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Sept4/ARTS is required for stem cell apoptosis and tumor suppression.

García-Fernández M, Kissel H, Brown S, Gorenc T, Schile AJ, Rafii S, Larisch S, Steller H.

Genes Dev. 2010 Oct 15;24(20):2282-93. doi: 10.1101/gad.1970110.


Peptides mimicking the unique ARTS-XIAP binding site promote apoptotic cell death in cultured cancer cells.

Edison N, Reingewertz TH, Gottfried Y, Lev T, Zuri D, Maniv I, Carp MJ, Shalev G, Friedler A, Larisch S.

Clin Cancer Res. 2012 May 1;18(9):2569-78. doi: 10.1158/1078-0432.CCR-11-1430. Epub 2012 Mar 5.


Regulation of apoptosis by XIAP ubiquitin-ligase activity.

Schile AJ, García-Fernández M, Steller H.

Genes Dev. 2008 Aug 15;22(16):2256-66. doi: 10.1101/gad.1663108.


The mitochondrial ARTS protein promotes apoptosis through targeting XIAP.

Gottfried Y, Rotem A, Lotan R, Steller H, Larisch S.

EMBO J. 2004 Apr 7;23(7):1627-35. Epub 2004 Mar 18.


ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists.

Bornstein B, Gottfried Y, Edison N, Shekhtman A, Lev T, Glaser F, Larisch S.

Apoptosis. 2011 Sep;16(9):869-81. doi: 10.1007/s10495-011-0622-0.


The Sept4 septin locus is required for sperm terminal differentiation in mice.

Kissel H, Georgescu MM, Larisch S, Manova K, Hunnicutt GR, Steller H.

Dev Cell. 2005 Mar;8(3):353-64.


Sept4/ARTS regulates stem cell apoptosis and skin regeneration.

Fuchs Y, Brown S, Gorenc T, Rodriguez J, Fuchs E, Steller H.

Science. 2013 Jul 19;341(6143):286-9. doi: 10.1126/science.1233029. Epub 2013 Jun 20.


Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP).

Dasari VR, Velpula KK, Kaur K, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

PLoS One. 2010 Jul 28;5(7):e11813. doi: 10.1371/journal.pone.0011813.


ARTS-based anticancer therapy: taking aim at cancer stem cells.

Elhasid R, Larisch S.

Future Oncol. 2011 Oct;7(10):1185-94. doi: 10.2217/fon.11.96. Review.


Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP.

Reingewertz TH, Shalev DE, Sukenik S, Blatt O, Rotem-Bamberger S, Lebendiker M, Larisch S, Friedler A.

PLoS One. 2011;6(9):e24655. doi: 10.1371/journal.pone.0024655. Epub 2011 Sep 20.


A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer.

Moon JH, Shin JS, Hong SW, Jung SA, Hwang IY, Kim JH, Choi EK, Ha SH, Kim JS, Kim KM, Hong DW, Kim D, Kim YS, Kim JE, Kim KP, Hong YS, Choi EK, Lee JS, Hattersley M, Jin DH, Kim TW.

Oncotarget. 2015 Sep 29;6(29):26895-908. doi: 10.18632/oncotarget.4822.


XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina.

Yao J, Feathers KL, Khanna H, Thompson D, Tsilfidis C, Hauswirth WW, Heckenlively JR, Swaroop A, Zacks DN.

Invest Ophthalmol Vis Sci. 2011 Mar 1;52(3):1567-72. doi: 10.1167/iovs.10-5998. Print 2011 Mar.


The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.

Edison N, Zuri D, Maniv I, Bornstein B, Lev T, Gottfried Y, Kemeny S, Garcia-Fernandez M, Kagan J, Larisch S.

Cell Death Differ. 2012 Feb;19(2):356-68. doi: 10.1038/cdd.2011.112. Epub 2011 Aug 26.


Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis.

Bi X, Feng D, Korczeniewska J, Alper N, Hu G, Barnes BJ.

Oncogene. 2014 Jun 19;33(25):3288-97. doi: 10.1038/onc.2013.295. Epub 2013 Aug 5.


HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells.

Lebert-Ghali CE, Fournier M, Dickson GJ, Thompson A, Sauvageau G, Bijl JJ.

Exp Hematol. 2010 Nov;38(11):1074-1086.e1-5. doi: 10.1016/j.exphem.2010.07.006. Epub 2010 Jul 23.


Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells.

Metwalli AR, Khanbolooki S, Jinesh G, Sundi D, Shah JB, Shrader M, Choi W, Lashinger LM, Chunduru S, McConkey DJ, McKinlay M, Kamat AM.

Cancer Biol Ther. 2010 Nov 1;10(9):885-92. doi: 10.4161/cbt.10.9.13237. Epub 2010 Nov 1.


The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis.

Chun KT, Li B, Dobrota E, Tate C, Lee JH, Khan S, Haneline L, HogenEsch H, Skalnik DG.

PLoS One. 2014 Dec 3;9(12):e113745. doi: 10.1371/journal.pone.0113745. eCollection 2014.

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