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Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.

Coffee B, Zhang F, Ceman S, Warren ST, Reines D.

Am J Hum Genet. 2002 Oct;71(4):923-32. Epub 2002 Sep 13.


CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons.

Zhou Y, Kumari D, Sciascia N, Usdin K.

Mol Autism. 2016 Oct 6;7:42. eCollection 2016.


SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.

Biacsi R, Kumari D, Usdin K.

PLoS Genet. 2008 Mar 7;4(3):e1000017. doi: 10.1371/journal.pgen.1000017.


Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.

Kumari D, Usdin K.

Hum Mol Genet. 2014 Dec 15;23(24):6575-83. doi: 10.1093/hmg/ddu378. Epub 2014 Jul 23.


Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments.

Tabolacci E, Pietrobono R, Moscato U, Oostra BA, Chiurazzi P, Neri G.

Eur J Hum Genet. 2005 May;13(5):641-8.


Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome.

Brasa S, Mueller A, Jacquemont S, Hahne F, Rozenberg I, Peters T, He Y, McCormack C, Gasparini F, Chibout SD, Grenet O, Moggs J, Gomez-Mancilla B, Terranova R.

Clin Epigenetics. 2016 Feb 5;8:15. doi: 10.1186/s13148-016-0181-x. eCollection 2016.


Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

Todd PK, Oh SY, Krans A, Pandey UB, Di Prospero NA, Min KT, Taylor JP, Paulson HL.

PLoS Genet. 2010 Dec 9;6(12):e1001240. doi: 10.1371/journal.pgen.1001240.


Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.

Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L, Loring JF, Haggarty SJ.

PLoS One. 2011;6(10):e26203. doi: 10.1371/journal.pone.0026203. Epub 2011 Oct 12.


Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons.

Park CY, Halevy T, Lee DR, Sung JJ, Lee JS, Yanuka O, Benvenisty N, Kim DW.

Cell Rep. 2015 Oct 13;13(2):234-41. doi: 10.1016/j.celrep.2015.08.084. Epub 2015 Oct 1.


FMR1 epigenetic silencing commonly occurs in undifferentiated fragile X-affected embryonic stem cells.

Avitzour M, Mor-Shaked H, Yanovsky-Dagan S, Aharoni S, Altarescu G, Renbaum P, Eldar-Geva T, Schonberger O, Levy-Lahad E, Epsztejn-Litman S, Eiges R.

Stem Cell Reports. 2014 Nov 11;3(5):699-706. doi: 10.1016/j.stemcr.2014.09.001. Epub 2014 Oct 3.


Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome.

Colak D, Zaninovic N, Cohen MS, Rosenwaks Z, Yang WY, Gerhardt J, Disney MD, Jaffrey SR.

Science. 2014 Feb 28;343(6174):1002-5. doi: 10.1126/science.1245831.


Evaluation of the human fragile X mental retardation 1 polymerase chain reaction reagents to amplify the FMR1 gene: testing in a clinical diagnostic laboratory.

Nahhas FA, Monroe TJ, Prior TW, Botma PI, Fang J, Snyder PJ, Talbott SL, Feldman GL.

Genet Test Mol Biomarkers. 2012 Mar;16(3):187-92. doi: 10.1089/gtmb.2011.0128. Epub 2011 Oct 12.


Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome.

Xie N, Gong H, Suhl JA, Chopra P, Wang T, Warren ST.

PLoS One. 2016 Oct 21;11(10):e0165499. doi: 10.1371/journal.pone.0165499. eCollection 2016.


Molecular diagnosis of fragile X syndrome using methylation sensitive techniques in a cohort of patients with intellectual disability.

Chaudhary AG, Hussein IR, Abuzenadah A, Gari M, Bassiouni R, Sogaty S, Lary S, Al-Quaiti M, Al Balwi M, Al Qahtani M.

Pediatr Neurol. 2014 Apr;50(4):368-76. doi: 10.1016/j.pediatrneurol.2013.11.020. Epub 2013 Dec 4.


FMR1 CGG repeat lengths mediate different regulation of reporter gene expression in comparative transient and locus specific integration assays.

SĂžlvsten C, Nielsen AL.

Gene. 2011 Oct 15;486(1-2):15-22. doi: 10.1016/j.gene.2011.06.034. Epub 2011 Jul 13.


Fragile X syndrome: the FMR1 CGG repeat distribution among world populations.

Peprah E.

Ann Hum Genet. 2012 Mar;76(2):178-91. doi: 10.1111/j.1469-1809.2011.00694.x. Epub 2011 Dec 21. Review.


Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells.

Coffee B, Zhang F, Warren ST, Reines D.

Nat Genet. 1999 May;22(1):98-101. Erratum in: Nat Genet 1999 Jun;22(2):209.


[Chromatin changes caused by CGG repeat expansion in fmr1 gene].

Yudkin DV, Lemskaya NA, Grischenko IV, Dolskiy AA.

Mol Biol (Mosk). 2015 Mar-Apr;49(2):205-11. Review. Russian.

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