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Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI.

Gibert M, Monier MN, Ruez R, Hale ML, Stiles BG, Benmerah A, Johannes L, Lamaze C, Popoff MR.

Cell Microbiol. 2011 Jan;13(1):154-70. doi: 10.1111/j.1462-5822.2010.01527.x. Epub 2010 Oct 19.


Differential requirement for the translocation of clostridial binary toxins: iota toxin requires a membrane potential gradient.

Gibert M, Marvaud JC, Pereira Y, Hale ML, Stiles BG, Boquet P, Lamaze C, Popoff MR.

FEBS Lett. 2007 Apr 3;581(7):1287-96. Epub 2007 Feb 28.


Clostridium botulinum C2 toxin is internalized by clathrin- and Rho-dependent mechanisms.

Pust S, Barth H, Sandvig K.

Cell Microbiol. 2010 Dec;12(12):1809-20. doi: 10.1111/j.1462-5822.2010.01512.x.


Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins.

Ernst K, Langer S, Kaiser E, Osseforth C, Michaelis J, Popoff MR, Schwan C, Aktories K, Kahlert V, Malesevic M, Schiene-Fischer C, Barth H.

J Mol Biol. 2015 Mar 27;427(6 Pt A):1224-38. doi: 10.1016/j.jmb.2014.07.013. Epub 2014 Jul 21.


EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin.

Schnell L, Mittler AK, Sadi M, Popoff MR, Schwan C, Aktories K, Mattarei A, Azarnia Tehran D, Montecucco C, Barth H.

Toxins (Basel). 2016 Apr 1;8(4):101. doi: 10.3390/toxins8040101.


CD44 Promotes intoxication by the clostridial iota-family toxins.

Wigelsworth DJ, Ruthel G, Schnell L, Herrlich P, Blonder J, Veenstra TD, Carman RJ, Wilkins TD, Van Nhieu GT, Pauillac S, Gibert M, Sauvonnet N, Stiles BG, Popoff MR, Barth H.

PLoS One. 2012;7(12):e51356. doi: 10.1371/journal.pone.0051356. Epub 2012 Dec 7.


The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol.

Haug G, Leemhuis J, Tiemann D, Meyer DK, Aktories K, Barth H.

J Biol Chem. 2003 Aug 22;278(34):32266-74. Epub 2003 Jun 12.


The long-lived nature of clostridium perfringens iota toxin in mammalian cells induces delayed apoptosis.

Hilger H, Pust S, von Figura G, Kaiser E, Stiles BG, Popoff MR, Barth H.

Infect Immun. 2009 Dec;77(12):5593-601. doi: 10.1128/IAI.00710-09. Epub 2009 Oct 5.


Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex.

Genth H, Gerhard R, Maeda A, Amano M, Kaibuchi K, Aktories K, Just I.

J Biol Chem. 2003 Aug 1;278(31):28523-7. Epub 2003 May 15.


Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

Kaiser E, Kroll C, Ernst K, Schwan C, Popoff M, Fischer G, Buchner J, Aktories K, Barth H.

Infect Immun. 2011 Oct;79(10):3913-21. doi: 10.1128/IAI.05372-11. Epub 2011 Jul 18.


Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization.

Marvaud JC, Stiles BG, Chenal A, Gillet D, Gibert M, Smith LA, Popoff MR.

J Biol Chem. 2002 Nov 15;277(46):43659-66. Epub 2002 Sep 6.


FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells.

Kaiser E, Böhm N, Ernst K, Langer S, Schwan C, Aktories K, Popoff M, Fischer G, Barth H.

Cell Microbiol. 2012 Aug;14(8):1193-205. doi: 10.1111/j.1462-5822.2012.01788.x. Epub 2012 Apr 12.


[Analysis of synaptic neurotransmitter release mechanisms using bacterial toxins].

Doussau F, Humeau Y, Vitiello F, Popoff MR, Poulain B.

J Soc Biol. 1999;193(6):457-67. Review. French.


Pore-forming activity of clostridial binary toxins.

Knapp O, Benz R, Popoff MR.

Biochim Biophys Acta. 2016 Mar;1858(3):512-25. doi: 10.1016/j.bbamem.2015.08.006. Epub 2015 Aug 14. Review.


Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile.

Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H.

Infect Immun. 2001 Oct;69(10):6004-11.


Uptake of clostridium botulinum C3 exoenzyme into intact HT22 and J774A.1 cells.

Rohrbeck A, von Elsner L, Hagemann S, Just I.

Toxins (Basel). 2015 Feb 2;7(2):380-95. doi: 10.3390/toxins7020380.


Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway.

Lamaze C, Dujeancourt A, Baba T, Lo CG, Benmerah A, Dautry-Varsat A.

Mol Cell. 2001 Mar;7(3):661-71.


Clostridial binary toxins: iota and C2 family portraits.

Stiles BG, Wigelsworth DJ, Popoff MR, Barth H.

Front Cell Infect Microbiol. 2011 Dec 1;1:11. doi: 10.3389/fcimb.2011.00011. eCollection 2011. Review.

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