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Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor.

Dafni H, Larson PE, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM.

Cancer Res. 2010 Oct 1;70(19):7400-10. doi: 10.1158/0008-5472.CAN-10-0883. Epub 2010 Sep 21.


Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer.

Kim SJ, Uehara H, Yazici S, Busby JE, Nakamura T, He J, Maya M, Logothetis C, Mathew P, Wang X, Do KA, Fan D, Fidler IJ.

J Natl Cancer Inst. 2006 Jun 7;98(11):783-93.


Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases.

Uehara H, Kim SJ, Karashima T, Shepherd DL, Fan D, Tsan R, Killion JJ, Logothetis C, Mathew P, Fidler IJ.

J Natl Cancer Inst. 2003 Mar 19;95(6):458-70.


Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice.

Lev DC, Kim SJ, Onn A, Stone V, Nam DH, Yazici S, Fidler IJ, Price JE.

Clin Cancer Res. 2005 Jan 1;11(1):306-14.


Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.

Dutta P, Le A, Vander Jagt DL, Tsukamoto T, Martinez GV, Dang CV, Gillies RJ.

Cancer Res. 2013 Jul 15;73(14):4190-5. doi: 10.1158/0008-5472.CAN-13-0465. Epub 2013 May 30.


Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells.

Dong Y, Jia L, Wang X, Tan X, Xu J, Deng Z, Jiang T, Rainov NG, Li B, Ren H.

Int J Oncol. 2011 Feb;38(2):555-69. doi: 10.3892/ijo.2010.861. Epub 2010 Dec 6.


Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.

Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson SJ, Vigneron DB, Kurhanewicz J.

Cancer Res. 2008 Oct 15;68(20):8607-15. doi: 10.1158/0008-5472.CAN-08-0749.


Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

Witney TH, Brindle KM.

Biochem Soc Trans. 2010 Oct;38(5):1220-4. doi: 10.1042/BST0381220.


Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.

Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM.

Cancer Res. 2010 Feb 15;70(4):1296-305. doi: 10.1158/0008-5472.CAN-09-2251. Epub 2010 Feb 9.


Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function.

Semela D, Das A, Langer D, Kang N, Leof E, Shah V.

Gastroenterology. 2008 Aug;135(2):671-9. doi: 10.1053/j.gastro.2008.04.010. Epub 2008 Apr 16.


Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer.

Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Onoyama M, Ohnishi M, Ohara E, Higashi Y, Tanaka S, Yasui W, Chayama K.

Int J Cancer. 2013 Feb 15;132(4):813-23. doi: 10.1002/ijc.27735. Epub 2012 Aug 6.


Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

Pietras K, Ostman A, Sjöquist M, Buchdunger E, Reed RK, Heldin CH, Rubin K.

Cancer Res. 2001 Apr 1;61(7):2929-34.


Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.

Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM.

Neuroimage. 2012 Jan 2;59(1):193-201. doi: 10.1016/j.neuroimage.2011.07.034. Epub 2011 Jul 23.


Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI.

Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB.

Magn Reson Med. 2010 Mar;63(3):582-91. doi: 10.1002/mrm.22264.


Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.

George D.

Adv Exp Med Biol. 2003;532:141-51. Review.


13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.

Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A.

Cell Metab. 2011 Jul 6;14(1):131-42. doi: 10.1016/j.cmet.2011.04.012.


Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate.

Kennedy BW, Kettunen MI, Hu DE, Brindle KM.

J Am Chem Soc. 2012 Mar 14;134(10):4969-77. doi: 10.1021/ja300222e. Epub 2012 Mar 1.

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