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The impact of ex vivo clinical grade activation protocols on human T-cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy.

Tumeh PC, Koya RC, Chodon T, Graham NA, Graeber TG, Comin-Anduix B, Ribas A.

J Immunother. 2010 Oct;33(8):759-68. doi: 10.1097/CJI.0b013e3181f1d644.


Optimization of lentiviral vector transduction into peripheral blood mononuclear cells in combination with the fibronectin fragment CH-296 stimulation.

Chono H, Goto Y, Yamakawa S, Tanaka S, Tosaka Y, Nukaya I, Mineno J.

J Biochem. 2011 Mar;149(3):285-92. doi: 10.1093/jb/mvq135. Epub 2010 Nov 23.


A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors.

Yang S, Dudley ME, Rosenberg SA, Morgan RA.

J Immunother. 2010 Jul-Aug;33(6):648-58. doi: 10.1097/CJI.0b013e3181e311cb.


Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications.

Han S, Huang Y, Liang Y, Ho Y, Wang Y, Chang LJ.

J Hematol Oncol. 2009 Aug 6;2:34. doi: 10.1186/1756-8722-2-34.


Expansion and fibronectin-enhanced retroviral transduction of primary human T lymphocytes for adoptive immunotherapy.

Stockschläder M, Haiss M, Exner S, Schmah O, Veelken H, Follo M, Rüger R, Finke J.

J Hematother Stem Cell Res. 1999 Aug;8(4):401-10.


Ex vivo enrichment of circulating anti-tumor T cells from both cutaneous and ocular melanoma patients: clinical implications for adoptive cell transfer therapy.

Mazzarella T, Cambiaghi V, Rizzo N, Pilla L, Parolini D, Orsenigo E, Colucci A, Modorati G, Doglioni C, Parmiani G, Maccalli C.

Cancer Immunol Immunother. 2012 Aug;61(8):1169-82. doi: 10.1007/s00262-011-1179-z. Epub 2011 Dec 30.


Influence of ex vivo expansion and retrovirus-mediated gene transfer on primary T lymphocyte phenotype and functions.

Sauce D, Tonnelier N, Duperrier A, Petracca B, de Carvalho Bittencourt M, Saadi M, Saas P, Ferrand C, Herve P, Tiberghien P, Robinet E.

J Hematother Stem Cell Res. 2002 Dec;11(6):929-40.


Cord blood T cells cultured with IL-7 in addition to IL-2 exhibit a higher degree of polyfunctionality and superior proliferation potential.

Berglund S, Gertow J, Magalhaes I, Mattsson J, Uhlin M.

J Immunother. 2013 Oct;36(8):432-41. doi: 10.1097/CJI.0b013e3182a802f6.


Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy.

Portevin D, Poupot M, Rolland O, Turrin CO, Fournié JJ, Majoral JP, Caminade AM, Poupot R.

J Transl Med. 2009 Sep 24;7:82. doi: 10.1186/1479-5876-7-82.


Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale.

Wang X, Naranjo A, Brown CE, Bautista C, Wong CW, Chang WC, Aguilar B, Ostberg JR, Riddell SR, Forman SJ, Jensen MC.

J Immunother. 2012 Nov-Dec;35(9):689-701. doi: 10.1097/CJI.0b013e318270dec7.


Optimization of ex vivo activation and expansion of macaque primary CD4-enriched peripheral blood mononuclear cells for use in anti-HIV immunotherapy and gene therapy strategies.

Zhang D, Murakami A, Johnson RP, Sui J, Cheng J, Bai J, Marasco WA.

J Acquir Immune Defic Syndr. 2003 Mar 1;32(3):245-54.


Retrovirus-mediated gene transfer in human primary T lymphocytes induces an activation- and transduction/selection-dependent TCR-B variable chain repertoire skewing of gene-modified cells.

Coito S, Sauce D, Duperrier A, Certoux JM, Bonyhadi M, Collette A, Kuehlcke K, Hervé P, Tiberghien P, Robinet E, Ferrand C.

Stem Cells Dev. 2004 Feb;13(1):71-81.


Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-gamma secretion for adjuvant immunotherapy.

Feuchtinger T, Lang P, Hamprecht K, Schumm M, Greil J, Jahn G, Niethammer D, Einsele H.

Exp Hematol. 2004 Mar;32(3):282-9.


Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors.

Zhou Q, Uhlig KM, Muth A, Kimpel J, Lévy C, Münch RC, Seifried J, Pfeiffer A, Trkola A, Coulibaly C, von Laer D, Wels WS, Hartwig UF, Verhoeyen E, Buchholz CJ.

J Immunol. 2015 Sep 1;195(5):2493-501. doi: 10.4049/jimmunol.1500956. Epub 2015 Jul 31.


Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation.

Feuchtinger T, Richard C, Joachim S, Scheible MH, Schumm M, Hamprecht K, Martin D, Jahn G, Handgretinger R, Lang P.

J Immunother. 2008 Feb-Mar;31(2):199-206. doi: 10.1097/CJI.0b013e31815ef862.


Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer.

Lamers CH, Willemsen RA, Luider BA, Debets R, Bolhuis RL.

Cancer Gene Ther. 2002 Jul;9(7):613-23.

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