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Items: 1 to 20 of 191

1.

Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis.

Lacher MD, Pincheira R, Zhu Z, Camoretti-Mercado B, Matli M, Warren RS, Castro AF.

Oncogene. 2010 Dec 16;29(50):6543-56. doi: 10.1038/onc.2010.393. Epub 2010 Sep 6.

PMID:
20818424
2.
3.

Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer.

Lacher MD, Pincheira RJ, Castro AF.

Small GTPases. 2011 Jul;2(4):211-216. Epub 2011 Jul 1.

4.

Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis.

Makovski V, Haklai R, Kloog Y.

Int J Cancer. 2012 Mar 15;130(6):1420-9. doi: 10.1002/ijc.26139. Epub 2011 Aug 1.

5.

Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival.

Campos T, Ziehe J, Fuentes-Villalobos F, Riquelme O, Peña D, Troncoso R, Lavandero S, Morin V, Pincheira R, Castro AF.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1200-7. doi: 10.1016/j.bbamcr.2016.03.009. Epub 2016 Mar 11.

6.

Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway.

Makovski V, Jacob-Hirsch J, Gefen-Dor C, Shai B, Ehrlich M, Rechavi G, Kloog Y.

Cell Death Dis. 2014 Dec 4;5:e1557. doi: 10.1038/cddis.2014.502.

7.

Measurements of TSC2 GAP activity toward Rheb.

Li Y, Inoki K, Vikis H, Guan KL.

Methods Enzymol. 2006;407:46-54.

PMID:
16757313
8.

mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo.

Zhang Y, Xu S, Lin J, Yao G, Han Z, Liang B, Zou Z, Chen Z, Song Q, Dai Y, Gao T, Liu A, Bai X.

Breast Cancer Res Treat. 2012 Nov;136(2):379-88. doi: 10.1007/s10549-012-2270-7. Epub 2012 Sep 29.

PMID:
23053656
9.

PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.

Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H.

J Biol Chem. 2014 Oct 24;289(43):29739-49. doi: 10.1074/jbc.M114.584821. Epub 2014 Aug 27.

10.

Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.

Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K.

J Biol Chem. 2011 Sep 16;286(37):32651-60. doi: 10.1074/jbc.M111.238014. Epub 2011 Jul 22.

11.
12.

p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.

Agarwal S, Bell CM, Taylor SM, Moran RG.

Mol Cancer Res. 2016 Jan;14(1):66-77. doi: 10.1158/1541-7786.MCR-15-0159. Epub 2015 Sep 18.

13.

Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.

Yasuda S, Sugiura H, Katsurabayashi S, Shimada T, Tanaka H, Takasaki K, Iwasaki K, Kobayashi T, Hino O, Yamagata K.

Sci Rep. 2014 Jun 3;4:5155. doi: 10.1038/srep05155.

14.

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.

Neuman NA, Henske EP.

EMBO Mol Med. 2011 Apr;3(4):189-200. doi: 10.1002/emmm.201100131. Epub 2011 Mar 16. Review.

15.

Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.

Robb VA, Astrinidis A, Henske EP.

Mod Pathol. 2006 Jun;19(6):839-46. Erratum in: Mod Pathol. 2006 Jun;19(6):889.

16.

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.

17.

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8286-91. doi: 10.1073/pnas.0712268105. Epub 2008 Jun 11.

18.

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.

Castro AF, Rebhun JF, Clark GJ, Quilliam LA.

J Biol Chem. 2003 Aug 29;278(35):32493-6. Epub 2003 Jul 3.

19.

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.

Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J.

Nat Cell Biol. 2011 Mar;13(3):263-72. doi: 10.1038/ncb2168. Epub 2011 Feb 20.

20.

TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity.

Ohsawa M, Kobayashi T, Okura H, Igarashi T, Mizuguchi M, Hino O.

PLoS One. 2013;8(1):e54503. doi: 10.1371/journal.pone.0054503. Epub 2013 Jan 23.

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