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Clopidogrel with or without omeprazole in coronary artery disease.

Bhatt DL, Cryer BL, Contant CF, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Scirica BM, Murphy SA, Cannon CP; COGENT Investigators.

N Engl J Med. 2010 Nov 11;363(20):1909-17. doi: 10.1056/NEJMoa1007964. Epub 2010 Oct 6.


Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy.

Vaduganathan M, Bhatt DL, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Cannon CP; COGENT Investigators.

J Am Coll Cardiol. 2016 Apr 12;67(14):1661-71. doi: 10.1016/j.jacc.2015.12.068. Epub 2016 Mar 21.


Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial.

Vaduganathan M, Cannon CP, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Bhatt DL; COGENT Investigators.

Am J Med. 2016 Sep;129(9):1002-5. doi: 10.1016/j.amjmed.2016.03.042. Epub 2016 Apr 30.


Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study.

Ray WA, Murray KT, Griffin MR, Chung CP, Smalley WE, Hall K, Daugherty JR, Kaltenbach LA, Stein CM.

Ann Intern Med. 2010 Mar 16;152(6):337-45. doi: 10.7326/0003-4819-152-6-201003160-00003.


Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting.

Ma B, Hang L, Chen G, Du Y.

West Indian Med J. 2013 Feb;62(2):135-9.


Clopidogrel with or without omeprazole in coronary disease.

Juurlink DN.

N Engl J Med. 2011 Feb 17;364(7):681-2; author reply 682-3. doi: 10.1056/NEJMc1013859#SA2. No abstract available.


Clopidogrel and proton pump inhibitors--where do we stand in 2012?

Drepper MD, Spahr L, Frossard JL.

World J Gastroenterol. 2012 May 14;18(18):2161-71. doi: 10.3748/wjg.v18.i18.2161. Review.


Clopidogrel and PPI interaction: clinically relevant or not?

Harrison RW, Mahaffey KW.

Curr Cardiol Rep. 2012 Feb;14(1):49-58. doi: 10.1007/s11886-011-0233-y. Review.


Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel.

Sibbing D, Morath T, Stegherr J, Braun S, Vogt W, Hadamitzky M, Schömig A, Kastrati A, von Beckerath N.

Thromb Haemost. 2009 Apr;101(4):714-9.


A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding.

Hsiao FY, Tsai YW, Huang WF, Wen YW, Chen PF, Chang PY, Kuo KN.

Clin Ther. 2009 Sep;31(9):2038-47. doi: 10.1016/j.clinthera.2009.09.005.


[Dilemma between gastroprotection and cardiovascular prevention].

Venerito M, Kandulski A, Malfertheiner P.

Dtsch Med Wochenschr. 2010 Nov;135(44):2193-8. doi: 10.1055/s-0030-1267498. Epub 2010 Oct 26. Review. German.


Effect of individual proton pump inhibitors on cardiovascular events in patients treated with clopidogrel following coronary stenting: results from the Ibaraki Cardiac Assessment Study Registry.

Aihara H, Sato A, Takeyasu N, Nishina H, Hoshi T, Akiyama D, Kakefuda Y, Watabe H, Aonuma K; ICAS Registry Investigators.

Catheter Cardiovasc Interv. 2012 Oct 1;80(4):556-63. doi: 10.1002/ccd.23327. Epub 2012 Jan 10.


Relationship between cardiovascular outcomes and proton pump inhibitor use in patients receiving dual antiplatelet therapy after acute coronary syndrome.

Hsiao FY, Mullins CD, Wen YW, Huang WF, Chen PF, Tsai YW.

Pharmacoepidemiol Drug Saf. 2011 Oct;20(10):1043-9. doi: 10.1002/pds.2202. Epub 2011 Aug 8.


Current standings of the proton pump inhibitor and clopidogrel co-therapy: review on an evolving field with the eyes of the gastroenterologist.

Juhász M, Herszényi L, Tulassay Z.

Digestion. 2010;81(1):10-5. doi: 10.1159/000243717. Epub 2009 Dec 22. Review.


The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial.

Vardi M, Cryer BL, Cohen M, Lanas A, Schnitzer TJ, Lapuerta P, Goldsmith MA, Laine L, Doros G, Liu Y, McIntosh AI, Cannon CP, Bhatt DL.

Aliment Pharmacol Ther. 2015 Aug;42(3):365-74. doi: 10.1111/apt.13260. Epub 2015 May 29.


Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review.

Sherwood MW, Melloni C, Jones WS, Washam JB, Hasselblad V, Dolor RJ.

J Am Heart Assoc. 2015 Oct 29;4(11). pii: e002245. doi: 10.1161/JAHA.115.002245. Review.


Interaction of clopidogrel and omeprazole.

Southworth MR, Temple R.

N Engl J Med. 2010 Nov 11;363(20):1977. doi: 10.1056/NEJMc1012022. No abstract available.


Analysis of gastrointestinal prophylaxis in patients receiving dual antiplatelet therapy with aspirin and clopidogrel.

Morneau KM, Reaves AB, Martin JB, Oliphant CS.

J Manag Care Pharm. 2014 Feb;20(2):187-93.


Effects of PPIs and an H2 blocker on the antiplatelet function of clopidogrel in Japanese patients under dual antiplatelet therapy.

Yamane K, Kato Y, Tazaki J, Tada T, Makiyama T, Imai M, Jinnai T, Ikeda T, Shirakawa R, Kimura T, Horiuchi H.

J Atheroscler Thromb. 2012;19(6):559-69. Epub 2012 Apr 4.

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