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Items: 1 to 20 of 113

1.

Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling.

Müller M, Cheung KH, Foskett JK.

Antioxid Redox Signal. 2011 Apr 1;14(7):1225-35. doi: 10.1089/ars.2010.3421.

2.

Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.

Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK.

Sci Signal. 2010 Mar 23;3(114):ra22. doi: 10.1126/scisignal.2000818.

3.

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.

Müller M, Cárdenas C, Mei L, Cheung KH, Foskett JK.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13293-8. doi: 10.1073/pnas.1109297108.

4.

Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK.

Neuron. 2008 Jun 26;58(6):871-83. doi: 10.1016/j.neuron.2008.04.015.

5.

Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.

Shilling D, Müller M, Takano H, Mak DO, Abel T, Coulter DA, Foskett JK.

J Neurosci. 2014 May 14;34(20):6910-23. doi: 10.1523/JNEUROSCI.5441-13.2014.

6.

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.

Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I.

Cell. 2006 Sep 8;126(5):981-93.

7.

Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.

Shilling D, Mak DO, Kang DE, Foskett JK.

J Biol Chem. 2012 Mar 30;287(14):10933-44. doi: 10.1074/jbc.M111.300491.

8.

Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.

Rivabene R, Visentin S, Piscopo P, De Nuccio C, Crestini A, Svetoni F, Rosa P, Confaloni A.

Exp Biol Med (Maywood). 2014 Feb;239(2):213-24. doi: 10.1177/1535370213514317.

PMID:
24363250
9.

Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.

Ryazantseva M, Skobeleva K, Glushankova L, Kaznacheyeva E.

J Neurochem. 2016 Mar;136(5):1085-95. doi: 10.1111/jnc.13495.

PMID:
26678016
10.

Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins.

Mak DO, Cheung KH, Toglia P, Foskett JK, Ullah G.

PLoS Comput Biol. 2015 Oct 6;11(10):e1004529. doi: 10.1371/journal.pcbi.1004529.

11.

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.

Cell Calcium. 2006 Jun;39(6):539-50.

PMID:
16620965
12.

Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease.

Bojarski L, Pomorski P, Szybinska A, Drab M, Skibinska-Kijek A, Gruszczynska-Biegala J, Kuznicki J.

Biochim Biophys Acta. 2009 Jun;1793(6):1050-7. doi: 10.1016/j.bbamcr.2008.11.008.

13.

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Fukumori A, Fluhrer R, Steiner H, Haass C.

J Neurosci. 2010 Jun 9;30(23):7853-62. doi: 10.1523/JNEUROSCI.1443-10.2010.

14.

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.

J Clin Invest. 2007 May;117(5):1230-9.

15.

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.

Neurobiol Dis. 2007 Jul;27(1):102-7.

PMID:
17560791
16.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
18.
19.

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.

Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM.

J Cell Biol. 2008 Jun 30;181(7):1107-16. doi: 10.1083/jcb.200706171.

20.

The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.

Lessard CB, Lussier MP, Cayouette S, Bourque G, Boulay G.

Cell Signal. 2005 Apr;17(4):437-45.

PMID:
15601622
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