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Items: 1 to 20 of 116

1.

Genetic variation in insulin/IGF-1 signaling pathways and longevity.

Ziv E, Hu D.

Ageing Res Rev. 2011 Apr;10(2):201-4. doi: 10.1016/j.arr.2010.09.002. Epub 2010 Sep 22. Review.

PMID:
20868776
2.

Genetic variation and human longevity.

Soerensen M.

Dan Med J. 2012 May;59(5):B4454.

PMID:
22549493
3.

Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.

Morris BJ, Donlon TA, He Q, Grove JS, Masaki KH, Elliott A, Willcox DC, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):270-3. doi: 10.1093/gerona/glt082. Epub 2013 Jun 14.

4.
5.

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E; Study of Osteoporotic Fractures.

Aging Cell. 2009 Aug;8(4):460-72. doi: 10.1111/j.1474-9726.2009.00493.x. Epub 2009 May 31.

6.

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.

7.

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.

Lin K, Hsin H, Libina N, Kenyon C.

Nat Genet. 2001 Jun;28(2):139-45.

PMID:
11381260
8.

The search for DAF-16/FOXO transcriptional targets: approaches and discoveries.

Murphy CT.

Exp Gerontol. 2006 Oct;41(10):910-21. Epub 2006 Aug 24. Review.

PMID:
16934425
9.

A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.

Oláhová M, Veal EA.

Aging Cell. 2015 Aug;14(4):558-68. doi: 10.1111/acel.12321. Epub 2015 Mar 23.

10.

Worming pathways to and from DAF-16/FOXO.

Mukhopadhyay A, Oh SW, Tissenbaum HA.

Exp Gerontol. 2006 Oct;41(10):928-34. Epub 2006 Jul 12. Review.

PMID:
16839734
11.

Longevity genes: from primitive organisms to humans.

Warner HR.

Mech Ageing Dev. 2005 Feb;126(2):235-42. Review.

PMID:
15621202
12.

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.

Bonafè M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, Mugianesi E, Centurelli M, Franceschi C, Paolisso G.

J Clin Endocrinol Metab. 2003 Jul;88(7):3299-304.

PMID:
12843179
13.

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.

Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C.

Nature. 2003 Jul 17;424(6946):277-83. Epub 2003 Jun 29.

PMID:
12845331
14.

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.

Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Böhringer S, van den Akker EB, de Craen AJ, Rivadeneira F, Uitterlinden AG, Westendorp RG, Goeman JJ, Slagboom PE, Houwing-Duistermaat JJ, Beekman M.

Age (Dordr). 2013 Feb;35(1):235-49. doi: 10.1007/s11357-011-9340-3. Epub 2011 Nov 24.

15.

Role of the IGF/insulin system in longevity.

Mari D.

Minerva Endocrinol. 2011 Sep;36(3):181-5.

PMID:
22019749
16.

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination.

Papaconstantinou J.

Mol Cell Endocrinol. 2009 Feb 5;299(1):89-100. doi: 10.1016/j.mce.2008.11.025. Epub 2008 Dec 3. Review.

17.

The paradox of the insulin/IGF-1 signaling pathway in longevity.

Rincon M, Muzumdar R, Atzmon G, Barzilai N.

Mech Ageing Dev. 2004 Jun;125(6):397-403. Review.

PMID:
15272501
18.

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.

Anisimov VN, Bartke A.

Crit Rev Oncol Hematol. 2013 Sep;87(3):201-23. doi: 10.1016/j.critrevonc.2013.01.005. Epub 2013 Feb 21. Review.

19.

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Jacobsen R, Suchiman HE, de Craen AJ, Westendorp RG, Schreiber S, Stevnsner T, Bohr VA, Slagboom PE, Nebel A, Vaupel JW, Christensen K, McGue M, Christiansen L.

Exp Gerontol. 2012 May;47(5):379-87. doi: 10.1016/j.exger.2012.02.010. Epub 2012 Mar 3.

20.

FOXO3 and related transcription factors in development, aging, and exceptional longevity.

Kahn AJ.

J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):421-5. doi: 10.1093/gerona/glu044. Epub 2014 Apr 18.

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