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Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim.

Meng J, Fang B, Liao Y, Chresta CM, Smith PD, Roth JA.

PLoS One. 2010 Sep 27;5(9):e13026. doi: 10.1371/journal.pone.0013026.


MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.

Pei XY, Dai Y, Tenorio S, Lu J, Harada H, Dent P, Grant S.

Blood. 2007 Sep 15;110(6):2092-101. Epub 2007 May 31.


The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma.

Bhalla S, Evens AM, Dai B, Prachand S, Gordon LI, Gartenhaus RB.

Blood. 2011 Jul 28;118(4):1052-61. doi: 10.1182/blood-2011-03-340109. Epub 2011 May 31.


Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.

Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC.

Cancer Res. 2010 Jun 1;70(11):4709-18. doi: 10.1158/0008-5472.CAN-09-4524. Epub 2010 May 18.


Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation.

Song JY, Kim CS, Lee JH, Jang SJ, Lee SW, Hwang JJ, Lim C, Lee G, Seo J, Cho SY, Choi J.

Invest New Drugs. 2013 Dec;31(6):1458-65. doi: 10.1007/s10637-013-0030-0. Epub 2013 Sep 26.


18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.

Sharma G, Kar S, Palit S, Das PK.

J Cell Physiol. 2012 May;227(5):1923-31. doi: 10.1002/jcp.22920.


BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells.

Yuan Z, Wang F, Zhao Z, Zhao X, Qiu J, Nie C, Wei Y.

PLoS One. 2011;6(5):e20586. doi: 10.1371/journal.pone.0020586. Epub 2011 May 31.


Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo.

Stan SD, Hahm ER, Warin R, Singh SV.

Cancer Res. 2008 Sep 15;68(18):7661-9. doi: 10.1158/0008-5472.CAN-08-1510.


8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells.

Ding Q, Chen Y, Zhang Q, Guo Y, Huang Z, Dai L, Cao S.

Mol Med Rep. 2015 Oct;12(4):5100-8. doi: 10.3892/mmr.2015.4039. Epub 2015 Jul 3.


Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.

Kawabata T, Tanimura S, Asai K, Kawasaki R, Matsumaru Y, Kohno M.

J Biol Chem. 2012 Mar 23;287(13):10289-300. doi: 10.1074/jbc.M111.319426. Epub 2012 Jan 23.


Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ.

Sci Signal. 2011 Mar 29;4(166):ra17. doi: 10.1126/scisignal.2001752. Erratum in: Sci Signal. 2011;4(170). doi:10.1126/scisignal.4170er2. Corrected and republished in: Sci Signal. 2011;4(170):er2.


Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.

Balmanno K, Chell SD, Gillings AS, Hayat S, Cook SJ.

Int J Cancer. 2009 Nov 15;125(10):2332-41. doi: 10.1002/ijc.24604.


Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells.

Carbajo-Pescador S, Steinmetz C, Kashyap A, Lorenz S, Mauriz JL, Heise M, Galle PR, González-Gallego J, Strand S.

Br J Cancer. 2013 Feb 5;108(2):442-9. doi: 10.1038/bjc.2012.563. Epub 2012 Dec 20.


FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells.

Liu H, Yin J, Wang C, Gu Y, Deng M, He Z.

Anticancer Drugs. 2014 Sep;25(8):898-907. doi: 10.1097/CAD.0000000000000117.


FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells.

Shukla S, Rizvi F, Raisuddin S, Kakkar P.

Free Radic Biol Med. 2014 Nov;76:185-99. doi: 10.1016/j.freeradbiomed.2014.07.039. Epub 2014 Aug 13.


Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M.

Cancer Res. 2010 Mar 15;70(6):2424-34. doi: 10.1158/0008-5472.CAN-09-0878. Epub 2010 Mar 9.


FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis.

Wang J, Liu S, Yin Y, Li M, Wang B, Yang L, Jiang Y.

Apoptosis. 2015 Mar;20(3):399-409. doi: 10.1007/s10495-014-1071-3.


The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms.

Paraiso KH, Haarberg HE, Wood E, Rebecca VW, Chen YA, Xiang Y, Ribas A, Lo RS, Weber JS, Sondak VK, John JK, Sarnaik AA, Koomen JM, Smalley KS.

Clin Cancer Res. 2012 May 1;18(9):2502-14. doi: 10.1158/1078-0432.CCR-11-2612. Epub 2012 Feb 20.


Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.

Guan H, Song L, Cai J, Huang Y, Wu J, Yuan J, Li J, Li M.

PLoS One. 2011;6(5):e19946. doi: 10.1371/journal.pone.0019946. Epub 2011 May 18.


PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.

Luo H, Yang Y, Duan J, Wu P, Jiang Q, Xu C.

Cell Death Dis. 2013 Feb 7;4:e481. doi: 10.1038/cddis.2013.3.

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