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Items: 1 to 20 of 116

1.

Enhancer and competitive allosteric modulation model for G-protein-coupled receptors.

Pietra D, Borghini A, Breschi MC, Bianucci AM.

J Theor Biol. 2010 Dec 21;267(4):663-75. doi: 10.1016/j.jtbi.2010.08.024. Epub 2010 Aug 26.

PMID:
20800599
4.

Allosteric modulators of G-protein-coupled receptors.

May LT, Christopoulos A.

Curr Opin Pharmacol. 2003 Oct;3(5):551-6. Review.

PMID:
14559102
5.

Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.

Narlawar R, Lane JR, Doddareddy M, Lin J, Brussee J, Ijzerman AP.

J Med Chem. 2010 Apr 22;53(8):3028-37. doi: 10.1021/jm901252a.

PMID:
20345101
6.

Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.

Baraldi PG, Romagnoli R, Pavani MG, Nuñez Mdel C, Tabrizi MA, Shryock JC, Leung E, Moorman AR, Uluoglu C, Iannotta V, Merighi S, Borea PA.

J Med Chem. 2003 Feb 27;46(5):794-809.

PMID:
12593659
8.

Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects.

Valant C, Felder CC, Sexton PM, Christopoulos A.

Mol Pharmacol. 2012 Jan;81(1):41-52. doi: 10.1124/mol.111.074872. Epub 2011 Oct 11.

9.

Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies.

Barrondo S, Sallés J.

Neuropharmacology. 2009 Feb;56(2):455-62. doi: 10.1016/j.neuropharm.2008.09.018. Epub 2008 Oct 14.

PMID:
18951909
10.

Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors.

Avlani V, May LT, Sexton PM, Christopoulos A.

J Pharmacol Exp Ther. 2004 Mar;308(3):1062-72. Epub 2004 Jan 7.

11.

The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs.

Bhattacharya S, Youkey RL, Ghartey K, Leonard M, Linden J, Tucker AL.

Biochem J. 2006 May 15;396(1):139-46.

12.

PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs.

Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ.

Circ Res. 1996 Sep;79(3):415-23.

13.

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.

Casadó V, Ferrada C, Bonaventura J, Gracia E, Mallol J, Canela EI, Lluís C, Cortés A, Franco R.

Biochem Pharmacol. 2009 Dec 15;78(12):1456-63. doi: 10.1016/j.bcp.2009.07.012. Epub 2009 Jul 28.

PMID:
19643089
14.

Experimental design and estimation of parameters in complex radioligand binding systems.

Staschen CM, Homer LD.

J Pharmacokinet Biopharm. 1996 Dec;24(6):589-609.

PMID:
9300352
15.

Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.

Baraldi PG, Pavani MG, Leung E, Moorman AR, Varani K, Vincenzi F, Borea PA, Romagnoli R.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1402-4.

PMID:
16321527
16.

Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine.

Kollias-Baker C, Ruble J, Dennis D, Bruns RF, Linden J, Belardinelli L.

Circ Res. 1994 Dec;75(6):961-71.

17.

The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.

Avlani VA, McLoughlin DJ, Sexton PM, Christopoulos A.

J Pharmacol Exp Ther. 2008 Jun;325(3):927-34. doi: 10.1124/jpet.108.136978. Epub 2008 Mar 5.

18.

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K.

J Pharmacol Exp Ther. 2003 Oct;307(1):322-30. Epub 2003 Sep 3.

19.

G protein-coupled receptor allosterism and complexing.

Christopoulos A, Kenakin T.

Pharmacol Rev. 2002 Jun;54(2):323-74. Review.

20.

Differential effects of the adenosine A(1) receptor allosteric enhancer PD 81,723 on agonist binding to brain and adipocyte membranes.

Jarvis MF, Gessner G, Shapiro G, Merkel L, Myers M, Cox BF, Martin GE.

Brain Res. 1999 Sep 4;840(1-2):75-83.

PMID:
10517954

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