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PERK in beta cell biology and insulin biogenesis.

Cavener DR, Gupta S, McGrath BC.

Trends Endocrinol Metab. 2010 Dec;21(12):714-21. doi: 10.1016/j.tem.2010.08.005. Epub 2010 Sep 17. Review.


Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR.

PLoS One. 2014 Jun 10;9(6):e99684. doi: 10.1371/journal.pone.0099684. eCollection 2014.


PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

Gupta S, McGrath B, Cavener DR.

Diabetes. 2010 Aug;59(8):1937-47. doi: 10.2337/db09-1064. Epub 2010 Jun 8.


Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

Feng D, Wei J, Gupta S, McGrath BC, Cavener DR.

BMC Cell Biol. 2009 Sep 4;10:61. doi: 10.1186/1471-2121-10-61.


Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR.

J Biol Chem. 2013 Nov 22;288(47):33824-36. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10.


Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

Harding HP, Zyryanova AF, Ron D.

J Biol Chem. 2012 Dec 28;287(53):44338-44. doi: 10.1074/jbc.M112.428987. Epub 2012 Nov 12.


Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.

Yamani L, Li B, Larose L.

Cell Signal. 2015 Dec;27(12):2555-67. doi: 10.1016/j.cellsig.2015.09.016. Epub 2015 Oct 3.


The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.

Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K.

Cell Struct Funct. 2013;38(2):183-95. Epub 2013 Jun 28. Erratum in: Cell Struct Funct. 2014;39(1):21. Cell Struct Funct. 2013;38(2):227.


PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.

Gupta S, McGrath B, Cavener DR.

PLoS One. 2009 Nov 24;4(11):e8008. doi: 10.1371/journal.pone.0008008.


PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.

Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA.

Mol Cell Biol. 2012 Dec;32(24):5129-39. doi: 10.1128/MCB.01009-12. Epub 2012 Oct 15.


COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.

Fang J, Liu M, Zhang X, Sakamoto T, Taatjes DJ, Jena BP, Sun F, Woods J, Bryson T, Kowluru A, Zhang K, Chen X.

Mol Endocrinol. 2015 Aug;29(8):1156-69. doi: 10.1210/me.2015-1012. Epub 2015 Jun 17.


Interaction of Nck1 and PERK phosphorylated at Y⁵⁶¹ negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content.

Yamani L, Latreille M, Larose L.

Mol Biol Cell. 2014 Mar;25(5):702-11. doi: 10.1091/mbc.E13-09-0511. Epub 2013 Dec 26.


The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR.

J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14.


The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells.

Kaufman RJ, Back SH, Song B, Han J, Hassler J.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:99-107. doi: 10.1111/j.1463-1326.2010.01281.x. Review.


PERK mediates cell-cycle exit during the mammalian unfolded protein response.

Brewer JW, Diehl JA.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12625-30.


The endoplasmic reticulum stress response in the pancreatic β-cell.

Volchuk A, Ron D.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:48-57. doi: 10.1111/j.1463-1326.2010.01271.x. Review.


Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

Diabetes. 2008 Nov;57(11):3034-44. doi: 10.2337/db07-1802. Epub 2008 Jun 30.


Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.

Hartley T, Siva M, Lai E, Teodoro T, Zhang L, Volchuk A.

BMC Cell Biol. 2010 Jul 26;11:59. doi: 10.1186/1471-2121-11-59.

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