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TRPA1 is a component of the nociceptive response to CO2.

Wang YY, Chang RB, Liman ER.

J Neurosci. 2010 Sep 29;30(39):12958-63. doi: 10.1523/JNEUROSCI.2715-10.2010.


A TRPA1-dependent mechanism for the pungent sensation of weak acids.

Wang YY, Chang RB, Allgood SD, Silver WL, Liman ER.

J Gen Physiol. 2011 Jun;137(6):493-505. doi: 10.1085/jgp.201110615.


Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R.

J Clin Invest. 2008 Jul;118(7):2574-82. doi: 10.1172/JCI34886.


TRPA1 and TRPV4 activation in human odontoblasts stimulates ATP release.

Egbuniwe O, Grover S, Duggal AK, Mavroudis A, Yazdi M, Renton T, Di Silvio L, Grant AD.

J Dent Res. 2014 Sep;93(9):911-7. doi: 10.1177/0022034514544507.


Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.

Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A.

Neuron. 2004 Mar 25;41(6):849-57.


Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.

Raisinghani M, Zhong L, Jeffry JA, Bishnoi M, Pabbidi RM, Pimentel F, Cao DS, Evans MS, Premkumar LS.

Am J Physiol Cell Physiol. 2011 Sep;301(3):C587-600. doi: 10.1152/ajpcell.00465.2010.


Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.

Cruz-Orengo L, Dhaka A, Heuermann RJ, Young TJ, Montana MC, Cavanaugh EJ, Kim D, Story GM.

Mol Pain. 2008 Jul 31;4:30. doi: 10.1186/1744-8069-4-30.


Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing.

Nagata K, Duggan A, Kumar G, García-Añoveros J.

J Neurosci. 2005 Apr 20;25(16):4052-61.


Physiological, pharmacological and behavioral evidence for a TRPA1 channel that can elicit defensive responses in the medicinal leech.

Summers T, Wang Y, Hanten B, Burrell BD.

J Exp Biol. 2015 Oct;218(Pt 19):3023-31. doi: 10.1242/jeb.120600.


Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels.

Taylor-Clark TE, Undem BJ.

J Physiol. 2010 Feb 1;588(Pt 3):423-33. doi: 10.1113/jphysiol.2009.183301.


Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.

Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M.

Pflugers Arch. 2012 Apr;463(4):549-59. doi: 10.1007/s00424-011-1069-4.


The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

Wang YY, Chang RB, Waters HN, McKemy DD, Liman ER.

J Biol Chem. 2008 Nov 21;283(47):32691-703. doi: 10.1074/jbc.M803568200.


TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons.

Barabas ME, Kossyreva EA, Stucky CL.

PLoS One. 2012;7(10):e47988. doi: 10.1371/journal.pone.0047988.


Zinc activates damage-sensing TRPA1 ion channels.

Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A.

Nat Chem Biol. 2009 Mar;5(3):183-90. doi: 10.1038/nchembio.146.


Preferential activation of the vagal nodose nociceptive subtype by TRPA1 agonists in the guinea pig esophagus.

Brozmanova M, Ru F, Surdenikova L, Mazurova L, Taylor-Clark T, Kollarik M.

Neurogastroenterol Motil. 2011 Oct;23(10):e437-45. doi: 10.1111/j.1365-2982.2011.01768.x.


Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

Taylor-Clark TE, Ghatta S, Bettner W, Undem BJ.

Mol Pharmacol. 2009 Apr;75(4):820-9. doi: 10.1124/mol.108.054445.


Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.

Koo JY, Jang Y, Cho H, Lee CH, Jang KH, Chang YH, Shin J, Oh U.

Eur J Neurosci. 2007 Sep;26(5):1139-47.


Miogadial and miogatrial with alpha,beta-unsaturated 1,4-dialdehyde moieties--novel and potent TRPA1 agonists.

Iwasaki Y, Tanabe M, Kayama Y, Abe M, Kashio M, Koizumi K, Okumura Y, Morimitsu Y, Tominaga M, Ozawa Y, Watanabe T.

Life Sci. 2009 Jul 3;85(1-2):60-9. doi: 10.1016/j.lfs.2009.04.017.


Emergence of functional sensory subtypes as defined by transient receptor potential channel expression.

Hjerling-Leffler J, Alqatari M, Ernfors P, Koltzenburg M.

J Neurosci. 2007 Mar 7;27(10):2435-43.

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