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Items: 1 to 20 of 113


Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear.

Pan W, Jin Y, Stanger B, Kiernan AE.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15798-803. doi: 10.1073/pnas.1003089107. Epub 2010 Aug 23.


Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.

Pan W, Jin Y, Chen J, Rottier RJ, Steel KP, Kiernan AE.

J Neurosci. 2013 Oct 9;33(41):16146-57. doi: 10.1523/JNEUROSCI.3150-12.2013.


Overactivation of Notch1 signaling induces ectopic hair cells in the mouse inner ear in an age-dependent manner.

Liu Z, Owen T, Fang J, Zuo J.

PLoS One. 2012;7(3):e34123. doi: 10.1371/journal.pone.0034123. Epub 2012 Mar 20.


Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear.

Hartman BH, Reh TA, Bermingham-McDonogh O.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15792-7. doi: 10.1073/pnas.1002827107. Epub 2010 Aug 23.


Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear.

Brooker R, Hozumi K, Lewis J.

Development. 2006 Apr;133(7):1277-86. Epub 2006 Feb 22.


The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.

Kiernan AE, Xu J, Gridley T.

PLoS Genet. 2006 Jan;2(1):e4. Epub 2006 Jan 13.


Rbpj regulates development of prosensory cells in the mammalian inner ear.

Yamamoto N, Chang W, Kelley MW.

Dev Biol. 2011 May 15;353(2):367-79. doi: 10.1016/j.ydbio.2011.03.016. Epub 2011 Mar 21.


Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells.

Jeon SJ, Fujioka M, Kim SC, Edge AS.

J Neurosci. 2011 Jun 8;31(23):8351-8. doi: 10.1523/JNEUROSCI.6366-10.2011.


Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa.

Basch ML, Ohyama T, Segil N, Groves AK.

J Neurosci. 2011 Jun 1;31(22):8046-58. doi: 10.1523/JNEUROSCI.6671-10.2011.


Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.

Yamamoto N, Tanigaki K, Tsuji M, Yabe D, Ito J, Honjo T.

J Mol Med (Berl). 2006 Jan;84(1):37-45. Epub 2005 Nov 8.


The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.

Moayedi Y, Basch ML, Pacheco NL, Gao SS, Wang R, Harrison W, Xiao N, Oghalai JS, Overbeek PA, Mardon G, Groves AK.

PLoS Genet. 2014 Jan;10(1):e1004055. doi: 10.1371/journal.pgen.1004055. Epub 2014 Jan 2.


Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ.

Mech Dev. 1998 Nov;78(1-2):159-63.


The Notch ligand Jagged1 is required for inner ear sensory development.

Kiernan AE, Ahituv N, Fuchs H, Balling R, Avraham KB, Steel KP, Hrabé de Angelis M.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3873-8. Epub 2001 Mar 20.


Hes5 expression in the postnatal and adult mouse inner ear and the drug-damaged cochlea.

Hartman BH, Basak O, Nelson BR, Taylor V, Bermingham-McDonogh O, Reh TA.

J Assoc Res Otolaryngol. 2009 Sep;10(3):321-40. doi: 10.1007/s10162-009-0162-2. Epub 2009 Apr 17.


Notch signaling and the developing inner ear.

Murata J, Ikeda K, Okano H.

Adv Exp Med Biol. 2012;727:161-73. doi: 10.1007/978-1-4614-0899-4_12. Review.


In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium.

Tateya T, Sakamoto S, Imayoshi I, Kageyama R.

Hear Res. 2015 Sep;327:209-17. doi: 10.1016/j.heares.2015.07.012. Epub 2015 Jul 22.


Sensory organ development in the inner ear: molecular and cellular mechanisms.

Bryant J, Goodyear RJ, Richardson GP.

Br Med Bull. 2002;63:39-57. Review.


Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.

Savoy-Burke G, Gilels FA, Pan W, Pratt D, Que J, Gan L, White PM, Kiernan AE.

PLoS One. 2014 Sep 29;9(9):e108160. doi: 10.1371/journal.pone.0108160. eCollection 2014.

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