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Items: 1 to 20 of 83

1.

Discovery of 2-aminoimidazopyridine adenosine A(2A) receptor antagonists.

McGuinness BF, Cole AG, Dong G, Brescia MR, Shao Y, Henderson I, Rokosz LL, Stauffer TM, Mannava N, Kimble EF, Hicks C, White N, Wines PG, Quadros E.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6845-9. doi: 10.1016/j.bmcl.2010.08.064. Epub 2010 Aug 19.

PMID:
20869242
2.

Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.

Michielan L, Bolcato C, Federico S, Cacciari B, Bacilieri M, Klotz KN, Kachler S, Pastorin G, Cardin R, Sperduti A, Spalluto G, Moro S.

Bioorg Med Chem. 2009 Jul 15;17(14):5259-74. doi: 10.1016/j.bmc.2009.05.038. Epub 2009 May 21.

PMID:
19501513
3.

The discovery and synthesis of novel adenosine receptor (A(2A)) antagonists.

Matasi JJ, Caldwell JP, Hao J, Neustadt B, Arik L, Foster CJ, Lachowicz J, Tulshian DB.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1333-6.

PMID:
15713381
4.

3D pharmacophore based virtual screening of A 2A adenosine receptor antagonists.

Wei J, Qu W, Ye Y, Gao Q.

Protein Pept Lett. 2010 Mar;17(3):332-9.

PMID:
20236086
5.

Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2H-thiazolo [4,5-d] pyrimidine derivatives as adenosine A2A receptor antagonists.

Luthra PM, Mishra CB, Jha PK, Barodia SK.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1214-8. doi: 10.1016/j.bmcl.2009.11.133. Epub 2009 Dec 4.

PMID:
20018509
6.

Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.

Weiss SM, Benwell K, Cliffe IA, Gillespie RJ, Knight AR, Lerpiniere J, Misra A, Pratt RM, Revell D, Upton R, Dourish CT.

Neurology. 2003 Dec 9;61(11 Suppl 6):S101-6.

PMID:
14663021
7.

2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.

Moorjani M, Luo Z, Lin E, Vong BG, Chen Y, Zhang X, Rueter JK, Gross RS, Lanier MC, Tellew JE, Williams JP, Lechner SM, Malany S, Santos M, Crespo MI, Díaz JL, Saunders J, Slee DH.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5402-5. doi: 10.1016/j.bmcl.2008.09.048. Epub 2008 Sep 14.

PMID:
18835161
8.

Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine A2A receptor.

Michielan L, Bacilieri M, Schiesaro A, Bolcato C, Pastorin G, Spalluto G, Cacciari B, Klotz KN, Kaseda C, Moro S.

J Chem Inf Model. 2008 Feb;48(2):350-63. doi: 10.1021/ci700300w. Epub 2008 Jan 24.

PMID:
18215030
9.

6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists.

Kiselgof E, Tulshian DB, Arik L, Zhang H, Fawzi A.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2119-22.

PMID:
15808481
10.

Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.

Baraldi PG, Fruttarolo F, Tabrizi MA, Preti D, Romagnoli R, El-Kashef H, Moorman A, Varani K, Gessi S, Merighi S, Borea PA.

J Med Chem. 2003 Mar 27;46(7):1229-41.

PMID:
12646033
11.

Recent developments in the field of A2A and A3 adenosine receptor antagonists.

Baraldi PG, Tabrizi MA, Bovero A, Avitabile B, Preti D, Fruttarolo F, Romagnoli R, Varani K, Borea PA.

Eur J Med Chem. 2003 Apr;38(4):367-82.

PMID:
12750024
12.

Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists.

Shah U, Boyle CD, Chackalamannil S, Neustadt BR, Lindo N, Greenlee WJ, Foster C, Arik L, Zhai Y, Ng K, Wang S, Monopoli A, Lachowicz JE.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4199-203. doi: 10.1016/j.bmcl.2008.05.074. Epub 2008 May 22.

PMID:
18562199
13.

2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.

Chang LC, Spanjersberg RF, von Frijtag Drabbe Künzel JK, Mulder-Krieger T, van den Hout G, Beukers MW, Brussee J, Ijzerman AP.

J Med Chem. 2004 Dec 16;47(26):6529-40.

PMID:
15588088
14.
15.

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.

Gillespie RJ, Adams DR, Bebbington D, Benwell K, Cliffe IA, Dawson CE, Dourish CT, Fletcher A, Gaur S, Giles PR, Jordan AM, Knight AR, Knutsen LJ, Lawrence A, Lerpiniere J, Misra A, Porter RH, Pratt RM, Shepherd R, Upton R, Ward SE, Weiss SM, Williamson DS.

Bioorg Med Chem Lett. 2008 May 1;18(9):2916-9. doi: 10.1016/j.bmcl.2008.03.075. Epub 2008 Mar 30.

PMID:
18406614
16.

2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships.

Slee DH, Moorjani M, Zhang X, Lin E, Lanier MC, Chen Y, Rueter JK, Lechner SM, Markison S, Malany S, Joswig T, Santos M, Gross RS, Williams JP, Castro-Palomino JC, Crespo MI, Prat M, Gual S, Díaz JL, Jalali K, Sai Y, Zuo Z, Yang C, Wen J, O'Brien Z, Petroski R, Saunders J.

J Med Chem. 2008 Mar 27;51(6):1730-9. doi: 10.1021/jm701187w. Epub 2008 Feb 29.

PMID:
18307293
17.

Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists.

Mishra CB, Barodia SK, Prakash A, Senthil Kumar JB, Luthra PM.

Bioorg Med Chem. 2010 Apr 1;18(7):2491-500. doi: 10.1016/j.bmc.2010.02.048. Epub 2010 Mar 1.

PMID:
20303771
18.
19.

Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.

Peng H, Kumaravel G, Yao G, Sha L, Wang J, Van Vlijmen H, Bohnert T, Huang C, Vu CB, Ensinger CL, Chang H, Engber TM, Whalley ET, Petter RC.

J Med Chem. 2004 Dec 2;47(25):6218-29.

PMID:
15566292
20.

Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.

Jörg M, Shonberg J, Mak FS, Miller ND, Yuriev E, Scammells PJ, Capuano B.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3427-33. doi: 10.1016/j.bmcl.2013.03.070. Epub 2013 Apr 2.

PMID:
23602401

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