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Items: 1 to 20 of 99

1.

Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.

Papeta N, Zheng Z, Schon EA, Brosel S, Altintas MM, Nasr SH, Reiser J, D'Agati VD, Gharavi AG.

J Clin Invest. 2010 Nov;120(11):4055-64. doi: 10.1172/JCI43721. Epub 2010 Oct 18.

2.
3.

[Slowing the progression of chronic renal insufficiency with captopril in rats with spontaneous arterial hypertension and adriamycin nephropathy].

Jovanović DB, Jovović Dj, Varagić J, Dimitrijević J, Dragojlović Z, Djukanović L.

Srp Arh Celok Lek. 2002 Mar-Apr;130(3-4):73-80. Serbian.

4.

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion.

Spinazzola A, Viscomi C, Fernandez-Vizarra E, Carrara F, D'Adamo P, Calvo S, Marsano RM, Donnini C, Weiher H, Strisciuglio P, Parini R, Sarzi E, Chan A, DiMauro S, Rötig A, Gasparini P, Ferrero I, Mootha VK, Tiranti V, Zeviani M.

Nat Genet. 2006 May;38(5):570-5. Epub 2006 Apr 2.

PMID:
16582910
5.

Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment.

Nithipongvanitch R, Ittarat W, Velez JM, Zhao R, St Clair DK, Oberley TD.

J Histochem Cytochem. 2007 Jun;55(6):629-39. Epub 2007 Feb 20.

PMID:
17312011
6.

Protective role of cyclosporine A and minocycline on mitochondrial disequilibrium-related podocyte injury and proteinuria occurrence induced by adriamycin.

Guan N, Ren YL, Liu XY, Zhang Y, Pei P, Zhu SN, Fan Q.

Nephrol Dial Transplant. 2015 Jun;30(6):957-69. doi: 10.1093/ndt/gfv015. Epub 2015 Feb 1.

PMID:
25646018
7.

A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse.

Zheng Z, Schmidt-Ott KM, Chua S, Foster KA, Frankel RZ, Pavlidis P, Barasch J, D'Agati VD, Gharavi AG.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2502-7. Epub 2005 Feb 7.

8.

Clinical, biochemical, cellular and molecular characterization of mitochondrial DNA depletion syndrome due to novel mutations in the MPV17 gene.

Uusimaa J, Evans J, Smith C, Butterworth A, Craig K, Ashley N, Liao C, Carver J, Diot A, Macleod L, Hargreaves I, Al-Hussaini A, Faqeih E, Asery A, Al Balwi M, Eyaid W, Al-Sunaid A, Kelly D, van Mourik I, Ball S, Jarvis J, Mulay A, Hadzic N, Samyn M, Baker A, Rahman S, Stewart H, Morris AA, Seller A, Fratter C, Taylor RW, Poulton J.

Eur J Hum Genet. 2014 Feb;22(2):184-91. doi: 10.1038/ejhg.2013.112. Epub 2013 May 29.

9.

Murine Prkdc polymorphisms impact DNA-PKcs function.

Fabre KM, Ramaiah L, Dregalla RC, Desaintes C, Weil MM, Bailey SM, Ullrich RL.

Radiat Res. 2011 Apr;175(4):493-500. doi: 10.1667/RR2431.1. Epub 2011 Jan 25.

10.

Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.

Zhou Z, Patel M, Ng N, Hsieh MH, Orth AP, Walker JR, Batalov S, Harris JL, Liu J.

BMC Cancer. 2014 Dec 13;14:944. doi: 10.1186/1471-2407-14-944.

12.

Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice.

Viscomi C, Spinazzola A, Maggioni M, Fernandez-Vizarra E, Massa V, Pagano C, Vettor R, Mora M, Zeviani M.

Hum Mol Genet. 2009 Jan 1;18(1):12-26. doi: 10.1093/hmg/ddn309. Epub 2008 Sep 24.

13.

Recessive mutations in MCM4/PRKDC cause a novel syndrome involving a primary immunodeficiency and a disorder of DNA repair.

Casey JP, Nobbs M, McGettigan P, Lynch S, Ennis S.

J Med Genet. 2012 Apr;49(4):242-5. doi: 10.1136/jmedgenet-2012-100803.

PMID:
22499342
14.

Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors.

Riabinska A, Daheim M, Herter-Sprie GS, Winkler J, Fritz C, Hallek M, Thomas RK, Kreuzer KA, Frenzel LP, Monfared P, Martins-Boucas J, Chen S, Reinhardt HC.

Sci Transl Med. 2013 Jun 12;5(189):189ra78. doi: 10.1126/scitranslmed.3005814.

15.

Mesenchymal stem cells protective effect in adriamycin model of nephropathy.

Magnasco A, Corselli M, Bertelli R, Ibatici A, Peresi M, Gaggero G, Cappiello V, Chiavarina B, Mattioli G, Gusmano R, Ravetti JL, Frassoni F, Ghiggeri GM.

Cell Transplant. 2008;17(10-11):1157-67.

PMID:
19181210
16.

Adriamycin nephropathy in BALB/c mice.

Wang YM, Wang Y, Harris DC, Alexander SI, Lee VW.

Curr Protoc Immunol. 2015 Feb 2;108:15.28.1-6. doi: 10.1002/0471142735.im1528s108.

PMID:
25640989
17.

Metallothionein over-expression in podocytes reduces adriamycin nephrotoxicity.

Yang L, Zheng S, Epstein PN.

Free Radic Res. 2009 Feb;43(2):174-82. doi: 10.1080/10715760802657308.

PMID:
19204870
18.

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.

Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ.

Mol Cancer Res. 2006 May;4(5):311-8.

19.

Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells.

Sun S, Cheng S, Zhu Y, Zhang P, Liu N, Xu T, Sun C, Lv Y.

Gene. 2016 Jun 10;584(1):90-6. doi: 10.1016/j.gene.2016.03.020. Epub 2016 Mar 15.

PMID:
26992638
20.

Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51.

Kujjo LL, Laine T, Pereira RJ, Kagawa W, Kurumizaka H, Yokoyama S, Perez GI.

PLoS One. 2010 Feb 12;5(2):e9204. doi: 10.1371/journal.pone.0009204.

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