2007 Mar 2;354(1):259-64. Epub 2007 Jan 3.


Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.

Bogard AS, Adris P, Ostrom RS.

J Pharmacol Exp Ther. 2012 Aug;342(2):586-95. doi: 10.1124/jpet.112.193425. Epub 2012 May 22.


Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 and EP4 receptors in human aortic smooth muscle cells.

Pantazaka E, Taylor EJ, Bernard WG, Taylor CW.

Br J Pharmacol. 2013 Aug;169(7):1624-34. doi: 10.1111/bph.12239.


Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.

Salinthone S, Yadav V, Bourdette DN, Carr DW.

Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):132-42. Review.


Prostaglandin E2 stimulates cystogenesis through EP4 receptor in IMCD-3 cells.

Elberg D, Turman MA, Pullen N, Elberg G.

Prostaglandins Other Lipid Mediat. 2012 May;98(1-2):11-6. doi: 10.1016/j.prostaglandins.2012.03.005. Epub 2012 Apr 6.


EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway.

Abera AB, Sales KJ, Catalano RD, Katz AA, Jabbour HN.

Cell Signal. 2010 Jan;22(1):71-9. doi: 10.1016/j.cellsig.2009.09.012. Epub 2009 Sep 25.


Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling.

Ivonnet P, Salathe M, Conner GE.

Br J Pharmacol. 2015 Jan;172(1):173-84. doi: 10.1111/bph.12934. Epub 2014 Dec 15.


Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase.

Ortiz-Capisano MC, Ortiz PA, Harding P, Garvin JL, Beierwaltes WH.

Hypertension. 2007 Jan;49(1):162-9. Epub 2006 Nov 6.


Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4.

Holt DM, Ma X, Kundu N, Collin PD, Fulton AM.

J Immunother. 2012 Feb-Mar;35(2):179-88. doi: 10.1097/CJI.0b013e318247a5e9.


Differential regulation of airway smooth muscle cell migration by E-prostanoid receptor subtypes.

Aso H, Ito S, Mori A, Suganuma N, Morioka M, Takahara N, Kondo M, Hasegawa Y.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):322-9. doi: 10.1165/rcmb.2012-0158OC. Epub 2012 Dec 6.


Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.

Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, Ostrom RS.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):359-69. Epub 2007 Oct 13.


Characterization of adenylyl cyclases in cultured human granulosa cells.

Asbóth G, Price SA, Bellinger J, Ledger W, Barlow DH, Bernal AL.

Reproduction. 2001 Feb;121(2):217-28.

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