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Items: 1 to 20 of 196

1.

Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.

Amodio N, Scrima M, Palaia L, Salman AN, Quintiero A, Franco R, Botti G, Pirozzi P, Rocco G, De Rosa N, Viglietto G.

Am J Pathol. 2010 Nov;177(5):2622-34. doi: 10.2353/ajpath.2010.091075. Epub 2010 Oct 1.

2.

Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.

Sun H, Ma H, Wang J, Xia L, Zhu G, Wang Z, Sun J, Chen Z.

Tumour Biol. 2017 Jul;39(7):1010428317709639. doi: 10.1177/1010428317709639.

PMID:
28714370
3.

PTEN and NEDD4 in Human Breast Carcinoma.

Chen Y, van de Vijver MJ, Hibshoosh H, Parsons R, Saal LH.

Pathol Oncol Res. 2016 Jan;22(1):41-7. doi: 10.1007/s12253-015-9971-2. Epub 2015 Aug 15.

4.

p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.

Hong SW, Moon JH, Kim JS, Shin JS, Jung KA, Lee WK, Jeong SY, Hwang JJ, Lee SJ, Suh YA, Kim I, Nam KY, Han S, Kim JE, Kim KP, Hong YS, Lee JL, Lee WJ, Choi EK, Lee JS, Jin DH, Kim TW.

Cell Death Differ. 2014 Jan;21(1):146-60. doi: 10.1038/cdd.2013.141. Epub 2013 Oct 18.

5.

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E.

Cell Signal. 2013 Jan;25(1):12-8. doi: 10.1016/j.cellsig.2012.08.012. Epub 2012 Sep 5.

PMID:
22974840
6.

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.

Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W.

Oncotarget. 2014 Feb 28;5(4):1026-37.

7.

ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.

Leonard MK, Hill NT, Grant ED, Kadakia MP.

Arch Dermatol Res. 2013 Oct;305(8):733-9. doi: 10.1007/s00403-013-1352-7. Epub 2013 Apr 16.

8.

The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.

Ahn Y, Hwang CY, Lee SR, Kwon KS, Lee C.

Biochem J. 2008 Jun 1;412(2):331-8. doi: 10.1042/BJ20071403.

PMID:
18307411
9.

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.

Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D.

Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8585-90. doi: 10.1073/pnas.0803233105. Epub 2008 Jun 18.

10.

Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.

Li H, Mohamed AA, Sharad S, Umeda E, Song Y, Young D, Petrovics G, McLeod DG, Sesterhenn IA, Sreenath T, Dobi A, Srivastava S.

Oncotarget. 2015 Jun 20;6(17):15137-49.

11.

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X.

Cell. 2007 Jan 12;128(1):129-39.

12.

Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

Zeng T, Wang Q, Fu J, Lin Q, Bi J, Ding W, Qiao Y, Zhang S, Zhao W, Lin H, Wang M, Lu B, Deng X, Zhou D, Yin Z, Wang HR.

Cell Rep. 2014 May 8;7(3):871-82. doi: 10.1016/j.celrep.2014.03.045. Epub 2014 Apr 17.

13.

Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation.

Wang X, Shi Y, Wang J, Huang G, Jiang X.

Biochem J. 2008 Sep 1;414(2):221-9. doi: 10.1042/BJ20080674.

PMID:
18498243
14.

Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.

Kwak YD, Wang B, Pan W, Xu H, Jiang X, Liao FF.

J Biol Chem. 2010 Mar 26;285(13):9847-57. doi: 10.1074/jbc.M109.091637. Epub 2010 Jan 25.

15.

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.

Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA.

Biochemistry. 2016 Jul 5;55(26):3658-66. doi: 10.1021/acs.biochem.6b00448. Epub 2016 Jun 22.

16.

NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.

Hang X, Zhu S, Di H, Wu Z, Chu K, Wang J, Xin H, Yu G, Peng H, Miao X, Xu W.

Cell Physiol Biochem. 2016;39(2):768-79. doi: 10.1159/000445667. Epub 2016 Jul 29.

17.

Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.

Christie KJ, Martinez JA, Zochodne DW.

Mol Cell Neurosci. 2012 Jun;50(2):179-92. doi: 10.1016/j.mcn.2012.04.006. Epub 2012 Apr 26.

PMID:
22561198
18.

The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.

Weng M, Luo ZL, Wu XL, Zeng WZ.

Oncotarget. 2017 Mar 21;8(12):20288-20296. doi: 10.18632/oncotarget.15446.

19.

E3 ligase Nedd4 promotes axon branching by downregulating PTEN.

Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE.

Neuron. 2010 Feb 11;65(3):341-57. doi: 10.1016/j.neuron.2010.01.017.

20.

Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.

Shao C, Li Z, Ahmad N, Liu X.

Cell Cycle. 2017 May 19;16(10):957-967. doi: 10.1080/15384101.2017.1310351. Epub 2017 Apr 24.

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