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Intestinal goblet cells and mucins in health and disease: recent insights and progress.

Kim YS, Ho SB.

Curr Gastroenterol Rep. 2010 Oct;12(5):319-30. doi: 10.1007/s11894-010-0131-2. Review.


γδ T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer.

Kober OI, Ahl D, Pin C, Holm L, Carding SR, Juge N.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G582-93. doi: 10.1152/ajpgi.00218.2013. Epub 2014 Feb 6.


The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.

Pelaseyed T, Bergström JH, Gustafsson JK, Ermund A, Birchenough GM, Schütte A, van der Post S, Svensson F, Rodríguez-Piñeiro AM, Nyström EE, Wising C, Johansson ME, Hansson GC.

Immunol Rev. 2014 Jul;260(1):8-20. doi: 10.1111/imr.12182. Review.


Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin TH, Goodnow CC, McGuckin MA.

PLoS Med. 2008 Mar 4;5(3):e54. doi: 10.1371/journal.pmed.0050054.


Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice.

Krimi RB, Kotelevets L, Dubuquoy L, Plaisancié P, Walker F, Lehy T, Desreumaux P, Van Seuningen I, Chastre E, Forgue-Lafitte ME, Marie JC.

Inflamm Bowel Dis. 2008 Jul;14(7):931-41. doi: 10.1002/ibd.20420.


The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions.

Johansson ME, Larsson JM, Hansson GC.

Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4659-65. doi: 10.1073/pnas.1006451107. Epub 2010 Jun 25.


Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins.

Johansson ME.

PLoS One. 2012;7(7):e41009. doi: 10.1371/journal.pone.0041009. Epub 2012 Jul 17.


Colonic expression of MUC2, MUC5AC, and TFF1 in inflammatory bowel disease in children.

Shaoul R, Okada Y, Cutz E, Marcon MA.

J Pediatr Gastroenterol Nutr. 2004 May;38(5):488-93.


Heterogeneity of mucin gene expression in normal and neoplastic tissues.

Ho SB, Niehans GA, Lyftogt C, Yan PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS.

Cancer Res. 1993 Feb 1;53(3):641-51.


The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.

Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9. doi: 10.1073/pnas.0803124105. Epub 2008 Sep 19.


Specific secretion of gel-forming mucins and TFF peptides in HT-29 cells of mucin-secreting phenotype.

Gouyer V, Wiede A, Buisine MP, Dekeyser S, Moreau O, Lesuffleur T, Hoffmann W, Huet G.

Biochim Biophys Acta. 2001 May 28;1539(1-2):71-84.


Expression of MUC2 and MUC3 mRNA in human normal, malignant, and inflammatory intestinal tissues.

Weiss AA, Babyatsky MW, Ogata S, Chen A, Itzkowitz SH.

J Histochem Cytochem. 1996 Oct;44(10):1161-6.


The rat IgGFcγBP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction.

Yu H, He Y, Zhang X, Peng Z, Yang Y, Zhu R, Bai J, Tian Y, Li X, Chen W, Fang D, Wang R.

PLoS One. 2011;6(5):e20334. doi: 10.1371/journal.pone.0020334. Epub 2011 May 23.


Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.

Johansson ME, Thomsson KA, Hansson GC.

J Proteome Res. 2009 Jul;8(7):3549-57. doi: 10.1021/pr9002504.


Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis.

McElroy SJ, Prince LS, Weitkamp JH, Reese J, Slaughter JC, Polk DB.

Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G656-66. doi: 10.1152/ajpgi.00550.2010. Epub 2011 Jul 7.


Microbial modulation of innate defense: goblet cells and the intestinal mucus layer.

Deplancke B, Gaskins HR.

Am J Clin Nutr. 2001 Jun;73(6):1131S-1141S. Review.


Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA.

PLoS Pathog. 2010 May 13;6(5):e1000902. doi: 10.1371/journal.ppat.1000902.


Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6.

Durual S, Blanchard C, Estienne M, Jacquier MF, Cuber JC, Perrot V, Laboisse C, Cuber JC.

Differentiation. 2005 Feb;73(1):36-44.


Gastrointestinal expression and partial cDNA cloning of murine Muc2.

van Klinken BJ, Einerhand AW, Duits LA, Makkink MK, Tytgat KM, Renes IB, Verburg M, Büller HA, Dekker J.

Am J Physiol. 1999 Jan;276(1 Pt 1):G115-24.

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