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Items: 1 to 20 of 145

1.

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.

Mol Cell. 2010 Oct 8;40(1):22-33. doi: 10.1016/j.molcel.2010.09.015.

2.

CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.

Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A.

Mol Cell. 2010 Oct 8;40(1):9-21. doi: 10.1016/j.molcel.2010.09.014.

3.

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.

Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.

J Cell Biol. 2011 Jan 10;192(1):43-54. doi: 10.1083/jcb.201009076.

4.

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.

Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D.

Mol Cell. 2010 Nov 12;40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28.

5.

CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.

Rizzardi LF, Coleman KE, Varma D, Matson JP, Oh S, Cook JG.

J Biol Chem. 2015 Jan 2;290(1):556-67. doi: 10.1074/jbc.M114.614701. Epub 2014 Nov 19.

6.

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.

Benamar M, Guessous F, Du K, Corbett P, Obeid J, Gioeli D, Slingluff CL Jr, Abbas T.

EBioMedicine. 2016 Aug;10:85-100. doi: 10.1016/j.ebiom.2016.06.023. Epub 2016 Jun 16.

7.
8.

CRL4(CDT2) targets CHK1 for PCNA-independent destruction.

Huh J, Piwnica-Worms H.

Mol Cell Biol. 2013 Jan;33(2):213-26. doi: 10.1128/MCB.00847-12. Epub 2012 Oct 29.

9.

CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.

Shibata E, Dar A, Dutta A.

J Biol Chem. 2014 Aug 15;289(33):23056-64. doi: 10.1074/jbc.M114.574210. Epub 2014 Jun 24.

10.

Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.

Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A.

Mol Cell Biol. 2011 Aug;31(15):3136-45. doi: 10.1128/MCB.05496-11. Epub 2011 May 31.

11.

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.

Havens CG, Walter JC.

Genes Dev. 2011 Aug 1;25(15):1568-82. doi: 10.1101/gad.2068611. Review.

12.

CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.

Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A.

Mol Cell. 2013 Mar 28;49(6):1147-58. doi: 10.1016/j.molcel.2013.02.003. Epub 2013 Mar 7.

13.

The histone methyltransferase SET8 is required for S-phase progression.

Jørgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sørensen CS.

J Cell Biol. 2007 Dec 31;179(7):1337-45. doi: 10.1083/jcb.200706150.

14.

A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang Z, Lee EY, Lee MY.

J Biol Chem. 2013 Oct 11;288(41):29550-61. doi: 10.1074/jbc.M113.490466. Epub 2013 Aug 2.

15.

Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.

Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC.

J Biol Chem. 2012 Mar 30;287(14):11410-21. doi: 10.1074/jbc.M111.337683. Epub 2012 Feb 2.

16.

Thymine DNA glycosylase is a CRL4Cdt2 substrate.

Slenn TJ, Morris B, Havens CG, Freeman RM Jr, Takahashi TS, Walter JC.

J Biol Chem. 2014 Aug 15;289(33):23043-55. doi: 10.1074/jbc.M114.574194. Epub 2014 Jun 19.

17.

A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.

Raman M, Havens CG, Walter JC, Harper JW.

Mol Cell. 2011 Oct 7;44(1):72-84. doi: 10.1016/j.molcel.2011.06.036.

18.

Sequential replication-coupled destruction at G1/S ensures genome stability.

Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG.

Genes Dev. 2015 Aug 15;29(16):1734-46. doi: 10.1101/gad.263731.115. Epub 2015 Aug 13.

19.

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.

Terai K, Abbas T, Jazaeri AA, Dutta A.

Mol Cell. 2010 Jan 15;37(1):143-9. doi: 10.1016/j.molcel.2009.12.018.

20.

Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

Shiomi Y, Hayashi A, Ishii T, Shinmyozu K, Nakayama J, Sugasawa K, Nishitani H.

Mol Cell Biol. 2012 Jun;32(12):2279-88. doi: 10.1128/MCB.06506-11. Epub 2012 Apr 9.

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