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Items: 1 to 20 of 112

1.

Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy.

Sims K, Haynes CA, Kelly S, Allegood JC, Wang E, Momin A, Leipelt M, Reichart D, Glass CK, Sullards MC, Merrill AH Jr.

J Biol Chem. 2010 Dec 3;285(49):38568-79. doi: 10.1074/jbc.M110.170621. Epub 2010 Sep 27.

2.

Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2.

Chang ZQ, Lee SY, Kim HJ, Kim JR, Kim SJ, Hong IK, Oh BC, Choi CS, Goldberg IJ, Park TS.

Prostaglandins Other Lipid Mediat. 2011 Feb;94(1-2):44-52. doi: 10.1016/j.prostaglandins.2010.12.003. Epub 2010 Dec 15.

3.

Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae.

Yamagata M, Obara K, Kihara A.

Biochem Biophys Res Commun. 2011 Jul 15;410(4):786-91. doi: 10.1016/j.bbrc.2011.06.061. Epub 2011 Jun 14.

PMID:
21703229
4.

Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction.

Hamada Y, Nagasaki H, Fujiya A, Seino Y, Shang QL, Suzuki T, Hashimoto H, Oiso Y.

J Nutr Biochem. 2014 Dec;25(12):1309-16. doi: 10.1016/j.jnutbio.2014.07.008. Epub 2014 Sep 19.

PMID:
25283329
5.
6.

Autophagy regulates sphingolipid levels in the liver.

Alexaki A, Gupta SD, Majumder S, Kono M, Tuymetova G, Harmon JM, Dunn TM, Proia RL.

J Lipid Res. 2014 Dec;55(12):2521-31. doi: 10.1194/jlr.M051862. Epub 2014 Oct 20.

7.

Toll-like receptor 4 is a sensor for autophagy associated with innate immunity.

Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT.

Immunity. 2007 Jul;27(1):135-44. Epub 2007 Jul 19.

8.

A mouse macrophage lipidome.

Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S.

J Biol Chem. 2010 Dec 17;285(51):39976-85. doi: 10.1074/jbc.M110.182915. Epub 2010 Oct 5.

9.

Morphine potentiates LPS-induced autophagy initiation but inhibits autophagosomal maturation through distinct TLR4-dependent and independent pathways.

Wan J, Ma J, Anand V, Ramakrishnan S, Roy S.

Acta Physiol (Oxf). 2015 Jun;214(2):189-99. doi: 10.1111/apha.12506. Epub 2015 Apr 21.

10.

Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei.

Fridberg A, Olson CL, Nakayasu ES, Tyler KM, Almeida IC, Engman DM.

J Cell Sci. 2008 Feb 15;121(Pt 4):522-35. doi: 10.1242/jcs.016741. Epub 2008 Jan 29.

11.

TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.

Shi CS, Kehrl JH.

Sci Signal. 2010 May 25;3(123):ra42. doi: 10.1126/scisignal.2000751.

12.

Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells.

Kiefer K, Carreras-Sureda A, García-López R, Rubio-Moscardó F, Casas J, Fabriàs G, Vicente R.

J Biol Chem. 2015 Jan 30;290(5):2822-30. doi: 10.1074/jbc.M114.595116. Epub 2014 Dec 17.

13.

Characterization of heme as activator of Toll-like receptor 4.

Figueiredo RT, Fernandez PL, Mourao-Sa DS, Porto BN, Dutra FF, Alves LS, Oliveira MF, Oliveira PL, Graça-Souza AV, Bozza MT.

J Biol Chem. 2007 Jul 13;282(28):20221-9. Epub 2007 May 14.

14.

Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.

Russo SB, Tidhar R, Futerman AH, Cowart LA.

J Biol Chem. 2013 May 10;288(19):13397-409. doi: 10.1074/jbc.M112.428185. Epub 2013 Mar 25.

15.

Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages.

Schilling JD, Machkovech HM, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE.

J Biol Chem. 2013 Feb 1;288(5):2923-32. doi: 10.1074/jbc.M112.419978. Epub 2012 Dec 18.

16.

Involvement of a membrane potassium channel in heparan sulphate-induced activation of macrophages.

Ren JD, Fan L, Tian FZ, Fan KH, Yu BT, Jin WH, Tan YH, Cheng L.

Immunology. 2014 Mar;141(3):345-52. doi: 10.1111/imm.12193.

17.

Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways.

Doyle A, Zhang G, Abdel Fattah EA, Eissa NT, Li YP.

FASEB J. 2011 Jan;25(1):99-110. doi: 10.1096/fj.10-164152. Epub 2010 Sep 8.

18.

Depletion of sphingolipids facilitates endosome to Golgi transport of ricin.

Grimmer S, Spilsberg B, Hanada K, Sandvig K.

Traffic. 2006 Sep;7(9):1243-53.

19.

Activation of Toll-like receptors by Burkholderia pseudomallei.

West TE, Ernst RK, Jansson-Hutson MJ, Skerrett SJ.

BMC Immunol. 2008 Aug 8;9:46. doi: 10.1186/1471-2172-9-46.

20.

SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages.

Prêle CM, Woodward EA, Bisley J, Keith-Magee A, Nicholson SE, Hart PH.

J Immunol. 2008 Dec 1;181(11):8018-26.

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