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Items: 1 to 20 of 135

1.

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency.

Henneman L, Schneiders MS, Turkenburg M, Waterham HR.

J Inherit Metab Dis. 2010 Oct;33(5):625-32. doi: 10.1007/s10545-010-9173-8. Epub 2010 Sep 3.

2.

Unprenylated RhoA contributes to IL-1β hypersecretion in mevalonate kinase deficiency model through stimulation of Rac1 activity.

van der Burgh R, Pervolaraki K, Turkenburg M, Waterham HR, Frenkel J, Boes M.

J Biol Chem. 2014 Oct 3;289(40):27757-65. doi: 10.1074/jbc.M114.571810. Epub 2014 Aug 8.

3.

HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation.

Kuijk LM, Beekman JM, Koster J, Waterham HR, Frenkel J, Coffer PJ.

Blood. 2008 Nov 1;112(9):3563-73. doi: 10.1182/blood-2008-03-144667. Epub 2008 Aug 6.

4.

A role for geranylgeranylation in interleukin-1beta secretion.

Mandey SH, Kuijk LM, Frenkel J, Waterham HR.

Arthritis Rheum. 2006 Nov;54(11):3690-5.

5.

Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells.

Nègre-Aminou P, van Erck M, van Leeuwen RE, Collard JG, Cohen LH.

Biochem Pharmacol. 2001 Apr 15;61(8):991-8.

PMID:
11286990
6.

Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients.

Houten SM, Schneiders MS, Wanders RJ, Waterham HR.

J Biol Chem. 2003 Feb 21;278(8):5736-43. Epub 2002 Dec 10.

7.
8.

Mutational spectrum and genotype-phenotype correlations in mevalonate kinase deficiency.

Mandey SH, Schneiders MS, Koster J, Waterham HR.

Hum Mutat. 2006 Aug;27(8):796-802.

PMID:
16835861
9.

Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.

Takeda N, Kondo M, Ito S, Ito Y, Shimokata K, Kume H.

Am J Respir Cell Mol Biol. 2006 Dec;35(6):722-9. Epub 2006 Jul 20.

PMID:
16858009
10.

Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency.

Schneiders MS, Houten SM, Turkenburg M, Wanders RJ, Waterham HR.

Arthritis Rheum. 2006 Jul;54(7):2306-13.

11.

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency.

Tricarico PM, Romeo A, Gratton R, Crovella S, Celsi F.

Cell Physiol Biochem. 2017;41(4):1649-1660. doi: 10.1159/000471235. Epub 2017 Mar 28.

12.

Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.

Lee MH, Cho YS, Han YM.

Stem Cells. 2007 Jul;25(7):1654-63. Epub 2007 Apr 26.

13.

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

Park HJ, Kong D, Iruela-Arispe L, Begley U, Tang D, Galper JB.

Circ Res. 2002 Jul 26;91(2):143-50.

14.

Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.

Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB.

Life Sci. 2006 Sep 5;79(15):1484-92. Epub 2006 Apr 29.

PMID:
16740276
15.

Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation.

Normand S, Massonnet B, Delwail A, Favot L, Cuisset L, Grateau G, Morel F, Silvain C, Lecron JC.

Eur Cytokine Netw. 2009 Sep;20(3):101-7. doi: 10.1684/ecn.2009.0163. Review.

16.

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.

Jurczyluk J, Munoz MA, Skinner OP, Chai RC, Ali N, Palendira U, Quinn JM, Preston A, Tangye SG, Brown AJ, Argent E, Ziegler JB, Mehr S, Rogers MJ.

Immunol Cell Biol. 2016 Nov;94(10):994-999. doi: 10.1038/icb.2016.58. Epub 2016 Jul 5.

17.

Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.

Weernink PA, Meletiadis K, Hommeltenberg S, Hinz M, Ishihara H, Schmidt M, Jakobs KH.

J Biol Chem. 2004 Feb 27;279(9):7840-9. Epub 2003 Dec 17.

18.

Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.

Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM.

J Biol Chem. 2002 May 3;277(18):15309-16. Epub 2002 Feb 11.

19.

Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes.

Massonnet B, Normand S, Moschitz R, Delwail A, Favot L, Garcia M, Bourmeyster N, Cuisset L, Grateau G, Morel F, Silvain C, Lecron JC.

Eur Cytokine Netw. 2009 Sep;20(3):112-20. doi: 10.1684/ecn.2009.0162.

20.

Mevalonate kinase deficiency, a metabolic autoinflammatory disease.

van der Burgh R, Ter Haar NM, Boes ML, Frenkel J.

Clin Immunol. 2013 Jun;147(3):197-206. doi: 10.1016/j.clim.2012.09.011. Epub 2012 Oct 4. Review.

PMID:
23110805

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