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Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols.

Cao P, Raleigh DP.

Biochemistry. 2012 Apr 3;51(13):2670-83. doi: 10.1021/bi2015162. Epub 2012 Mar 21.


Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers.

Noor H, Cao P, Raleigh DP.

Protein Sci. 2012 Mar;21(3):373-82. doi: 10.1002/pro.2023. Epub 2012 Jan 31.


Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions.

Tu LH, Young LM, Wong AG, Ashcroft AE, Radford SE, Raleigh DP.

Biochemistry. 2015 Jan 27;54(3):666-76. doi: 10.1021/bi501016r. Epub 2015 Jan 15.


The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation.

Meng F, Abedini A, Plesner A, Middleton CT, Potter KJ, Zanni MT, Verchere CB, Raleigh DP.

J Mol Biol. 2010 Jul 16;400(3):555-66. doi: 10.1016/j.jmb.2010.05.001. Epub 2010 May 7.


Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death.

Meng F, Marek P, Potter KJ, Verchere CB, Raleigh DP.

Biochemistry. 2008 Jun 3;47(22):6016-24. doi: 10.1021/bi702518m. Epub 2008 May 6.


Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide.

Yan LM, Velkova A, Kapurniotu A.

Curr Pharm Des. 2014;20(8):1182-91.


Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.

Jaikaran ET, Clark A.

Biochim Biophys Acta. 2001 Nov 29;1537(3):179-203. Review.


General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers.

Wang H, Raleigh DP.

PLoS One. 2014 Sep 26;9(9):e104023. doi: 10.1371/journal.pone.0104023. eCollection 2014.


Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin.

Yagui K, Yamaguchi T, Kanatsuka A, Shimada F, Huang CI, Tokuyama Y, Ohsawa H, Yamamura K, Miyazaki J, Mikata A, et al.

Eur J Endocrinol. 1995 Apr;132(4):487-96.


Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.


In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease.

Oskarsson ME, Paulsson JF, Schultz SW, Ingelsson M, Westermark P, Westermark GT.

Am J Pathol. 2015 Mar;185(3):834-46. doi: 10.1016/j.ajpath.2014.11.016. Epub 2015 Feb 17.


Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation.

Sjölander J, Westermark GT, Renström E, Blom AM.

J Biol Chem. 2012 Mar 30;287(14):10824-33. doi: 10.1074/jbc.M111.244285. Epub 2012 Feb 13.


Fluorescence microscopy studies on islet amyloid polypeptide fibrillation at heterogeneous and cellular membrane interfaces and its inhibition by resveratrol.

Radovan D, Opitz N, Winter R.

FEBS Lett. 2009 May 6;583(9):1439-45. doi: 10.1016/j.febslet.2009.03.059. Epub 2009 Apr 2.


Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

Westermark P, Engström U, Johnson KH, Westermark GT, Betsholtz C.

Proc Natl Acad Sci U S A. 1990 Jul;87(13):5036-40.


Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus.

Jeong HR, An SS.

Clin Interv Aging. 2015 Nov 19;10:1873-9. doi: 10.2147/CIA.S95297. eCollection 2015. Review.


Human islet amyloid polypeptide fibril binding to catalase: a transmission electron microscopy and microplate study.

Milton NG, Harris JR.

ScientificWorldJournal. 2010 May 18;10:879-93. doi: 10.1100/tsw.2010.73.


Enhanced in vitro production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide.

Ma Z, Westermark GT, Sakagashira S, Sanke T, Gustavsson A, Sakamoto H, Engström U, Nanjo K, Westermark P.

Amyloid. 2001 Dec;8(4):242-9.


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