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Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1.

Shi CS, Kehrl JH.

Autophagy. 2010 Oct;6(7):986-7. doi: 10.4161/auto.6.7.13288. Epub 2010 Oct 9.


TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.

Shi CS, Kehrl JH.

Sci Signal. 2010 May 25;3(123):ra42. doi: 10.1126/scisignal.2000751.


Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M.

Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Review.


Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy.

Xu C, Liu J, Hsu LC, Luo Y, Xiang R, Chuang TH.

FASEB J. 2011 Aug;25(8):2700-10. doi: 10.1096/fj.10-167676. Epub 2011 May 4.


Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.

Zhan Z, Xie X, Cao H, Zhou X, Zhang XD, Fan H, Liu Z.

Autophagy. 2014 Feb;10(2):257-68. doi: 10.4161/auto.27162. Epub 2013 Dec 4.


The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.

Lin YC, Huang DY, Chu CL, Lin YL, Lin WW.

Sci Signal. 2013 Aug 20;6(289):ra71. doi: 10.1126/scisignal.2003973.


MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.

Shi CS, Kehrl JH.

J Biol Chem. 2008 Nov 28;283(48):33175-82. doi: 10.1074/jbc.M804478200. Epub 2008 Sep 4.


Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.

Lin SC, Chung JY, Lamothe B, Rajashankar K, Lu M, Lo YC, Lam AY, Darnay BG, Wu H.

J Mol Biol. 2008 Feb 15;376(2):526-40. doi: 10.1016/j.jmb.2007.11.092. Epub 2007 Dec 4.


Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20.

Inomata M, Niida S, Shibata K, Into T.

Cell Mol Life Sci. 2012 Mar;69(6):963-79. doi: 10.1007/s00018-011-0819-y. Epub 2011 Oct 2.


Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.

Jean-Charles PY, Zhang L, Wu JH, Han SO, Brian L, Freedman NJ, Shenoy SK.

J Biol Chem. 2016 Apr 1;291(14):7450-64. doi: 10.1074/jbc.M115.687129. Epub 2016 Feb 2.


Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia.

Kinsella S, König HG, Prehn JH.

eNeuro. 2016 May 12;3(2). pii: ENEURO.0099-15.2016. doi: 10.1523/ENEURO.0099-15.2016. eCollection 2016 Mar-Apr.


Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.

Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY.

Cell Signal. 2015 Dec;27(12):2524-33. doi: 10.1016/j.cellsig.2015.09.018. Epub 2015 Sep 30.


The VMP1-Beclin 1 interaction regulates autophagy induction.

Molejon MI, Ropolo A, Re AL, Boggio V, Vaccaro MI.

Sci Rep. 2013;3:1055. doi: 10.1038/srep01055. Epub 2013 Jan 11.


Beclin 1 bridges autophagy, apoptosis and differentiation.

Wang J.

Autophagy. 2008 Oct;4(7):947-8. Epub 2008 Oct 14.


The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7.

Ning S, Pagano JS.

J Virol. 2010 Jun;84(12):6130-8. doi: 10.1128/JVI.00364-10. Epub 2010 Apr 14.


MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A.

J Biol Chem. 2009 Sep 4;284(36):24192-203. doi: 10.1074/jbc.M109.023044. Epub 2009 Jul 10.


Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.

Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C.

Sci Signal. 2013 May 14;6(275):ra35. doi: 10.1126/scisignal.2003708.


The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4.

Dong W, Liu Y, Peng J, Chen L, Zou T, Xiao H, Liu Z, Li W, Bu Y, Qi Y.

J Biol Chem. 2006 Sep 8;281(36):26029-40. Epub 2006 Jul 10.


Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19211-6. doi: 10.1073/pnas.0810452105. Epub 2008 Dec 2.


DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.

Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, Sabanay H, Pinkas-Kramarski R, Kimchi A.

EMBO Rep. 2009 Mar;10(3):285-92. doi: 10.1038/embor.2008.246. Epub 2009 Jan 30.

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