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Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.

Painter HJ, Morrisey JM, Vaidya AB.

Antimicrob Agents Chemother. 2010 Dec;54(12):5281-7. doi: 10.1128/AAC.00937-10. Epub 2010 Sep 20.


Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Painter HJ, Morrisey JM, Mather MW, Vaidya AB.

Nature. 2007 Mar 1;446(7131):88-91.


The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

Ehrhardt K, Davioud-Charvet E, Ke H, Vaidya AB, Lanzer M, Deponte M.

Antimicrob Agents Chemother. 2013 May;57(5):2114-20. doi: 10.1128/AAC.02248-12. Epub 2013 Feb 25.


Emergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reports.

Cottrell G, Musset L, Hubert V, Le Bras J, Clain J; Atovaquone-Proguanil Treatment Failure Study Group.

Antimicrob Agents Chemother. 2014 Aug;58(8):4504-14. doi: 10.1128/AAC.02550-13. Epub 2014 May 27.


Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, Vaidya AB.

Eukaryot Cell. 2011 Aug;10(8):1053-61. doi: 10.1128/EC.05049-11. Epub 2011 Jun 17.


Atovaquone and proguanil hydrochloride: a review of nonclinical studies.

Pudney M, Gutteridge W, Zeman A, Dickins M, Woolley JL.

J Travel Med. 1999 May;6 Suppl 1:S8-12. Review.


Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages.

Moneriz C, Marín-García P, García-Granados A, Bautista JM, Diez A, Puyet A.

Malar J. 2011 Apr 10;10:82. doi: 10.1186/1475-2875-10-82.


Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor.

Guler JL, White J 3rd, Phillips MA, Rathod PK.

Antimicrob Agents Chemother. 2015 Jan;59(1):686-9. doi: 10.1128/AAC.02347-14. Epub 2014 Oct 20.


Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.

Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, Pacorel B, Lawrenson AS, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Stocks PA, Nixon GL, Chadwick J, Hemingway J, Delves MJ, Sinden RE, Zeeman AM, Kocken CH, Berry NG, O'Neill PM, Ward SA.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8298-303. doi: 10.1073/pnas.1205651109. Epub 2012 May 7.


A drug-selected Plasmodium falciparum lacking the need for conventional electron transport.

Smilkstein MJ, Forquer I, Kanazawa A, Kelly JX, Winter RW, Hinrichs DJ, Kramer DM, Riscoe MK.

Mol Biochem Parasitol. 2008 May;159(1):64-8. doi: 10.1016/j.molbiopara.2008.01.002. Epub 2008 Jan 19.


The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase.

Ittarat I, Asawamahasakda W, Meshnick SR.

Exp Parasitol. 1994 Aug;79(1):50-6.


Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis.

Nyakeriga AM, Perlmann H, Hagstedt M, Berzins K, Troye-Blomberg M, Zhivotovsky B, Perlmann P, Grandien A.

Microbes Infect. 2006 May;8(6):1560-8. Epub 2006 Apr 18.


Transcript level responses of Plasmodium falciparum to antimycin A.

Tarr SJ, Nisbet RE, Howe CJ.

Protist. 2012 Sep;163(5):755-66. doi: 10.1016/j.protis.2012.01.003. Epub 2012 Apr 12.


Radicicol confers mid-schizont arrest by inhibiting mitochondrial replication in Plasmodium falciparum.

Chalapareddy S, Bhattacharyya MK, Mishra S, Bhattacharyya S.

Antimicrob Agents Chemother. 2014 Aug;58(8):4341-52. doi: 10.1128/AAC.02519-13. Epub 2014 May 19.


[Mechanism of action of antimalarials. Value of combined atovaquone/proguanil].

Touze JE, Fourcade L, Pradines B, Hovette P, Paule P, Heno P.

Med Trop (Mars). 2002;62(3):219-24. Review. French.


Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum.

Das S, Bhatanagar S, Morrisey JM, Daly TM, Burns JM Jr, Coppens I, Vaidya AB.

PLoS Pathog. 2016 May 26;12(5):e1005647. doi: 10.1371/journal.ppat.1005647. eCollection 2016 May.


Effects of dual combinations of antifolates with atovaquone or dapsone on nucleotide levels in Plasmodium falciparum.

Yeo AE, Seymour KK, Rieckmann KH, Christopherson RI.

Biochem Pharmacol. 1997 Apr 4;53(7):943-50.


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