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Items: 1 to 20 of 90

1.

In-silico characterization of the effects of phosphorylated tyrosines 86 and 106 on structure and binding of MAL: insight into hyperinflammatory response to infection by the human malaria parasites.

Niazi UH, Bibby J, Sutcliffe MJ.

J Recept Signal Transduct Res. 2011 Feb;31(1):53-65. doi: 10.3109/10799893.2010.512014. Epub 2010 Sep 8.

PMID:
20822478
2.

Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106.

Paracha RZ, Ali A, Ahmad J, Hussain R, Niazi U, Muhammad SA.

Comput Biol Chem. 2014 Aug;51:22-35. doi: 10.1016/j.compbiolchem.2014.04.001. Epub 2014 Apr 20.

PMID:
24840642
3.

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.

Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA.

J Biol Chem. 2006 Apr 14;281(15):10489-95. Epub 2006 Jan 26. Erratum in: J Biol Chem. 2016 Dec 9;291(50):26240.

4.

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection.

Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, Roversi P, Kellie S, Sweet MJ, Mansell A, Gay NJ, Martin JL, Kobe B.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14879-84. doi: 10.1073/pnas.1104780108. Epub 2011 Aug 22.

5.

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

Dunne A, Ejdeback M, Ludidi PL, O'Neill LA, Gay NJ.

J Biol Chem. 2003 Oct 17;278(42):41443-51. Epub 2003 Jul 29.

6.

In silico approach to inhibition of signaling pathways of Toll-like receptors 2 and 4 by ST2L.

Basith S, Manavalan B, Govindaraj RG, Choi S.

PLoS One. 2011;6(8):e23989. doi: 10.1371/journal.pone.0023989. Epub 2011 Aug 29.

7.

Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.

Blood. 2004 Mar 15;103(6):2229-37. Epub 2003 Nov 20.

8.

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).

Bovijn C, Desmet AS, Uyttendaele I, Van Acker T, Tavernier J, Peelman F.

J Biol Chem. 2013 Apr 26;288(17):12054-66. doi: 10.1074/jbc.M112.415810. Epub 2013 Mar 4.

9.

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site.

Ulrichts P, Bovijn C, Lievens S, Beyaert R, Tavernier J, Peelman F.

J Cell Sci. 2010 Jan 15;123(Pt 2):256-65. doi: 10.1242/jcs.056002.

10.

Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.

Lin Z, Lu J, Zhou W, Shen Y.

PLoS One. 2012;7(4):e34202. doi: 10.1371/journal.pone.0034202. Epub 2012 Apr 2.

11.

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A.

J Biol Chem. 2009 Sep 4;284(36):24192-203. doi: 10.1074/jbc.M109.023044. Epub 2009 Jul 10.

12.

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.

Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA.

Nature. 2001 Sep 6;413(6851):78-83.

PMID:
11544529
13.

Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: a computational approach.

Gong J, Wei T, Stark RW, Jamitzky F, Heckl WM, Anders HJ, Lech M, Rössle SC.

J Struct Biol. 2010 Mar;169(3):323-30. doi: 10.1016/j.jsb.2009.12.007. Epub 2009 Dec 16.

PMID:
20025973
14.

Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling.

Nada M, Ohnishi H, Tochio H, Kato Z, Kimura T, Kubota K, Yamamoto T, Kamatari YO, Tsutsumi N, Shirakawa M, Kondo N.

Mol Immunol. 2012 Oct;52(3-4):108-16. doi: 10.1016/j.molimm.2012.05.003. Epub 2012 Jun 4.

PMID:
22673208
15.

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway.

Li C, Zienkiewicz J, Hawiger J.

J Biol Chem. 2005 Jul 15;280(28):26152-9. Epub 2005 Apr 22.

16.
17.

Modulation of Toll-interleukin 1 receptor mediated signaling.

Li X, Qin J.

J Mol Med (Berl). 2005 Apr;83(4):258-66. Epub 2005 Jan 21. Review.

PMID:
15662540
18.

Formal modeling and analysis of the MAL-associated biological regulatory network: insight into cerebral malaria.

Ahmad J, Niazi U, Mansoor S, Siddique U, Bibby J.

PLoS One. 2012;7(3):e33532. doi: 10.1371/journal.pone.0033532. Epub 2012 Mar 30.

19.

Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling.

Kubo-Murai M, Hazeki K, Sukenobu N, Yoshikawa K, Nigorikawa K, Inoue K, Yamamoto T, Matsumoto M, Seya T, Inoue N, Hazeki O.

Mol Immunol. 2007 Mar;44(9):2257-64. Epub 2006 Dec 11.

PMID:
17161867
20.

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