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Items: 1 to 20 of 122

1.

4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway.

Zhang Y, Sano M, Shinmura K, Tamaki K, Katsumata Y, Matsuhashi T, Morizane S, Ito H, Hishiki T, Endo J, Zhou H, Yuasa S, Kaneda R, Suematsu M, Fukuda K.

J Mol Cell Cardiol. 2010 Oct;49(4):576-86. doi: 10.1016/j.yjmcc.2010.05.011. Epub 2010 Jun 4.

PMID:
20685357
2.

4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes.

López-Bernardo E, Anedda A, Sánchez-Pérez P, Acosta-Iborra B, Cadenas S.

Free Radic Biol Med. 2015 Nov;88(Pt B):427-438. doi: 10.1016/j.freeradbiomed.2015.03.032. Epub 2015 Apr 3.

PMID:
25843654
3.

Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE.

Chen J, Wang L, Chen Y, Sternberg P, Cai J.

Invest Ophthalmol Vis Sci. 2009 Feb;50(2):936-42. doi: 10.1167/iovs.08-2439. Epub 2008 Sep 20.

5.

Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.

He L, Liu B, Dai Z, Zhang HF, Zhang YS, Luo XJ, Ma QL, Peng J.

Eur J Pharmacol. 2012 Mar 5;678(1-3):32-8. doi: 10.1016/j.ejphar.2011.12.042. Epub 2012 Jan 12.

PMID:
22266491
6.

Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress.

Zhu H, Jia Z, Misra BR, Zhang L, Cao Z, Yamamoto M, Trush MA, Misra HP, Li Y.

Cardiovasc Toxicol. 2008 Summer;8(2):71-85. doi: 10.1007/s12012-008-9016-0. Epub 2008 May 8.

PMID:
18463988
7.

4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2.

Chen ZH, Saito Y, Yoshida Y, Sekine A, Noguchi N, Niki E.

J Biol Chem. 2005 Dec 23;280(51):41921-7. Epub 2005 Oct 11.

8.

Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2.

Katsumata Y, Shinmura K, Sugiura Y, Tohyama S, Matsuhashi T, Ito H, Yan X, Ito K, Yuasa S, Ieda M, Urade Y, Suematsu M, Fukuda K, Sano M.

Hypertension. 2014 Jan;63(1):80-7. doi: 10.1161/HYPERTENSIONAHA.113.01639. Epub 2013 Oct 7.

9.

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.

Sha LK, Sha W, Kuchler L, Daiber A, Giegerich AK, Weigert A, Knape T, Snodgrass R, Schröder K, Brandes RP, Brüne B, von Knethen A.

Free Radic Biol Med. 2015 Jun;83:77-88. doi: 10.1016/j.freeradbiomed.2015.02.004. Epub 2015 Feb 14.

PMID:
25687825
10.

Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells.

Wu PS, Yen JH, Kou MC, Wu MJ.

PLoS One. 2015 Jun 18;10(6):e0130599. doi: 10.1371/journal.pone.0130599. eCollection 2015.

11.

Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes.

Tsai CY, Wang CC, Lai TY, Tsu HN, Wang CH, Liang HY, Kuo WW.

Int J Cardiol. 2013 Sep 30;168(2):1286-97. doi: 10.1016/j.ijcard.2012.12.004. Epub 2013 Feb 27.

PMID:
23453443
12.

Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal.

Gatbonton-Schwager TN, Sadhukhan S, Zhang GF, Letterio JJ, Tochtrop GP.

Redox Biol. 2014 Apr 24;2:755-63. doi: 10.1016/j.redox.2014.04.009. eCollection 2014.

13.

Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro.

Tanito M, Agbaga MP, Anderson RE.

Free Radic Biol Med. 2007 Jun 15;42(12):1838-50. Epub 2007 Mar 24.

PMID:
17512463
14.

Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro.

Peng B, Zhao P, Lu YP, Chen MM, Sun H, Wu XM, Zhu L.

Brain Res. 2013 Jul 3;1520:168-77. doi: 10.1016/j.brainres.2013.05.009. Epub 2013 May 18.

PMID:
23688544
15.

Nrf2 activation protects the liver from ischemia/reperfusion injury in mice.

Kudoh K, Uchinami H, Yoshioka M, Seki E, Yamamoto Y.

Ann Surg. 2014 Jul;260(1):118-27. doi: 10.1097/SLA.0000000000000287.

16.

Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.

Ueda K, Ueyama T, Yoshida K, Kimura H, Ito T, Shimizu Y, Oka M, Tsuruo Y, Ichinose M.

Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G460-9. doi: 10.1152/ajpgi.00204.2007. Epub 2008 Jul 10.

PMID:
18617559
17.

Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling.

Gao S, Yang Z, Shi R, Xu D, Li H, Xia Z, Wu QP, Yao S, Wang T, Yuan S.

Eur J Pharmacol. 2016 May 15;779:111-21. doi: 10.1016/j.ejphar.2016.03.018. Epub 2016 Mar 10.

PMID:
26973173
18.

Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ.

J Neurochem. 2015 Apr;133(2):233-41. doi: 10.1111/jnc.13064. Epub 2015 Mar 4.

19.
20.

Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo.

Miller DM, Singh IN, Wang JA, Hall ED.

Free Radic Biol Med. 2013 Apr;57:1-9. doi: 10.1016/j.freeradbiomed.2012.12.011. Epub 2012 Dec 27.

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