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Items: 1 to 20 of 289

1.

Role of EP4 receptor and prostaglandin transporter in prostaglandin E2-induced alteration in colonic epithelial barrier integrity.

Lejeune M, Leung P, Beck PL, Chadee K.

Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1097-105. doi: 10.1152/ajpgi.00280.2010. Epub 2010 Sep 2.

2.

Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines.

Dey I, Giembycz MA, Chadee K.

Br J Pharmacol. 2009 Feb;156(3):475-85. doi: 10.1111/j.1476-5381.2008.00056.x. Epub 2009 Jan 23.

3.

Expression of the EP4 prostaglandin E2 receptor subtype with rat dextran sodium sulphate colitis: colitis suppression by a selective agonist, ONO-AE1-329.

Nitta M, Hirata I, Toshina K, Murano M, Maemura K, Hamamoto N, Sasaki S, Yamauchi H, Katsu K.

Scand J Immunol. 2002 Jul;56(1):66-75.

4.

Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation.

Iwanaga K, Okada M, Murata T, Hori M, Ozaki H.

J Pharmacol Exp Ther. 2012 Mar;340(3):604-11. doi: 10.1124/jpet.111.189845. Epub 2011 Dec 2.

5.

E-prostanoid (EP)2/EP4 receptor-dependent maturation of human monocyte-derived dendritic cells and induction of helper T2 polarization.

Kubo S, Takahashi HK, Takei M, Iwagaki H, Yoshino T, Tanaka N, Mori S, Nishibori M.

J Pharmacol Exp Ther. 2004 Jun;309(3):1213-20. Epub 2004 Feb 10.

6.

Distribution of prostaglandin E receptors in the rat gastrointestinal tract.

Ding M, Kinoshita Y, Kishi K, Nakata H, Hassan S, Kawanami C, Sugimoto Y, Katsuyama M, Negishi M, Narumiya S, Ichikawa A, Chiba T.

Prostaglandins. 1997 Mar;53(3):199-216.

PMID:
9206801
7.

EP4 receptors mediate prostaglandin E2, tumour necrosis factor alpha and interleukin 1beta-induced ion secretion in human and mouse colon mucosa.

Fairbrother SE, Smith JE, Borman RA, Cox HM.

Eur J Pharmacol. 2012 Nov 5;694(1-3):89-97. doi: 10.1016/j.ejphar.2012.06.020. Epub 2012 Jun 23.

PMID:
22732652
8.

Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.

Miyaura C, Inada M, Suzawa T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Suda T.

J Biol Chem. 2000 Jun 30;275(26):19819-23.

9.

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.

Kabashima K, Saji T, Murata T, Nagamachi M, Matsuoka T, Segi E, Tsuboi K, Sugimoto Y, Kobayashi T, Miyachi Y, Ichikawa A, Narumiya S.

J Clin Invest. 2002 Apr;109(7):883-93.

10.

Prostaglandin E2 produced by Entamoeba histolytica binds to EP4 receptors and stimulates interleukin-8 production in human colonic cells.

Dey I, Chadee K.

Infect Immun. 2008 Nov;76(11):5158-63. doi: 10.1128/IAI.00645-08. Epub 2008 Aug 18.

11.

The prevention of colitis by E Prostanoid receptor 4 agonist through enhancement of epithelium survival and regeneration.

Jiang GL, Nieves A, Im WB, Old DW, Dinh DT, Wheeler L.

J Pharmacol Exp Ther. 2007 Jan;320(1):22-8. Epub 2006 Sep 28.

12.

Expression of prostaglandin receptors EP4 and FP in human lens epithelial cells.

Mukhopadhyay P, Bhattacherjee P, Andom T, Geoghegan TE, Andley UP, Paterson CA.

Invest Ophthalmol Vis Sci. 1999 Jan;40(1):105-12.

PMID:
9888433
13.

Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production.

Akaogi J, Yamada H, Kuroda Y, Nacionales DC, Reeves WH, Satoh M.

J Leukoc Biol. 2004 Jul;76(1):227-36. Epub 2004 Apr 1.

PMID:
15075356
14.

EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures.

Minamizaki T, Yoshiko Y, Kozai K, Aubin JE, Maeda N.

Bone. 2009 Jun;44(6):1177-85. doi: 10.1016/j.bone.2009.02.010. Epub 2009 Feb 21.

PMID:
19233324
15.

Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts.

Shoji M, Tanabe N, Mitsui N, Tanaka H, Suzuki N, Takeichi O, Sugaya A, Maeno M.

Life Sci. 2006 Mar 20;78(17):2012-8. Epub 2005 Nov 14.

PMID:
16289620
16.

Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity.

Takeuchi K, Kato S, Amagase K.

J Pharmacol Sci. 2010;114(3):248-61. Epub 2010 Oct 28. Review.

17.

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier.

Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC.

Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G208-16. Epub 2007 Oct 25.

18.

Prostaglandin E2 inhibits mineralization and enhances matrix metalloproteinase-13 in mature cementoblasts mainly via the EP4 pathway.

Oka H, Miyauchi M, Sakamoto K, Kitagawa M, Noguchi K, Somerman MJ, Takata T.

Arch Oral Biol. 2008 Mar;53(3):243-9. Epub 2007 Nov 28.

PMID:
18045572
19.

Prostaglandin E(2) stimulates rat and human colonic mucin exocytosis via the EP(4) receptor.

Belley A, Chadee K.

Gastroenterology. 1999 Dec;117(6):1352-62.

PMID:
10579976
20.

Prostanoid receptors in intestinal epithelium: selective expression, function, and change with inflammation.

Takafuji V, Cosme R, Lublin D, Lynch K, Roche JK.

Prostaglandins Leukot Essent Fatty Acids. 2000 Oct;63(4):223-35.

PMID:
11049698

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