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Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.

Lombardo Y, Scopelliti A, Cammareri P, Todaro M, Iovino F, Ricci-Vitiani L, Gulotta G, Dieli F, de Maria R, Stassi G.

Gastroenterology. 2011 Jan;140(1):297-309. doi: 10.1053/j.gastro.2010.10.005. Epub 2010 Oct 14.


Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice.

Wang D, Fu L, Sun H, Guo L, DuBois RN.

Gastroenterology. 2015 Dec;149(7):1884-1895.e4. doi: 10.1053/j.gastro.2015.07.064. Epub 2015 Aug 7.


Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.

Moon BS, Jeong WJ, Park J, Kim TI, Min do S, Choi KY.

J Natl Cancer Inst. 2014 Feb;106(2):djt373. doi: 10.1093/jnci/djt373.


Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways.

Wang JY, Chang CC, Chiang CC, Chen WM, Hung SC.

J Cell Biochem. 2012 May;113(5):1733-43. doi: 10.1002/jcb.24043.


Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor.

Huang R, Wang G, Song Y, Tang Q, You Q, Liu Z, Chen Y, Zhang Q, Li J, Muhammand S, Wang X.

Mol Med Rep. 2015 Aug;12(2):2417-24. doi: 10.3892/mmr.2015.3694. Epub 2015 Apr 28.


BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma.

Zhang L, Sun H, Zhao F, Lu P, Ge C, Li H, Hou H, Yan M, Chen T, Jiang G, Xie H, Cui Y, Huang X, Fan J, Yao M, Li J.

Cancer Res. 2012 Aug 15;72(16):4276-85. doi: 10.1158/0008-5472.CAN-12-1013. Epub 2012 Jul 5.


Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.

Zhang B, Zhang B, Chen X, Bae S, Singh K, Washington MK, Datta PK.

Br J Cancer. 2014 Feb 18;110(4):946-57. doi: 10.1038/bjc.2013.789. Epub 2014 Jan 2.


The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway.

Kodach LL, Bleuming SA, Peppelenbosch MP, Hommes DW, van den Brink GR, Hardwick JC.

Gastroenterology. 2007 Oct;133(4):1272-81. Epub 2007 Aug 14.


Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition.

Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, van Buren G 2nd, Samuel S, Kim MP, Lim SJ, Ellis LM.

Cancer Res. 2009 Mar 1;69(5):1951-7. doi: 10.1158/0008-5472.CAN-08-2023. Epub 2009 Feb 24.


MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer.

Sheng WZ, Chen YS, Tu CT, He J, Zhang B, Gao WD.

World J Gastroenterol. 2016 Jun 28;22(24):5532-9. doi: 10.3748/wjg.v22.i24.5532.


Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade.

Zhang B, Leng C, Wu C, Zhang Z, Dou L, Luo X, Zhang B, Chen X.

Oncol Rep. 2016 Mar;35(3):1807-15. doi: 10.3892/or.2015.4479. Epub 2015 Dec 8.


Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, Biemond I, Verspaget HW, Hommes DW, de Rooij K, van Noesel CJ, Morreau H, van Wezel T, Offerhaus GJ, van den Brink GR, Peppelenbosch MP, Ten Dijke P, Hardwick JC.

Gastroenterology. 2014 Jul;147(1):196-208.e13. doi: 10.1053/j.gastro.2014.03.052. Epub 2014 Apr 3.


Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.

Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD.

Gastroenterology. 2012 Mar;142(3):562-571.e2. doi: 10.1053/j.gastro.2011.11.026. Epub 2011 Nov 22.


miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway.

Sun C, Wang FJ, Zhang HG, Xu XZ, Jia RC, Yao L, Qiao PF.

World J Gastroenterol. 2017 Mar 14;23(10):1816-1827. doi: 10.3748/wjg.v23.i10.1816.


Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice.

Rountree CB, Ding W, He L, Stiles B.

Stem Cells. 2009 Feb;27(2):290-9. doi: 10.1634/stemcells.2008-0332.


Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F, Vescovi AL.

Nature. 2006 Dec 7;444(7120):761-5.


Effects of metformin on CD133+ colorectal cancer cells in diabetic patients.

Zhang Y, Guan M, Zheng Z, Zhang Q, Gao F, Xue Y.

PLoS One. 2013 Nov 21;8(11):e81264. doi: 10.1371/journal.pone.0081264. eCollection 2013.


Nuclear orphan receptor NR4A2 confers chemoresistance and predicts unfavorable prognosis of colorectal carcinoma patients who received postoperative chemotherapy.

Han Y, Cai H, Ma L, Ding Y, Tan X, Liu Y, Su T, Yu Y, Chang W, Zhang H, Fu C, Cao G.

Eur J Cancer. 2013 Nov;49(16):3420-30. doi: 10.1016/j.ejca.2013.06.001. Epub 2013 Jun 25.


Omega-3 eicosapentaenoic acid decreases CD133 colon cancer stem-like cell marker expression while increasing sensitivity to chemotherapy.

De Carlo F, Witte TR, Hardman WE, Claudio PP.

PLoS One. 2013 Jul 16;8(7):e69760. doi: 10.1371/journal.pone.0069760. Print 2013.

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