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Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation.

Liu Y, Lo YC, Qian L, Crews FT, Wilson B, Chen HL, Wu HM, Chen SH, Wei K, Lu RB, Ali S, Hong JS.

Neuropharmacology. 2011 Feb-Mar;60(2-3):373-80. doi: 10.1016/j.neuropharm.2010.10.002. Epub 2010 Oct 13.


Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity.

Zhang D, Hu X, Wei SJ, Liu J, Gao H, Qian L, Wilson B, Liu G, Hong JS.

J Neuroinflammation. 2008 May 28;5:21. doi: 10.1186/1742-2094-5-21.


Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions.

Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM.

Mol Pharmacol. 2010 Sep;78(3):466-77. doi: 10.1124/mol.110.064535. Epub 2010 Jun 16. Erratum in: Mol Pharmacol. 2010 Nov;78(5):981.


3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity.

Zhang W, Qin L, Wang T, Wei SJ, Gao HM, Liu J, Wilson B, Liu B, Zhang W, Kim HC, Hong JS.

FASEB J. 2005 Mar;19(3):395-7. Epub 2004 Dec 13.


Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation.

Hu X, Zhou H, Zhang D, Yang S, Qian L, Wu HM, Chen PS, Wilson B, Gao HM, Lu RB, Hong JS.

J Neuroimmune Pharmacol. 2012 Mar;7(1):187-201. doi: 10.1007/s11481-011-9309-0. Epub 2011 Aug 26.


NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.

Qin L, Liu Y, Wang T, Wei SJ, Block ML, Wilson B, Liu B, Hong JS.

J Biol Chem. 2004 Jan 9;279(2):1415-21. Epub 2003 Oct 24.


Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity.

Qian L, Tan KS, Wei SJ, Wu HM, Xu Z, Wilson B, Lu RB, Hong JS, Flood PM.

J Immunol. 2007 Jul 15;179(2):1198-209.


Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress.

Yang S, Yang J, Yang Z, Chen P, Fraser A, Zhang W, Pang H, Gao X, Wilson B, Hong JS, Block ML.

J Pharmacol Exp Ther. 2006 Nov;319(2):595-603. Epub 2006 Aug 4.


Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?

Gao X, Hu X, Qian L, Yang S, Zhang W, Zhang D, Wu X, Fraser A, Wilson B, Flood PM, Block M, Hong JS.

Environ Health Perspect. 2008 May;116(5):593-8. doi: 10.1289/ehp.11031.


Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

Liu Y, Qin L, Li G, Zhang W, An L, Liu B, Hong JS.

J Pharmacol Exp Ther. 2003 Apr;305(1):212-8.


HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.

Gao HM, Zhou H, Zhang F, Wilson BC, Kam W, Hong JS.

J Neurosci. 2011 Jan 19;31(3):1081-92. doi: 10.1523/JNEUROSCI.3732-10.2011.


Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase.

Qian L, Block ML, Wei SJ, Lin CF, Reece J, Pang H, Wilson B, Hong JS, Flood PM.

J Pharmacol Exp Ther. 2006 Oct;319(1):44-52. Epub 2006 Jun 28.


Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection.

Qin L, Liu Y, Qian X, Hong JS, Block ML.

Ann N Y Acad Sci. 2005 Aug;1053:107-20.


Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

Li Y, Hu X, Liu Y, Bao Y, An L.

Neuropharmacology. 2009 Mar;56(3):580-9. doi: 10.1016/j.neuropharm.2008.10.016. Epub 2008 Nov 21.


A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis.

Jiang L, Chen SH, Chu CH, Wang SJ, Oyarzabal E, Wilson B, Sanders V, Xie K, Wang Q, Hong JS.

Glia. 2015 Jun;63(6):1057-72. doi: 10.1002/glia.22801. Epub 2015 Mar 4.


Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons.

Li FQ, Wang T, Pei Z, Liu B, Hong JS.

J Neural Transm (Vienna). 2005 Mar;112(3):331-47. Epub 2004 Oct 22.


β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway.

Qian L, Wu HM, Chen SH, Zhang D, Ali SF, Peterson L, Wilson B, Lu RB, Hong JS, Flood PM.

J Immunol. 2011 Apr 1;186(7):4443-54. doi: 10.4049/jimmunol.1002449. Epub 2011 Feb 18.


beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway.

Qian L, Hu X, Zhang D, Snyder A, Wu HM, Li Y, Wilson B, Lu RB, Hong JS, Flood PM.

Glia. 2009 Nov 15;57(15):1600-9. doi: 10.1002/glia.20873.


Aspirin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity in primary midbrain cultures.

Wang F, Zhai H, Huang L, Li H, Xu Y, Qiao X, Sun S, Wu Y.

J Mol Neurosci. 2012 Jan;46(1):153-61. doi: 10.1007/s12031-011-9541-3. Epub 2011 May 17.


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