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Chronic treatment with fibrates elevates superoxide dismutase in adult mouse brain microvessels.

Wang G, Liu X, Guo Q, Namura S.

Brain Res. 2010 Nov 4;1359:247-55. doi: 10.1016/j.brainres.2010.08.075.


Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice.

Guo Q, Wang G, Namura S.

J Cereb Blood Flow Metab. 2010 Jan;30(1):70-8. doi: 10.1038/jcbfm.2009.185. Erratum in: J Cereb Blood Flow Metab. 2010 Jan;30(1):242. Dosage error in article text.


Gemfibrozil pretreatment proved protection against acute restraint stress-induced changes in the male rats' hippocampus.

Khalaj L, Nejad SC, Mohammadi M, Zadeh SS, Pour MH, Ahmadiani A, Khodagholi F, Ashabi G, Alamdary SZ, Samami E.

Brain Res. 2013 Aug 21;1527:117-30. doi: 10.1016/j.brainres.2013.06.041.


Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential.

Hong M, Song KD, Lee HK, Yi S, Lee YS, Heo TH, Jun HS, Kim SJ.

In Vitro Cell Dev Biol Anim. 2016 Mar;52(3):349-55. doi: 10.1007/s11626-015-9979-7.


Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms.

Bhateja DK, Dhull DK, Gill A, Sidhu A, Sharma S, Reddy BV, Padi SS.

Eur J Pharmacol. 2012 Jan 5;674(1):33-43. doi: 10.1016/j.ejphar.2011.10.029.


Differential effects of gemfibrozil and fenofibrate on reverse cholesterol transport from macrophages to feces in vivo.

Rotllan N, Llaverías G, Julve J, Jauhiainen M, Calpe-Berdiel L, Hernández C, Simó R, Blanco-Vaca F, Escolà-Gil JC.

Biochim Biophys Acta. 2011 Feb;1811(2):104-10. doi: 10.1016/j.bbalip.2010.11.006.


Gemfibrozil not fenofibrate decreases systemic glucose level via PPARα.

Song D, Chu Z, Min L, Zhen T, Li P, Han L, Bu S, yang J, Gonzale FJ, Liu A.

Pharmazie. 2016 Apr;71(4):205-12.


Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes.

Zirlik A, Ernst S, Leugers A, Willecke F, Sobel BE, Bode C, Nordt TK.

Thromb Haemost. 2009 Jun;101(6):1060-9.


Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment.

Deplanque D, Gelé P, Pétrault O, Six I, Furman C, Bouly M, Nion S, Dupuis B, Leys D, Fruchart JC, Cecchelli R, Staels B, Duriez P, Bordet R.

J Neurosci. 2003 Jul 16;23(15):6264-71.


Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice.

Berthou L, Duverger N, Emmanuel F, Langouët S, Auwerx J, Guillouzo A, Fruchart JC, Rubin E, Denèfle P, Staels B, Branellec D.

J Clin Invest. 1996 Jun 1;97(11):2408-16.


Peroxisome proliferator-activated receptor α activation induces hepatic steatosis, suggesting an adverse effect.

Yan F, Wang Q, Xu C, Cao M, Zhou X, Wang T, Yu C, Jing F, Chen W, Gao L, Zhao J.

PLoS One. 2014 Jun 13;9(6):e99245. doi: 10.1371/journal.pone.0099245.


Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors.

Dong W, Li N, Gao D, Zhen H, Zhang X, Li F.

J Vasc Surg. 2008 Sep;48(3):709-14. doi: 10.1016/j.jvs.2008.04.007.


Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells.

Clavey V, Copin C, Mariotte MC, Baugé E, Chinetti G, Fruchart J, Fruchart JC, Dallongeville J, Staels B.

Cell Physiol Biochem. 1999;9(3):139-49.


Fibrates and fish oil, but not corn oil, up-regulate the expression of the cholesteryl ester transfer protein (CETP) gene.

Raposo HF, Patrício PR, Simões MC, Oliveira HC.

J Nutr Biochem. 2014 Jun;25(6):669-74. doi: 10.1016/j.jnutbio.2014.02.008.


Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice.

Inoue H, Jiang XF, Katayama T, Osada S, Umesono K, Namura S.

Neurosci Lett. 2003 Dec 11;352(3):203-6.


Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.

Kockx M, Gervois PP, Poulain P, Derudas B, Peters JM, Gonzalez FJ, Princen HM, Kooistra T, Staels B.

Blood. 1999 May 1;93(9):2991-8.


ABCD2 alters peroxisome proliferator-activated receptor α signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesity.

Liu X, Liu J, Liang S, Schlüter A, Fourcade S, Aslibekyan S, Pujol A, Graf GA.

Mol Pharmacol. 2014 Nov;86(5):505-13. doi: 10.1124/mol.114.092742.

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