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Items: 1 to 20 of 147

1.

The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome.

Seo H, Isacson O.

J Neurochem. 2010 Sep;114(6):1819-26. doi: 10.1111/j.1471-4159.2010.06902.x. Epub 2010 Aug 3.

2.
3.

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.

Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L.

J Biol Chem. 1995 Nov 24;270(47):28257-67.

4.

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC.

Neuron. 2006 Jul 6;51(1):29-42.

5.

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.

Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E.

J Biol Chem. 2005 Sep 23;280(38):32957-67. Epub 2005 Jul 15.

6.

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D.

J Neurosci. 1996 Sep 15;16(18):5795-811.

7.

Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease.

Botella-López A, Cuchillo-Ibáñez I, Cotrufo T, Mok SS, Li QX, Barquero MS, Dierssen M, Soriano E, Sáez-Valero J.

Neurobiol Dis. 2010 Mar;37(3):682-91. doi: 10.1016/j.nbd.2009.12.006. Epub 2009 Dec 16.

PMID:
20025970
8.

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling.

Rossner S, Ueberham U, Schliebs R, Perez-Polo JR, Bigl V.

Prog Neurobiol. 1998 Dec;56(5):541-69. Review.

PMID:
9775403
9.

Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.

Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L.

J Neurosci. 2007 Mar 14;27(11):2727-33.

10.

Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease.

Van Ess PJ, Pedersen WA, Culmsee C, Mattson MP, Blouin RA.

J Neurochem. 2002 Feb;80(4):571-8.

11.

Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease.

Sberna G, Sáez-Valero J, Li QX, Czech C, Beyreuther K, Masters CL, McLean CA, Small DH.

J Neurochem. 1998 Aug;71(2):723-31.

12.

Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein.

Santosa C, Rasche S, Barakat A, Bellingham SA, Ho M, Tan J, Hill AF, Masters CL, McLean C, Evin G.

Neurobiol Dis. 2011 Jul;43(1):176-83. doi: 10.1016/j.nbd.2011.03.009. Epub 2011 Apr 3.

PMID:
21440067
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14.

Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome.

Beyreuther K, Pollwein P, Multhaup G, Mönning U, König G, Dyrks T, Schubert W, Masters CL.

Ann N Y Acad Sci. 1993 Sep 24;695:91-102. Review.

PMID:
8239320
15.

Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.

Murai H, Pierce JE, Raghupathi R, Smith DH, Saatman KE, Trojanowski JQ, Lee VM, Loring JF, Eckman C, Younkin S, McIntosh TK.

J Comp Neurol. 1998 Mar 23;392(4):428-38.

PMID:
9514508
16.

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease.

Ryoo SR, Cho HJ, Lee HW, Jeong HK, Radnaabazar C, Kim YS, Kim MJ, Son MY, Seo H, Chung SH, Song WJ.

J Neurochem. 2008 Mar;104(5):1333-44. Epub 2007 Nov 14.

17.

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L.

J Neurosci. 2000 Jun 1;20(11):4050-8.

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19.

Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice.

Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR.

Brain Res. 1994 Dec 15;666(2):151-67.

PMID:
7882025
20.

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