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Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans.

Lagger S, Meunier D, Mikula M, Brunmeir R, Schlederer M, Artaker M, Pusch O, Egger G, Hagelkruys A, Mikulits W, Weitzer G, Muellner EW, Susani M, Kenner L, Seiser C.

EMBO J. 2010 Dec 1;29(23):3992-4007. doi: 10.1038/emboj.2010.264. Epub 2010 Oct 22. Erratum in: EMBO J. 2011 Apr 20;30(8):1671.


The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.

Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C.

Mol Cell Biol. 2010 Mar;30(5):1171-81. doi: 10.1128/MCB.01500-09. Epub 2009 Dec 22.


Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin.

Hayashi A, Horiuchi A, Kikuchi N, Hayashi T, Fuseya C, Suzuki A, Konishi I, Shiozawa T.

Int J Cancer. 2010 Sep 1;127(6):1332-46. doi: 10.1002/ijc.25151.


HDAC1, a novel marker for benign teratomas.

Simboeck E, Di Croce L.

EMBO J. 2010 Dec 1;29(23):3893-5. doi: 10.1038/emboj.2010.281. Epub 2010 Dec 1. No abstract available.


EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin.

Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F, Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D.

Oncogene. 2012 Feb 2;31(5):583-94. doi: 10.1038/onc.2011.254. Epub 2011 Jun 20.


Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer.

Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn CO, Heidecke CD, Friess H, Büchler M, Evert M, Lerch MM, Weiss FU.

Gut. 2012 Mar;61(3):439-48. doi: 10.1136/gutjnl-2011-300060. Epub 2011 Dec 5.


Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.

Jurkin J, Zupkovitz G, Lagger S, Grausenburger R, Hagelkruys A, Kenner L, Seiser C.

Cell Cycle. 2011 Feb 1;10(3):406-12. Epub 2011 Feb 1.


E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.

von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G, Saur D.

Gastroenterology. 2009 Jul;137(1):361-71, 371.e1-5. doi: 10.1053/j.gastro.2009.04.004. Epub 2009 Apr 9.


Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation.

Dovey OM, Foster CT, Cowley SM.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8242-7. doi: 10.1073/pnas.1000478107. Epub 2010 Apr 19.


Negative and positive regulation of gene expression by mouse histone deacetylase 1.

Zupkovitz G, Tischler J, Posch M, Sadzak I, Ramsauer K, Egger G, Grausenburger R, Schweifer N, Chiocca S, Decker T, Seiser C.

Mol Cell Biol. 2006 Nov;26(21):7913-28. Epub 2006 Aug 28.


Histone deacetylase 1/Sp1/microRNA-200b signaling accounts for maintenance of cancer stem-like cells in human lung adenocarcinoma.

Chen DQ, Huang JY, Feng B, Pan BZ, De W, Wang R, Chen LB.

PLoS One. 2014 Oct 3;9(10):e109578. doi: 10.1371/journal.pone.0109578. eCollection 2014.


Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.

Jamaladdin S, Kelly RD, O'Regan L, Dovey OM, Hodson GE, Millard CJ, Portolano N, Fry AM, Schwabe JW, Cowley SM.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9840-5. doi: 10.1073/pnas.1321330111. Epub 2014 Jun 23.


Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins.

Pang M, Ma L, Liu N, Ponnusamy M, Zhao TC, Yan H, Zhuang S.

J Cell Biochem. 2011 Aug;112(8):2138-48. doi: 10.1002/jcb.23135.


HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation.

Huang Y, Chen J, Lu C, Han J, Wang G, Song C, Zhu S, Wang C, Li G, Kang J, Wang J.

Cell Death Dis. 2014 Oct 23;5:e1491. doi: 10.1038/cddis.2014.433.


Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms.

Pinkerneil M, Hoffmann MJ, Deenen R, Köhrer K, Arent T, Schulz WA, Niegisch G.

Mol Cancer Ther. 2016 Feb;15(2):299-312. doi: 10.1158/1535-7163.MCT-15-0618. Epub 2016 Jan 15.


Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: dual role of scaffold/matrix attachment region-binding protein 1 (SMAR1) in breast cancer cells.

Adhikary A, Chakraborty S, Mazumdar M, Ghosh S, Mukherjee S, Manna A, Mohanty S, Nakka KK, Joshi S, De A, Chattopadhyay S, Sa G, Das T.

J Biol Chem. 2014 Sep 12;289(37):25431-44. doi: 10.1074/jbc.M113.527267. Epub 2014 Aug 1.


The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis.

Turgeon N, Gagné JM, Blais M, Gendron FP, Boudreau F, Asselin C.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G594-605. doi: 10.1152/ajpgi.00393.2013. Epub 2014 Feb 13.


Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer.

Zhou W, Liang IC, Yee NS.

Cancer Biol Ther. 2011 Apr 1;11(7):659-70. Epub 2011 Apr 1.

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