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The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

Wallace SW, Magalhaes A, Hall A.

Mol Cell Biol. 2011 Jan;31(1):81-91. doi: 10.1128/MCB.01001-10. Epub 2010 Oct 25.


Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D.

Biochemistry. 2013 Nov 12;52(45):7999-8011. doi: 10.1021/bi401216w. Epub 2013 Oct 31.


Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B.

Wallace SW, Durgan J, Jin D, Hall A.

Mol Biol Cell. 2010 Sep 1;21(17):2996-3006. doi: 10.1091/mbc.E10-05-0429. Epub 2010 Jul 14.


The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.

Lim WG, Chen X, Liu JP, Tan BJ, Zhou S, Smith A, Lees N, Hou L, Gu F, Yu XY, Du Y, Smith D, Verma C, Liu K, Duan W.

Arch Biochem Biophys. 2008 Nov 15;479(2):170-8. doi: 10.1016/ Epub 2008 Sep 22.


Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.

Calautti E, Grossi M, Mammucari C, Aoyama Y, Pirro M, Ono Y, Li J, Dotto GP.

J Cell Biol. 2002 Jan 7;156(1):137-48. Epub 2002 Jan 3.


Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.

Schmidt A, Durgan J, Magalhaes A, Hall A.

EMBO J. 2007 Mar 21;26(6):1624-36. Epub 2007 Mar 1.


Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions.

Samarin SN, Ivanov AI, Flatau G, Parkos CA, Nusrat A.

Mol Biol Cell. 2007 Sep;18(9):3429-39. Epub 2007 Jun 27.


Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.

Terry SJ, Zihni C, Elbediwy A, Vitiello E, Leefa Chong San IV, Balda MS, Matter K.

Nat Cell Biol. 2011 Feb;13(2):159-66. doi: 10.1038/ncb2156. Epub 2011 Jan 23.


The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis.

Rogers KK, Jou TS, Guo W, Lipschutz JH.

Kidney Int. 2003 May;63(5):1632-44.


ROCK and Dia have opposing effects on adherens junctions downstream of Rho.

Sahai E, Marshall CJ.

Nat Cell Biol. 2002 Jun;4(6):408-15.


Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.

Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ.

J Biol Chem. 1996 Nov 15;271(46):28772-6.


Regulation of epithelial tubule formation by Rho family GTPases.

Eisen R, Walid S, Ratcliffe DR, Ojakian GK.

Am J Physiol Cell Physiol. 2006 May;290(5):C1297-309. Epub 2005 Dec 7.


Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions.

Omelchenko T, Hall A.

Curr Biol. 2012 Feb 21;22(4):278-88. doi: 10.1016/j.cub.2012.01.014. Epub 2012 Feb 2.


MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells.

Breznau EB, Semack AC, Higashi T, Miller AL.

Mol Biol Cell. 2015 Jul 1;26(13):2439-55. doi: 10.1091/mbc.E14-11-1553. Epub 2015 May 6.


A cross-link between protein kinase A and Rho-family GTPases signaling mediates cell-cell adhesion and actin cytoskeleton organization in epithelial cancer cells.

Leve F, de Souza W, Morgado-Díaz JA.

J Pharmacol Exp Ther. 2008 Dec;327(3):777-88. doi: 10.1124/jpet.108.140798. Epub 2008 Sep 12.


Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function.

Hopkins AM, Walsh SV, Verkade P, Boquet P, Nusrat A.

J Cell Sci. 2003 Feb 15;116(Pt 4):725-42.


Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function.

Arnold TR, Stephenson RE, Miller AL.

Exp Cell Res. 2017 Sep 1;358(1):20-30. doi: 10.1016/j.yexcr.2017.03.053. Epub 2017 Mar 29. Review.


LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.

Xu X, Jin D, Durgan J, Hall A.

Mol Cell Biol. 2013 Jul;33(14):2671-82. doi: 10.1128/MCB.00154-13. Epub 2013 May 6.

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