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Items: 1 to 20 of 128

1.

Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.

Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, Comb MJ.

Sci Signal. 2010 Aug 24;3(136):ra64. doi: 10.1126/scisignal.2000998.

2.

p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.

Abe Y, Yoon SO, Kubota K, Mendoza MC, Gygi SP, Blenis J.

J Biol Chem. 2009 May 29;284(22):14939-48. doi: 10.1074/jbc.M900097200. Epub 2009 Mar 30.

4.

Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells.

Edelstein J, Hao T, Cao Q, Morales L, Rockwell P.

Cell Signal. 2011 Jan;23(1):239-48. doi: 10.1016/j.cellsig.2010.09.008. Epub 2010 Sep 16.

5.

Activation of the Akt-mTOR pathway and receptor tyrosine kinase in patients with solitary fibrous tumors.

Yamada Y, Kohashi K, Fushimi F, Takahashi Y, Setsu N, Endo M, Yamamoto H, Tokunaga S, Iwamoto Y, Oda Y.

Cancer. 2014 Mar 15;120(6):864-76. doi: 10.1002/cncr.28506. Epub 2013 Dec 18.

6.

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.

Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PP.

Curr Biol. 2008 Sep 9;18(17):1269-77. doi: 10.1016/j.cub.2008.07.078. Epub 2008 Aug 21.

7.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94. Epub 2004 Sep 1.

8.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

9.

Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase.

Arvisais E, Hou X, Wyatt TA, Shirasuna K, Bollwein H, Miyamoto A, Hansen TR, Rueda BR, Davis JS.

Mol Endocrinol. 2010 Mar;24(3):632-43. doi: 10.1210/me.2009-0312. Epub 2010 Feb 16.

10.
11.

Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.

Khan N, Afaq F, Khusro FH, Mustafa Adhami V, Suh Y, Mukhtar H.

Int J Cancer. 2012 Apr 1;130(7):1695-705. doi: 10.1002/ijc.26178. Epub 2011 Aug 26.

12.

Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.

Kendall RT, Lee MH, Pleasant DL, Robinson K, Kuppuswamy D, McDermott PJ, Luttrell LM.

J Biol Chem. 2014 Sep 19;289(38):26155-66. doi: 10.1074/jbc.M114.595728. Epub 2014 Jul 31.

13.

Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner.

Roffé M, Lupinacci FC, Soares LC, Hajj GN, Martins VR.

Cell Signal. 2015 Aug;27(8):1630-42. doi: 10.1016/j.cellsig.2015.04.004. Epub 2015 Apr 16.

PMID:
25889895
14.

Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation.

Ghosh PM, Malik SN, Bedolla RG, Wang Y, Mikhailova M, Prihoda TJ, Troyer DA, Kreisberg JI.

Endocr Relat Cancer. 2005 Mar;12(1):119-34.

15.

Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.

Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A.

J Biol Chem. 2009 Feb 13;284(7):4052-61. doi: 10.1074/jbc.M805032200. Epub 2008 Dec 13.

16.

Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb) in human breast carcinoma cells.

Vazquez-Martin A, Oliveras-Ferraros C, Colomer R, Brunet J, Menendez JA.

Ann Oncol. 2008 Jun;19(6):1097-109. doi: 10.1093/annonc/mdm589. Epub 2008 Feb 17.

PMID:
18283037
18.

Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy.

Surviladze Z, Sterk RT, DeHaro SA, Ozbun MA.

J Virol. 2013 Mar;87(5):2508-17. doi: 10.1128/JVI.02319-12. Epub 2012 Dec 19.

19.

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.

Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP.

Biochem J. 2008 May 1;411(3):647-55. doi: 10.1042/BJ20071084.

20.

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.

Stratford AL, Fry CJ, Desilets C, Davies AH, Cho YY, Li Y, Dong Z, Berquin IM, Roux PP, Dunn SE.

Breast Cancer Res. 2008;10(6):R99. doi: 10.1186/bcr2202. Epub 2008 Nov 27.

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