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Items: 1 to 20 of 108

1.

Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesions.

Ma D, Li S, Lucas EK, Cowell RM, Lin JD.

J Biol Chem. 2010 Dec 10;285(50):39087-95. doi: 10.1074/jbc.M110.151688. Epub 2010 Oct 13.

2.

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.

Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.

Cell. 2004 Oct 1;119(1):121-35.

3.

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.

4.

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

PLoS Biol. 2005 Apr;3(4):e101. Epub 2005 Mar 15.

5.

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

Diabetes. 2009 Jul;58(7):1499-508. doi: 10.2337/db08-1571. Epub 2009 Apr 14.

6.

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

Ciron C, Lengacher S, Dusonchet J, Aebischer P, Schneider BL.

Hum Mol Genet. 2012 Apr 15;21(8):1861-76. doi: 10.1093/hmg/ddr618. Epub 2012 Jan 12.

7.

Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism.

Liu C, Li S, Liu T, Borjigin J, Lin JD.

Nature. 2007 May 24;447(7143):477-81. Epub 2007 May 2.

8.

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.

9.

Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.

Espinoza DO, Boros LG, Crunkhorn S, Gami H, Patti ME.

FASEB J. 2010 Apr;24(4):1003-14. doi: 10.1096/fj.09-133728. Epub 2009 Nov 11.

10.

The metabolic regulator PGC-1α directly controls the expression of the hypothalamic neuropeptide oxytocin.

Blechman J, Amir-Zilberstein L, Gutnick A, Ben-Dor S, Levkowitz G.

J Neurosci. 2011 Oct 19;31(42):14835-40. doi: 10.1523/JNEUROSCI.1798-11.2011.

11.

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D.

Cell. 2006 Oct 6;127(1):59-69.

12.

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, Auwerx J.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17187-92. doi: 10.1073/pnas.0808207105. Epub 2008 Oct 28.

14.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.

15.

Mitochondrial biogenesis and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is required.

Li L, Pan R, Li R, Niemann B, Aurich AC, Chen Y, Rohrbach S.

Diabetes. 2011 Jan;60(1):157-67. doi: 10.2337/db10-0331. Epub 2010 Oct 7.

16.

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM.

Cell. 2006 Oct 20;127(2):397-408.

17.

CCAAT/enhancer binding protein-beta is a transcriptional regulator of peroxisome-proliferator-activated receptor-gamma coactivator-1alpha in the regenerating liver.

Wang H, Peiris TH, Mowery A, Le Lay J, Gao Y, Greenbaum LE.

Mol Endocrinol. 2008 Jul;22(7):1596-605. doi: 10.1210/me.2007-0388. Epub 2008 May 8.

18.

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.

Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10086-91. Epub 2006 Jun 14.

19.

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.

Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD.

Cell Metab. 2005 Oct;2(4):227-38.

20.

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. doi: 10.1152/ajpendo.90292.2008. Epub 2009 Feb 10.

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