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Items: 1 to 20 of 169


Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.

Kohli RM, Maul RW, Guminski AF, McClure RL, Gajula KS, Saribasak H, McMahon MA, Siliciano RF, Gearhart PJ, Stivers JT.

J Biol Chem. 2010 Dec 24;285(52):40956-64. doi: 10.1074/jbc.M110.177402. Epub 2010 Oct 6.


B-cell agonists up-regulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti-viral function.

Seidl T, Whittall T, Babaahmady K, Lehner T.

Immunology. 2012 Mar;135(3):207-15. doi: 10.1111/j.1365-2567.2011.03524.x.


A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.

Kohli RM, Abrams SR, Gajula KS, Maul RW, Gearhart PJ, Stivers JT.

J Biol Chem. 2009 Aug 21;284(34):22898-904. doi: 10.1074/jbc.M109.025536. Epub 2009 Jun 26.


Dissecting APOBEC3G substrate specificity by nucleoside analog interference.

Rausch JW, Chelico L, Goodman MF, Le Grice SF.

J Biol Chem. 2009 Mar 13;284(11):7047-58. doi: 10.1074/jbc.M807258200. Epub 2009 Jan 9.


Determinants of sequence-specificity within human AID and APOBEC3G.

Carpenter MA, Rajagurubandara E, Wijesinghe P, Bhagwat AS.

DNA Repair (Amst). 2010 May 4;9(5):579-87. doi: 10.1016/j.dnarep.2010.02.010. Epub 2010 Mar 24.


Comparative analysis of the gene-inactivating potential of retroviral restriction factors APOBEC3F and APOBEC3G.

Bélanger K, Langlois MA.

J Gen Virol. 2015 Sep;96(9):2878-87. doi: 10.1099/vir.0.000214. Epub 2015 Jun 5.


AID and Apobec3G haphazard deamination and mutational diversity.

Jaszczur M, Bertram JG, Pham P, Scharff MD, Goodman MF.

Cell Mol Life Sci. 2013 Sep;70(17):3089-108. doi: 10.1007/s00018-012-1212-1. Epub 2012 Nov 22. Review.


Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo.

Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS.

J Mol Biol. 2004 Mar 26;337(3):585-96.


The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells.

Casartelli N, Guivel-Benhassine F, Bouziat R, Brandler S, Schwartz O, Moris A.

J Exp Med. 2010 Jan 18;207(1):39-49. doi: 10.1084/jem.20091933. Epub 2009 Dec 28.


DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315.

Polevoda B, Joseph R, Friedman AE, Bennett RP, Greiner R, De Zoysa T, Stewart RA, Smith HC.

J Biol Chem. 2017 May 26;292(21):8642-8656. doi: 10.1074/jbc.M116.767889. Epub 2017 Apr 5.


RNA-binding residues in the N-terminus of APOBEC3G influence its DNA sequence specificity and retrovirus restriction efficiency.

Bélanger K, Langlois MA.

Virology. 2015 Sep;483:141-8. doi: 10.1016/j.virol.2015.04.019. Epub 2015 May 15.


Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction.

He Z, Zhang W, Chen G, Xu R, Yu XF.

J Mol Biol. 2008 Sep 12;381(4):1000-11. doi: 10.1016/j.jmb.2008.06.061. Epub 2008 Jun 28.


The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.

Hu C, Saenz DT, Fadel HJ, Walker W, Peretz M, Poeschla EM.

J Virol. 2010 Nov;84(22):11981-93. doi: 10.1128/JVI.00723-10. Epub 2010 Sep 15.


Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cells.

Monajemi M, Woodworth CF, Zipperlen K, Gallant M, Grant MD, Larijani M.

PLoS One. 2014 Apr 10;9(4):e93428. doi: 10.1371/journal.pone.0093428. eCollection 2014.


The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication.

Wang X, Ao Z, Chen L, Kobinger G, Peng J, Yao X.

J Virol. 2012 Apr;86(7):3777-86. doi: 10.1128/JVI.06594-11. Epub 2012 Feb 1.


Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus.

Chen Z, Eggerman TL, Bocharov AV, Baranova IN, Vishnyakova TG, Kurlander R, Patterson AP.

J Biol Chem. 2017 Aug 11;292(32):13459-13479. doi: 10.1074/jbc.M116.760637. Epub 2017 Jun 21.


The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques.

Wang Y, Whittall T, Rahman D, Bunnik EM, Vaughan R, Schøller J, Bergmeier LA, Montefiori D, Singh M, Schuitemaker H, Lehner T.

PLoS One. 2012;7(4):e34433. doi: 10.1371/journal.pone.0034433. Epub 2012 Apr 13.


The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.

Rathore A, Carpenter MA, Demir Ö, Ikeda T, Li M, Shaban NM, Law EK, Anokhin D, Brown WL, Amaro RE, Harris RS.

J Mol Biol. 2013 Nov 15;425(22):4442-54. doi: 10.1016/j.jmb.2013.07.040. Epub 2013 Aug 11.


Multifaceted antiviral actions of APOBEC3 cytidine deaminases.

Chiu YL, Greene WC.

Trends Immunol. 2006 Jun;27(6):291-7. Epub 2006 May 4. Review.


Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.

Conticello SG, Thomas CJ, Petersen-Mahrt SK, Neuberger MS.

Mol Biol Evol. 2005 Feb;22(2):367-77. Epub 2004 Oct 20.


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