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Lunatic fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo.

Visan I, Yuan JS, Liu Y, Stanley P, Guidos CJ.

J Immunol. 2010 Oct 15;185(8):4609-17. doi: 10.4049/jimmunol.1002008. Epub 2010 Sep 15.


Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors.

Yuan JS, Tan JB, Visan I, Matei IR, Urbanellis P, Xu K, Danska JS, Egan SE, Guidos CJ.

Blood. 2011 Jan 27;117(4):1184-95. doi: 10.1182/blood-2010-07-296616. Epub 2010 Nov 19.


Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions.

Visan I, Yuan JS, Tan JB, Cretegny K, Guidos CJ.

Immunol Rev. 2006 Feb;209:76-94. Review.


Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches.

Visan I, Tan JB, Yuan JS, Harper JA, Koch U, Guidos CJ.

Nat Immunol. 2006 Jun;7(6):634-43. Epub 2006 May 14.


Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Zúñiga-Pflücker JC, Izon DJ.

Int Immunol. 2007 Dec;19(12):1421-30. Epub 2007 Nov 1.


Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.

Suliman S, Tan J, Xu K, Kousis PC, Kowalski PE, Chang G, Egan SE, Guidos C.

PLoS One. 2011;6(9):e24937. doi: 10.1371/journal.pone.0024937. Epub 2011 Sep 13.


Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.

Besseyrias V, Fiorini E, Strobl LJ, Zimber-Strobl U, Dumortier A, Koch U, Arcangeli ML, Ezine S, Macdonald HR, Radtke F.

J Exp Med. 2007 Feb 19;204(2):331-43. Epub 2007 Jan 29.


Synergy between the pre-T cell receptor and Notch: cementing the alphabeta lineage choice.

Guidos CJ.

J Exp Med. 2006 Oct 2;203(10):2233-7. Epub 2006 Sep 25. Review.


Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

Koch U, Fiorini E, Benedito R, Besseyrias V, Schuster-Gossler K, Pierres M, Manley NR, Duarte A, Macdonald HR, Radtke F.

J Exp Med. 2008 Oct 27;205(11):2515-23. doi: 10.1084/jem.20080829. Epub 2008 Sep 29.


Lunatic fringe controls T cell differentiation through modulating notch signaling.

Tsukumo S, Hirose K, Maekawa Y, Kishihara K, Yasutomo K.

J Immunol. 2006 Dec 15;177(12):8365-71.


Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition.

Huang EY, Gallegos AM, Richards SM, Lehar SM, Bevan MJ.

J Immunol. 2003 Sep 1;171(5):2296-304.


Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.

Song Y, Kumar V, Wei HX, Qiu J, Stanley P.

J Immunol. 2016 Jan 1;196(1):232-43. doi: 10.4049/jimmunol.1402421. Epub 2015 Nov 25.


The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

Maillard I, Tu L, Sambandam A, Yashiro-Ohtani Y, Millholland J, Keeshan K, Shestova O, Xu L, Bhandoola A, Pear WS.

J Exp Med. 2006 Oct 2;203(10):2239-45. Epub 2006 Sep 11.


Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus.

Hager-Theodorides AL, Rowbotham NJ, Outram SV, Dessens JT, Crompton T.

Eur J Immunol. 2007 Feb;37(2):487-500.


Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

Koch U, Lacombe TA, Holland D, Bowman JL, Cohen BL, Egan SE, Guidos CJ.

Immunity. 2001 Aug;15(2):225-36.


Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.

Haks MC, Pépin E, van den Brakel JH, Smeele SA, Belkowski SM, Kessels HW, Krimpenfort P, Kruisbeek AM.

J Exp Med. 2002 Jul 1;196(1):1-13.


Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes.

Keir ME, Latchman YE, Freeman GJ, Sharpe AH.

J Immunol. 2005 Dec 1;175(11):7372-9.


Requirement for Notch1 signals at sequential early stages of intrathymic T cell development.

Tan JB, Visan I, Yuan JS, Guidos CJ.

Nat Immunol. 2005 Jul;6(7):671-9. Epub 2005 Jun 12. Erratum in: Nat Immunol. 2005 Sep;6(9):954.


IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection.

Boudil A, Matei IR, Shih HY, Bogdanoski G, Yuan JS, Chang SG, Montpellier B, Kowalski PE, Voisin V, Bashir S, Bader GD, Krangel MS, Guidos CJ.

Nat Immunol. 2015 Apr;16(4):397-405. doi: 10.1038/ni.3122. Epub 2015 Mar 2.


Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation.

Ciofani M, Knowles GC, Wiest DL, von Boehmer H, Zúñiga-Pflücker JC.

Immunity. 2006 Jul;25(1):105-16. Epub 2006 Jun 29.

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