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Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.

Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC.

Oncogene. 2011 Feb 10;30(6):724-36. doi: 10.1038/onc.2010.445. Epub 2010 Oct 4.


Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.

Akiyoshi Y, Clayton J, Phan L, Yamamoto M, Hinnebusch AG, Watanabe Y, Asano K.

J Biol Chem. 2001 Mar 30;276(13):10056-62. Epub 2000 Dec 27.


Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.

Gillis LD, Lewis SM.

Oncogene. 2013 Aug 1;32(31):3598-605. doi: 10.1038/onc.2012.371. Epub 2012 Aug 20.


INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.

Neusiedler J, Mocquet V, Limousin T, Ohlmann T, Morris C, Jalinot P.

RNA. 2012 Jun;18(6):1163-77. doi: 10.1261/rna.032631.112. Epub 2012 Apr 24.


Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.

Buchsbaum S, Morris C, Bochard V, Jalinot P.

Oncogene. 2007 Aug 2;26(35):5132-44. Epub 2007 Feb 19.


Human INT6/eIF3e is required for nonsense-mediated mRNA decay.

Morris C, Wittmann J, Jäck HM, Jalinot P.

EMBO Rep. 2007 Jun;8(6):596-602. Epub 2007 Apr 20.


Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts.

Watkins SJ, Norbury CJ.

Cell Prolif. 2004 Apr;37(2):149-60.


Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.

Sesen J, Cammas A, Scotland SJ, Elefterion B, Lemarié A, Millevoi S, Mathew LK, Seva C, Toulas C, Moyal EC, Skuli N.

Int J Mol Sci. 2014 Jan 29;15(2):2172-90. doi: 10.3390/ijms15022172.


Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α.

Trausch-Azar JS, Abed M, Orian A, Schwartz AL.

J Cell Physiol. 2015 Apr;230(4):842-52. doi: 10.1002/jcp.24812.


INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells.

Morris C, Tomimatsu N, Richard DJ, Cluet D, Burma S, Khanna KK, Jalinot P.

Cancer Res. 2012 Apr 15;72(8):2006-16. doi: 10.1158/0008-5472.CAN-11-2562.


Int6/eIF3e silenced HIF2α stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling.

Endler A, Chen L, Li Q, Uchida K, Hashimoto T, Lu L, Xu GT, Shibasaki F.

Cytokine. 2013 Apr;62(1):115-22. doi: 10.1016/j.cyto.2013.01.021. Epub 2013 Mar 9.


Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.

Udagawa T, Nemoto N, Wilkinson CR, Narashimhan J, Jiang L, Watt S, Zook A, Jones N, Wek RC, Bähler J, Asano K.

J Biol Chem. 2008 Aug 8;283(32):22063-75. doi: 10.1074/jbc.M710017200. Epub 2008 May 23.


The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ.

Zhang W, MacDonald EM, Koepp DM.

PLoS One. 2012;7(10):e47736. doi: 10.1371/journal.pone.0047736. Epub 2012 Oct 17.


Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation.

Yahalom A, Kim TH, Roy B, Singer R, von Arnim AG, Chamovitz DA.

Plant J. 2008 Jan;53(2):300-11. Epub 2007 Dec 4.


The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.

Biswas M, Phan D, Watanabe M, Chan JY.

J Biol Chem. 2011 Nov 11;286(45):39282-9. doi: 10.1074/jbc.M111.253807. Epub 2011 Sep 27.


The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.

Zhao D, Zheng HQ, Zhou Z, Chen C.

Cancer Res. 2010 Jun 1;70(11):4728-38. doi: 10.1158/0008-5472.CAN-10-0040. Epub 2010 May 18.

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