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Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+.

Eltit JM, Feng W, Lopez JR, Padilla IT, Pessah IN, Molinski TF, Fruen BR, Allen PD, Perez CF.

J Biol Chem. 2010 Dec 3;285(49):38453-62. doi: 10.1074/jbc.M110.164525. Epub 2010 Oct 6.


Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction.

Eltit JM, Szpyt J, Li H, Allen PD, Perez CF.

Cell Calcium. 2011 Feb;49(2):128-35. doi: 10.1016/j.ceca.2011.01.005.


Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation contraction coupling.

Goonasekera SA, Beard NA, Groom L, Kimura T, Lyfenko AD, Rosenfeld A, Marty I, Dulhunty AF, Dirksen RT.

J Gen Physiol. 2007 Oct;130(4):365-78. Epub 2007 Sep 10.


Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak.

Eltit JM, Li H, Ward CW, Molinski T, Pessah IN, Allen PD, Lopez JR.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7046-51. doi: 10.1073/pnas.1018380108. Epub 2011 Apr 11.


Occurrence of atypical Ca2+ transients in triadin-binding deficient-RYR1 mutants.

Lee EH, Song DW, Lee JM, Meissner G, Allen PD, Kim DH.

Biochem Biophys Res Commun. 2006 Dec 29;351(4):909-14. Epub 2006 Nov 7.


Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.

Wang Y, Li X, Duan H, Fulton TR, Eu JP, Meissner G.

Cell Calcium. 2009 Jan;45(1):29-37. doi: 10.1016/j.ceca.2008.05.006. Epub 2008 Jul 11.


RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes.

Eltit JM, Yang T, Li H, Molinski TF, Pessah IN, Allen PD, Lopez JR.

J Biol Chem. 2010 Apr 30;285(18):13781-7. doi: 10.1074/jbc.M110.107300. Epub 2010 Mar 5.


Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.

Feng W, Barrientos GC, Cherednichenko G, Yang T, Padilla IT, Truong K, Allen PD, Lopez JR, Pessah IN.

Mol Pharmacol. 2011 Mar;79(3):420-31. doi: 10.1124/mol.110.067959. Epub 2010 Dec 14.


Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle.

Shen X, Franzini-Armstrong C, Lopez JR, Jones LR, Kobayashi YM, Wang Y, Kerrick WG, Caswell AH, Potter JD, Miller T, Allen PD, Perez CF.

J Biol Chem. 2007 Dec 28;282(52):37864-74. Epub 2007 Nov 2.


Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle.

Barrientos GC, Feng W, Truong K, Matthaei KI, Yang T, Allen PD, Lopez JR, Pessah IN.

J Biol Chem. 2012 Jan 20;287(4):2863-76. doi: 10.1074/jbc.M111.307926. Epub 2011 Dec 2.


Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle.

Perez CF, López JR, Allen PD.

Am J Physiol Cell Physiol. 2005 Mar;288(3):C640-9. Epub 2004 Nov 17.


FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes.

Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT.

J Biol Chem. 2003 Jun 20;278(25):22600-8. Epub 2003 Apr 17.


Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR.

Yang T, Esteve E, Pessah IN, Molinski TF, Allen PD, López JR.

Am J Physiol Cell Physiol. 2007 May;292(5):C1591-8. Epub 2006 Dec 20.


Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis.

Boncompagni S, Thomas M, Lopez JR, Allen PD, Yuan Q, Kranias EG, Franzini-Armstrong C, Perez CF.

PLoS One. 2012;7(7):e39962. doi: 10.1371/journal.pone.0039962. Epub 2012 Jul 2.


Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin.

Wei L, Gallant EM, Dulhunty AF, Beard NA.

Int J Biochem Cell Biol. 2009 Nov;41(11):2214-24. doi: 10.1016/j.biocel.2009.04.017. Epub 2009 May 4.


Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle.

Bannister RA, Beam KG.

J Muscle Res Cell Motil. 2009;30(5-6):217-23. doi: 10.1007/s10974-009-9190-0. Epub 2009 Oct 3.


Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6.

Goonasekera SA, Chen SR, Dirksen RT.

Am J Physiol Cell Physiol. 2005 Dec;289(6):C1476-84. Epub 2005 Jul 27.


Ca2+ release in muscle fibers expressing R4892W and G4896V type 1 ryanodine receptor disease mutants.

Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V.

PLoS One. 2013;8(1):e54042. doi: 10.1371/journal.pone.0054042. Epub 2013 Jan 7.


Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107.

Mei Y, Xu L, Kramer HF, Tomberlin GH, Townsend C, Meissner G.

PLoS One. 2013;8(1):e54208. doi: 10.1371/journal.pone.0054208. Epub 2013 Jan 17.


FKBP12 binding modulates ryanodine receptor channel gating.

Gaburjakova M, Gaburjakova J, Reiken S, Huang F, Marx SO, Rosemblit N, Marks AR.

J Biol Chem. 2001 May 18;276(20):16931-5. Epub 2001 Mar 1.

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