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Items: 1 to 20 of 106


Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway.

Varma H, Yamamoto A, Sarantos MR, Hughes RE, Stockwell BR.

J Biol Chem. 2010 Nov 26;285(48):37445-57. doi: 10.1074/jbc.M110.125542.


The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.

Kakiashvili E, Dan Q, Vandermeer M, Zhang Y, Waheed F, Pham M, Szászi K.

J Biol Chem. 2011 Mar 18;286(11):9268-79. doi: 10.1074/jbc.M110.179903.


Role of guanine nucleotide exchange factor-H1 in complement-mediated RhoA activation in glomerular epithelial cells.

Mouawad F, Aoudjit L, Jiang R, Szaszi K, Takano T.

J Biol Chem. 2014 Feb 14;289(7):4206-18. doi: 10.1074/jbc.M113.506816.


GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.

Chang YC, Nalbant P, Birkenfeld J, Chang ZF, Bokoch GM.

Mol Biol Cell. 2008 May;19(5):2147-53. doi: 10.1091/mbc.E07-12-1269.


Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

Nalbant P, Chang YC, Birkenfeld J, Chang ZF, Bokoch GM.

Mol Biol Cell. 2009 Sep;20(18):4070-82. doi: 10.1091/mbc.E09-01-0041.


Microtubules regulate GEF-H1 in response to extracellular matrix stiffness.

Heck JN, Ponik SM, Garcia-Mendoza MG, Pehlke CA, Inman DR, Eliceiri KW, Keely PJ.

Mol Biol Cell. 2012 Jul;23(13):2583-92. doi: 10.1091/mbc.E11-10-0876.


Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis.

Chang YC, Lee HH, Chen YJ, Bokoch GM, Chang ZF.

Cell Death Differ. 2006 Dec;13(12):2023-32.


Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.

Waheed F, Dan Q, Amoozadeh Y, Zhang Y, Tanimura S, Speight P, Kapus A, Szászi K.

Mol Biol Cell. 2013 Apr;24(7):1068-82. doi: 10.1091/mbc.E12-09-0661.


GEF-H1/RhoA signalling pathway mediates lipopolysaccharide-induced intercellular adhesion molecular-1 expression in endothelial cells via activation of p38 and NF-κB.

Guo F, Zhou Z, Dou Y, Tang J, Gao C, Huan J.

Cytokine. 2012 Mar;57(3):417-28. doi: 10.1016/j.cyto.2011.12.009.


CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.

Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, Thompson LM.

Mol Cell Neurosci. 2008 Sep;39(1):8-20. doi: 10.1016/j.mcn.2008.04.007.


Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.

von Thun A, Preisinger C, Rath O, Schwarz JP, Ward C, Monsefi N, Rodríguez J, Garcia-Munoz A, Birtwistle M, Bienvenut W, Anderson KI, Kolch W, von Kriegsheim A.

Mol Cell Biol. 2013 Nov;33(22):4526-37. doi: 10.1128/MCB.00585-13.


Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27.

Yu L, Quinn DA, Garg HG, Hales CA.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):524-30. doi: 10.1165/rcmb.2010-0145OC.


Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules.

van Horck FP, Ahmadian MR, Haeusler LC, Moolenaar WH, Kranenburg O.

J Biol Chem. 2001 Feb 16;276(7):4948-56.


Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton.

Krendel M, Zenke FT, Bokoch GM.

Nat Cell Biol. 2002 Apr;4(4):294-301.


Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.

Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A.

EMBO J. 2004 Sep 1;23(17):3570-82.


GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.

Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM.

Dev Cell. 2007 May;12(5):699-712. Erratum in: Dev Cell. 2007 Jun;12(6):1007.


The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration.

Tsapara A, Luthert P, Greenwood J, Hill CS, Matter K, Balda MS.

Mol Biol Cell. 2010 Mar 15;21(6):860-70. doi: 10.1091/mbc.E09-07-0567.


IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.

Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK.

Hum Mol Genet. 2012 Jan 1;21(1):101-14. doi: 10.1093/hmg/ddr445.


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