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Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

Yu A, Xing Y, Harrison SC, Kirchhausen T.

Structure. 2010 Oct 13;18(10):1311-20. doi: 10.1016/j.str.2010.07.010.


Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.

Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T.

Dev Cell. 2007 Jan;12(1):129-41.


Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.

Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20. doi: 10.1073/pnas.1114802109. Epub 2012 Mar 12.


In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos.

Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S.

J Cell Sci. 2014 Sep 15;127(Pt 18):3970-82. doi: 10.1242/jcs.148767. Epub 2014 Jul 29. Erratum in: J Cell Sci. 2014 Dec 15;127(24):5331.


Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.

Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, Mlodzik M, Shi DL, Zheng J.

Mol Cell. 2003 Nov;12(5):1251-60.


Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation.

Haucke V, Wenk MR, Chapman ER, Farsad K, De Camilli P.

EMBO J. 2000 Nov 15;19(22):6011-9.


Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

Punchihewa C, Ferreira AM, Cassell R, Rodrigues P, Fujii N.

Protein Sci. 2009 May;18(5):994-1002. doi: 10.1002/pro.109. Erratum in: Protein Sci. 2009 Jun;18(6):1333.


The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.

Boll W, Rapoport I, Brunner C, Modis Y, Prehn S, Kirchhausen T.

Traffic. 2002 Aug;3(8):590-600.


The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway.

Levecque C, Velayos-Baeza A, Holloway ZG, Monaco AP.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C160-8. doi: 10.1152/ajpcell.00630.2008. Epub 2009 May 6.


Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.

Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, Inaba D, Qiao S, Takada S, Kikuchi A, Minami Y.

Mol Cell Biol. 2010 Jul;30(14):3610-9. doi: 10.1128/MCB.00177-10. Epub 2010 May 10.


Functional domain mapping of the clathrin-associated adaptor medium chains mu1 and mu2.

Aguilar RC, Ohno H, Roche KW, Bonifacino JS.

J Biol Chem. 1997 Oct 24;272(43):27160-6.


Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase.

Jackson AP, Flett A, Smythe C, Hufton L, Wettey FR, Smythe E.

J Cell Biol. 2003 Oct 27;163(2):231-6.


ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.

He G, Gupta S, Yi M, Michaely P, Hobbs HH, Cohen JC.

J Biol Chem. 2002 Nov 15;277(46):44044-9. Epub 2002 Sep 8.


The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis.

Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S.

J Biol Chem. 2003 May 23;278(21):19331-40. Epub 2003 Mar 18.


Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.

Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ.

Science. 2003 Sep 5;301(5638):1391-4.


A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).

Terabayashi T, Funato Y, Fukuda M, Miki H.

J Biol Chem. 2009 Sep 25;284(39):26716-24. doi: 10.1074/jbc.M109.039313. Epub 2009 Jul 30.


The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.

Wei W, Li M, Wang J, Nie F, Li L.

Mol Cell Biol. 2012 Oct;32(19):3903-12. doi: 10.1128/MCB.00251-12. Epub 2012 Jul 23.


Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex.

Mardones GA, Burgos PV, Lin Y, Kloer DP, Magadán JG, Hurley JH, Bonifacino JS.

J Biol Chem. 2013 Mar 29;288(13):9563-71. doi: 10.1074/jbc.M113.450775. Epub 2013 Feb 12.


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