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Items: 1 to 20 of 202

1.

Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.

Mancuso DJ, Sims HF, Yang K, Kiebish MA, Su X, Jenkins CM, Guan S, Moon SH, Pietka T, Nassir F, Schappe T, Moore K, Han X, Abumrad NA, Gross RW.

J Biol Chem. 2010 Nov 19;285(47):36495-510. doi: 10.1074/jbc.M110.115766. Epub 2010 Sep 3.

2.

Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.

Song H, Wohltmann M, Bao S, Ladenson JH, Semenkovich CF, Turk J.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1097-114. doi: 10.1152/ajpendo.00780.2009. Epub 2010 Feb 23.

3.

Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.

Mancuso DJ, Sims HF, Han X, Jenkins CM, Guan SP, Yang K, Moon SH, Pietka T, Abumrad NA, Schlesinger PH, Gross RW.

J Biol Chem. 2007 Nov 30;282(48):34611-22. Epub 2007 Oct 8.

4.

Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids.

Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EW, Cooney GJ, Ye JM.

Diabetes. 2009 Nov;58(11):2547-54. doi: 10.2337/db09-0784. Epub 2009 Aug 31. Erratum in: Diabetes. 2010 May;59(5):1283.

5.

Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release.

Moon SH, Jenkins CM, Kiebish MA, Sims HF, Mancuso DJ, Gross RW.

J Biol Chem. 2012 Aug 24;287(35):29837-50. doi: 10.1074/jbc.M112.373654. Epub 2012 Jul 9.

6.

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation.

Hoy AJ, Bruce CR, Turpin SM, Morris AJ, Febbraio MA, Watt MJ.

Endocrinology. 2011 Jan;152(1):48-58. doi: 10.1210/en.2010-0661. Epub 2010 Nov 24.

PMID:
21106876
7.

Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1.

Katterle Y, Keipert S, Hof J, Klaus S.

Physiol Genomics. 2008 Feb 19;32(3):352-9. Epub 2007 Nov 27.

8.
9.

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC.

PLoS One. 2009;4(3):e4937. doi: 10.1371/journal.pone.0004937. Epub 2009 Mar 19.

11.

Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.

Moon SH, Jenkins CM, Liu X, Guan S, Mancuso DJ, Gross RW.

J Biol Chem. 2012 Apr 27;287(18):14880-95. doi: 10.1074/jbc.M111.336776. Epub 2012 Mar 2.

12.

Small interfering RNA knockdown of calcium-independent phospholipases A2 beta or gamma inhibits the hormone-induced differentiation of 3T3-L1 preadipocytes.

Su X, Mancuso DJ, Bickel PE, Jenkins CM, Gross RW.

J Biol Chem. 2004 May 21;279(21):21740-8. Epub 2004 Mar 15.

13.

High fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance.

Hoeks J, Wilde Jd, Hulshof MF, Berg SA, Schaart G, Dijk KW, Smit E, Mariman EC.

PLoS One. 2011;6(11):e27274. doi: 10.1371/journal.pone.0027274. Epub 2011 Nov 28.

14.

Eicosapentaenoic acid reduces adipocyte hypertrophy and inflammation in diet-induced obese mice in an adiposity-independent manner.

LeMieux MJ, Kalupahana NS, Scoggin S, Moustaid-Moussa N.

J Nutr. 2015 Mar;145(3):411-7. doi: 10.3945/jn.114.202952. Epub 2014 Dec 31.

15.

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice.

Keipert S, Voigt A, Klaus S.

Aging Cell. 2011 Feb;10(1):122-36. doi: 10.1111/j.1474-9726.2010.00648.x. Epub 2010 Dec 7.

16.

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.

Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS.

Nat Med. 2009 Feb;15(2):159-68. doi: 10.1038/nm.1904. Epub 2009 Jan 11.

17.

Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.

Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED.

Endocrinology. 2012 Jun;153(6):2677-88. doi: 10.1210/en.2011-2147. Epub 2012 Apr 17.

18.

Similar changes in muscle lipid metabolism are induced by chronic high-fructose feeding and high-fat feeding in C57BL/J6 mice.

Song GY, Ren LP, Chen SC, Wang C, Liu N, Wei LM, Li F, Sun W, Peng LB, Tang Y.

Clin Exp Pharmacol Physiol. 2012 Dec;39(12):1011-8. doi: 10.1111/1440-1681.12017.

PMID:
23039229
19.

Butyrate improves insulin sensitivity and increases energy expenditure in mice.

Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J.

Diabetes. 2009 Jul;58(7):1509-17. doi: 10.2337/db08-1637. Epub 2009 Apr 14.

20.

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.

Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK.

Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E30-9. Epub 2005 Feb 8.

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