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Items: 1 to 20 of 83

1.

Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.

Johnston JB, Ouellet H, Ortiz de Montellano PR.

J Biol Chem. 2010 Nov 19;285(47):36352-60. doi: 10.1074/jbc.M110.161117. Epub 2010 Sep 15.

2.

Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one.

Ouellet H, Guan S, Johnston JB, Chow ED, Kells PM, Burlingame AL, Cox JS, Podust LM, de Montellano PR.

Mol Microbiol. 2010 Aug;77(3):730-42. doi: 10.1111/j.1365-2958.2010.07243.x. Epub 2010 Jun 10.

3.

A highly conserved mycobacterial cholesterol catabolic pathway.

García-Fernández E, Frank DJ, Galán B, Kells PM, Podust LM, García JL, Ortiz de Montellano PR.

Environ Microbiol. 2013 Aug;15(8):2342-59. doi: 10.1111/1462-2920.12108. Epub 2013 Mar 14.

4.

Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors.

Frank DJ, Zhao Y, Wong SH, Basudhar D, De Voss JJ, Ortiz de Montellano PR.

J Biol Chem. 2016 Apr 1;291(14):7325-33. doi: 10.1074/jbc.M115.708172. Epub 2016 Feb 1.

5.

Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.

Johnston JB, Singh AA, Clary AA, Chen CK, Hayes PY, Chow S, De Voss JJ, Ortiz de Montellano PR.

Bioorg Med Chem. 2012 Jul 1;20(13):4064-81. doi: 10.1016/j.bmc.2012.05.003. Epub 2012 May 11.

6.

Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.

Capyk JK, Kalscheuer R, Stewart GR, Liu J, Kwon H, Zhao R, Okamoto S, Jacobs WR Jr, Eltis LD, Mohn WW.

J Biol Chem. 2009 Dec 18;284(51):35534-42. doi: 10.1074/jbc.M109.072132.

7.

Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.

Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW.

J Biol Chem. 2010 Dec 3;285(49):38270-82. doi: 10.1074/jbc.M110.164293. Epub 2010 Sep 30.

8.

Genetic and mass spectrometric tools for elucidating the physiological function(s) of cytochrome P450 enzymes from Mycobacterium tuberculosis.

Ouellet H, Chow ED, Guan S, Cox JS, Burlingame AL, de Montellano PR.

Methods Mol Biol. 2013;987:79-94. doi: 10.1007/978-1-62703-321-3_7.

PMID:
23475669
9.

Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis.

Frank DJ, Waddling CA, La M, Ortiz de Montellano PR.

Biochemistry. 2015 Nov 24;54(46):6909-16. doi: 10.1021/acs.biochem.5b01029. Epub 2015 Nov 11.

10.

The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.

McLean KJ, Lafite P, Levy C, Cheesman MR, Mast N, Pikuleva IA, Leys D, Munro AW.

J Biol Chem. 2009 Dec 18;284(51):35524-33. doi: 10.1074/jbc.M109.032706.

11.

Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1.

Rosłoniec KZ, Wilbrink MH, Capyk JK, Mohn WW, Ostendorf M, van der Geize R, Dijkhuizen L, Eltis LD.

Mol Microbiol. 2009 Dec;74(5):1031-43. doi: 10.1111/j.1365-2958.2009.06915.x. Epub 2009 Oct 15.

12.

Cholesterol ester oxidation by mycobacterial cytochrome P450.

Frank DJ, Madrona Y, Ortiz de Montellano PR.

J Biol Chem. 2014 Oct 31;289(44):30417-25. doi: 10.1074/jbc.M114.602771. Epub 2014 Sep 10.

13.

Metabolism of a novel side chain modified Delta8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1.

Pettersson H, Norlin M, Andersson U, Pikuleva I, Björkhem I, Misharin AY, Wikvall K.

Biochim Biophys Acta. 2008 Aug;1781(8):383-90. doi: 10.1016/j.bbalip.2008.05.009. Epub 2008 Jun 11.

14.

Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1.

Ouellet H, Kells PM, Ortiz de Montellano PR, Podust LM.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):332-7. doi: 10.1016/j.bmcl.2010.11.007. Epub 2010 Nov 5.

16.

ChoD and HsdD can be dispensable for cholesterol degradation in mycobacteria.

Brzostek A, Rumijowska-Galewicz A, Dziadek B, Wojcik EA, Dziadek J.

J Steroid Biochem Mol Biol. 2013 Mar;134:1-7. doi: 10.1016/j.jsbmb.2012.09.028. Epub 2012 Oct 12.

PMID:
23064392
17.

Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

McLean KJ, Carroll P, Lewis DG, Dunford AJ, Seward HE, Neeli R, Cheesman MR, Marsollier L, Douglas P, Smith WE, Rosenkrands I, Cole ST, Leys D, Parish T, Munro AW.

J Biol Chem. 2008 Nov 28;283(48):33406-16. doi: 10.1074/jbc.M802115200. Epub 2008 Sep 24.

18.

FadD19 of Rhodococcus rhodochrous DSM43269, a steroid-coenzyme A ligase essential for degradation of C-24 branched sterol side chains.

Wilbrink MH, Petrusma M, Dijkhuizen L, van der Geize R.

Appl Environ Microbiol. 2011 Jul;77(13):4455-64. doi: 10.1128/AEM.00380-11. Epub 2011 May 20.

19.

The Mycobacterium tuberculosis cytochrome P450 system.

Ouellet H, Johnston JB, Ortiz de Montellano PR.

Arch Biochem Biophys. 2010 Jan 1;493(1):82-95. doi: 10.1016/j.abb.2009.07.011. Epub 2009 Jul 25. Review.

20.

Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.

McLean KJ, Dunford AJ, Neeli R, Driscoll MD, Munro AW.

Arch Biochem Biophys. 2007 Aug 15;464(2):228-40. Epub 2007 Apr 10. Review.

PMID:
17482138

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